Chemokine networks in atopic dermatitis: Traffic signals of disease

Current Allergy and Asthma Reports

Volumn 5, Issue 4, 2005, Pages 284-290

  Pivarcsi, Andor ^a   Homey, Bernhard ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE CCL18; CHEMOKINE CCL22; CHEMOKINE CCL27; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; EOTAXIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 4; THYMUS AND ACTIVATION REGULATED CHEMOKINE; UNCLASSIFIED DRUG;

ANTIGEN PRESENTING CELL; ATOPIC DERMATITIS; CELL MATURATION; CELL POPULATION; DENDRITIC CELL; DISEASE ACTIVITY; DNA MICROARRAY; EOSINOPHIL; GENE EXPRESSION; GENETIC SCREENING; HUMAN; IMMUNOPATHOGENESIS; KERATINOCYTE; LEUKOCYTE MIGRATION; LYMPHOCYTE HOMING; MOLECULAR MECHANICS; NONHUMAN; PHENOTYPE; RECEPTOR BINDING; REVIEW; TH2 CELL;

EID: 23844488693     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-005-0068-y     Document Type: Review

References (59)

1. Leung DY, Bieber T: Atopic dermatitis. Lancet 2003, 361:151-160.
2. Grewe M, Bruijnzeel-Koomen CA, Schopf E, et al.: A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 1998, 19:359-361.
3. Picker LJ, Terstappen LW, Rott LS, et al.: Differential expression of homing-associated adhesion molecules by T cell subsets in man. J Immunol 1990, 145:3247-3255.
4. Picker LJ, Treer JR, Ferguson-Darnell B, et al.: Control of lymphocyte recirculation in man. II. Differential regulation of the cutaneous lymphocyte-associated antigen, a tissue-selective homing receptor for skin-homing T cells. J Immunol 1993, 150:1122-1136.
5. Santamaria LF, Perez Soler MT, Hauser C, Blaser K: Allergen specificity and endothelial transmigration of T cells in allergic contact dermatitis and atopic dermatitis are associated with the cutaneous lymphocyte antigen. Int Arch Allergy Immunol 1995, 107:359-362.
6. Santamaria Babi LF, Picker LJ, Perez Soler MT, et al.: Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen. J Exp Med 1995, 181:1935-1940.
7. Berg EL, Yoshino T, Rott LS, et al.: The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 1991, 174:1461-1466.
8. Homey B: Chemokines and chemokine receptors as targets in the therapy of psoriasis. Curr Drug Targets Inflamm Allergy 2004, 3:169-174.
9. Matsukawa A, Hogaboam CM, Lukacs NW, Kunkel SL: Chemokines and innate immunity. Rev Immunogenet 2000, 2:339-358.
10. Homey B, Zlotnik A: Chemokines in allergy. Curr Opin Immunol 1999, 11:626-634.
11. Zlotnik A, Yoshie O: Chemokines: a new classification system and their role in immunity. Immunity 2000, 12:121-127.
12. Laitinen T, Polvi A, Rydman P, et al.: Characterization of a common susceptibility locus for asthma-related traits. Science 2004, 304:300-304.
13. Homey B, Bunemann E: Chemokines and inflammatory skin diseases. Ernst Schering Res Found Workshop 2004, 45:69-83.
14. Tan J, Thestrup-Pedersen K: T lymphocyte chemotaxis and skin diseases. Exp Dermatol 1995, 4:281-290.
15. Homey B, Wang W, Soto H, et al.: Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol 2000, 164:3465-3470.
16. Morales J, Homey B, Vicari AP, et al.: CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc Natl Acad Sci U S A 1999, 96:14470-14475.
17. Homey B, Alenius H, Muller A, et al.: CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 2002, 8:157-165.
18. Kakinuma T, Saeki H, Tsunemi Y, et al.: Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. J Allergy Clin Immunol 2003, 111:592-597.
19. Hon KL, Leung TF, Ma KC, et al.: Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. Clin Exp Dermatol 2004, 29:293-296.
20. Hijnen D, De Bruin-Weller M, Oosting B, et al.: Serum thymus and activation-regulated chemokine (TARC) and cutaneous T cell- attracting chemokine (CTACK) levels in allergic diseases: TARC and CTACK are disease-specific markers for atopic dermatitis. J Allergy Clin Immunol 2004, 113:334-340.
21. Baekkevold ES, Yamanaka T, Palframan RT, et al.: The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med 2001, 193:1105-1112.
22. Middleton J, Neil S, Wintle J, et al.: Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 1997, 91:385-395.
23. Tapia B, Padial A, Sanchez-Sabate E, et al.: Involvement of CCL27-CCR10 interactions in drug-induced cutaneous reactions. J Allergy Clin Immunol 2004, 114:335-340.
24. Imai T, Baba M, Nishimura M, et al.: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J Biol Chem 1997, 272:15036-15042.
25. Campbell JJ, Haraldsen G, Pan J, et al.: The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999, 400:776-780.
26. Biedermann T, Schwarzler C, Lametschwandtner G, et al.: Targeting CLA/E-selectin interactions prevents CCR4-mediated recruitment of human Th2 memory cells to human skin in vivo. Eur J Immunol 2002, 32:3171-3180.
27. Zheng X, Nakamura K, Furukawa H, et al.: Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis. J Dermatol 2003, 30:26-32.
28. Vestergaard C, Bang K, Gesser B, et al.: A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin. J Invest Dermatol 2000, 115:640-646.
29. Vulcano M, Albanesi C, Stoppacciaro A, et al.: Dendritic cells as a major source of macrophage-derived chemokine /CCL22 in vitro and in vivo. Eur J Immunol 2001, 31:812-822.
30. Katou F, Ohtani H, Nakayama T, et al.: Macrophage-derived chemokine (MDC/CCL22) and CCR4 are involved in the formation of T lymphocyte-dendritic cell clusters in human inflamed skin and secondary lymphoid tissue. Am J Pathol 2001, 158:1263-1270.
31. Bonecchi R, Bianchi G, Bordignon PP, et al.: Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998, 187:129-134.
32. Imai T, Nagira M, Takagi S, et al.: Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol 1999, 11:81-88.
33. Kakinuma T, Nakamura K, Wakugawa M, et al.: Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity. J Allergy Clin Immunol 2001, 107:535-541.
34. Kakinuma T, Nakamura K, Wakugawa M, et al.: Serum macrophage-derived chemokine (MDC) levels are closely related with the disease activity of atopic dermatitis. Clin Exp Immunol 2002, 127:270-273.
35. Reiss Y, Proudfoot AE, Power CA, et al.: CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med 2001, 194:1541-1547.
36. Campbell JJ, Butcher EC: Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000, 12:336-341.
37. Pivarcsi A, Gombert M, Dieu-Nosjean MC, et al.: CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure. J Immunol 2004, 173:5810-5817.
38. Nomura I, Gao B, Boguniewicz M, et al.: Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J Allergy Clin Immunol 2003, 112:1195-1202.
39. Zou J, Young S, Zhu F, et al.: Microarray profile of differentially expressed genes in a monkey model of allergic asthma. Genome Biol 2002, 3:11.
40. Gunther C, Bello-Fernandez C, Kopp T, et al.: CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells. J Immunol 2005, 174:1723-1728.
41. Bruna-Romero O, Schmieg J, Del Val M, et al.: The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria. J Immunol 2003, 170:3195-3203.
42. Banfield CC, Callard RE, Harper JI: The role of cutaneous dendritic cells in the immunopathogenesis of atopic dermatitis. Br J Dermatol 2001, 144:940-946.
43. Vanbervliet B, Homey B, Durand I, et al.: Sequential involvement of CCR2 and CCR6 ligands for immature dendritic cell recruitment: possible role at inflamed epithelial surfaces. Eur J Immunol 2002, 32:231-242.
44. Dieu-Nosjean MC, Massacrier C, Homey B, et al.: Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med 2000, 192:705-718.
45. Nakayama T, Fujisawa R, Yamada H, et al.: Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3 alpha/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol 2001, 13:95-103.
46. Caux C, Ait-Yahia S, Chemin K, et al.: Dendritic cell biology and regulation of dendritic cell trafficking by chemokines. Springer Semin Immunopathol 2000, 22:345-369.
47. Taha RA, Minshall EM, Leung DY, et al.: Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis. J Allergy Clin Immunol 2000, 105:1002-1007.
48. Yawalkar N, Uguccioni M, Scharer J, et al.: Enhanced expression of eotaxin and CCR3 in atopic dermatitis. J Invest Dermatol 1999, 113:43-48.
49. Ying S, Robinson DS, Meng Q, et al.: C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and relationship to basophils and other C-C chemokines (monocyte chemoattractant protein-3 and RANTES). J Immunol 1999, 163:3976-3984.
50. Kagami S, Kakinuma T, Saeki H, Y et al.: Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis. Clin Exp Immunol 2003, 134:309-313.
51. Ma W, Bryce PJ, Humbles AA, et al.: CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest 2002, 109:621-628.
52. Elsner J, Escher SE, Forssmann U: Chemokine receptor antagonists: a novel therapeutic approach in allergic diseases. Allergy 2004, 59:1243-1258.
53. Kawasaki S, Takizawa H, Yoneyama H, et al.: Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice. J Immunol 2001, 166:2055-2062.
54. Chvatchko Y, Hoogewerf AJ, Meyer A, et al.: A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med 2000, 191:1755-1764.
55. Gonzalo JA, Lloyd CM, Wen D, et al.: The coordinated action of CC chemokines in the lung orchestrates allergic inflammation and airway hyperresponsiveness. J Exp Med 1998, 188:157-167.
56. Luster AD: Antichemokine immunotherapy for allergic diseases. Curr Opin Allergy Clin Immunol 2001, 1:561-567.
57. Kaburagi Y, Shimada Y, Nagaoka T, et al.: Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1alpha, MIP-1beta, and eotaxin) in patients with atopic dermatitis. Arch Dermatol Res 2001, 293:350-355.
58. Ying S, Taborda-Barata L, Meng Q, et al.: The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T cell, and macrophage recruitment. J Exp Med 1995, 181:2153-2159.
59. Fraticelli P, Sironi M, Bianchi G, et al.: Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses. J Clin Invest 2001, 107:1173-1181.