Agonism/antagonism switching in allosteric ensembles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 11, 2012, Pages 4134-4139

  Motlagh, Hesam N ^a   Hilser, Vincent J ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Allostery; Conformational fluctuations; Ensemble; Population shift

Indexed keywords

AGONISM ANTAGONISM SWTICHING; ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; LIGAND BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS;

ALLOSTERIC REGULATION; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; PROTEINS; THERMODYNAMICS;

EID: 84858234186     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120519109     Document Type: Article

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