Designing and testing of novel taxanes to probe the highly complex mechanisms by which taxanes bind to microtubules and cause cytotoxicity to cancer cells

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  St George, Marc ^a   Ayoub, Ahmed T ^a   Banerjee, Asok ^b   Churchill, Cassandra D M ^a   Winter, Philip ^a   Klobukowski, Mariusz ^a   Cass, Carol E ^a   Ludueña, Richard F ^b   Tuszynski, Jack A ^a   Damaraju, Sambasivarao ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; DOCETAXEL; GLYCOPROTEIN; PACLITAXEL; TAXANE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; TAXOID; TUBULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; BREAST CANCER CELL LINE; CANCER CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; IC50; IN VITRO STUDY; MDA MB 231 CANCER CELL LINE; MICROTUBULE; MOLECULAR DYNAMICS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SK BR 3 CANCER CELL LINE; T 47D CANCER CELL LINE; TUBULIN POLYMERIZATION ASSAY; CELL DEATH; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR DOCKING; PERMEABILITY; POLYMERIZATION; THERMODYNAMICS; TUMOR CELL LINE; WESTERN BLOTTING;

BINDING SITES; BLOTTING, WESTERN; CELL DEATH; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICROTUBULES; MOLECULAR DOCKING SIMULATION; P-GLYCOPROTEIN; PACLITAXEL; PERMEABILITY; POLYMERIZATION; TAXOIDS; THERMODYNAMICS; TUBULIN;

EID: 84936851925     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0129168     Document Type: Article

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