Dual Allosteric Inhibitors Jointly Modulate Protein Structure and Dynamics in the Hepatitis C Virus Polymerase

Biochemistry

Volumn 54, Issue 26, 2015, Pages 4131-4141

  Brown, Jodian A ^a   Thorpe, Ian F ^a  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; BINS; ENZYMES; FUNCTIONAL POLYMERS; MOLECULAR DYNAMICS; VIRUSES;

ALLOSTERIC INHIBITOR; ENZYME ACTIVE SITES; HEPATITIS C VIRUS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR MECHANISM; NONOVERLAPPING; PROTEIN STRUCTURES; SIMULTANEOUS BINDINGS;

ENZYME INHIBITION;

HYDROGEN; NONSTRUCTURAL PROTEIN 5B; NUCLEOSIDE; VIRUS ENZYME; VIRUS RNA; ANTIVIRUS AGENT; ENZYME INHIBITOR; NS-5 PROTEIN, HEPATITIS C VIRUS; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; GENOTYPE; HEPATITIS C VIRUS; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; RNA REPLICATION; VIRUS REPLICATION; VIRUS RESISTANCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HEPACIVIRUS; HEPATITIS C; HUMAN; METABOLISM; VIROLOGY;

HEPATITIS C VIRUS;

ALLOSTERIC REGULATION; ANTIVIRAL AGENTS; ENZYME INHIBITORS; HEPACIVIRUS; HEPATITIS C; HUMANS; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; RNA REPLICASE; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84936818612     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b00411     Document Type: Article

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