Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5217-5227

  Ontoria, Jesus M ^a   Rydberg, Edwin H ^a   Di Marco, Stefania ^a   Tomei, Licia ^a   Attenni, Barbara ^a   Malancona, Savina ^a   Martin Hernando, José I ^a   Gennari, Nadia ^a   Koch, Uwe ^a   Narjes, Frank ^a   Rowley, Michael ^a   Summa, Vincenzo ^a   Carroll, Steve S ^b   Olsen, David B ^b   De Francesco, Raffaele ^a   Altamura, Sergio ^a   Migliaccio, Giovanni ^a   Carfì, Andrea ^a  

^a IRBM   (Italy)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 4 [[2 (3 BROMOPHENYL) 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL]AMINO]PIPERIDINIUM TRIFLUOROACETATE; 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE DERIVATIVE; 2 (3 BROMOPHENYL) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 (CYCLOHEXYLAMINO) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 (ETHYLAMINO) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 [(2 HYDROXYETHYL)(METHYL)AMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 [(2 HYDROXYETHYL)AMINO] 1H BENZ[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 [(2 METHOXYETHYL)AMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 [(2 METHYLPROPYL)AMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 6 [[2 (METHYLAMINO)ETHYL]AMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 BROMOPHENYL) 7 [(2 HYDROXYETHYL)AMINO] 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 1 ONE; 2 (3 CHLOROPHENYL) 6 [(2 HYDROXYETHYL)AMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 (3 FLUOROPHENYL) 6 [(2 HYDROXYETHYL)AMINO] 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 2 [[2 (3 BROMOPHENYL) 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL]AMINO]ETHANOL; 3 [6 [(2 HYDROXYETHYL)AMINO] 1,3 DIOXO 1H BENZO[DE]ISOQUINOLIN 2(3H) YL]BENZENESULFONAMIDE; 4 [[2 (3 BROMOPHENYL) 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL]AMINO]CYCLOHEXANECARBOXYLIC ACID; 4 [[2 (3 BROMOPHENYL) 1,3 DIOXO 2,3 DIHYDRO 1H BENZO[DE]ISOQUINOLIN 6 YL]AMINO]PIPERIDINIUM TRIFLUOROACETATE; 6 [(2 HYDROXYETHYL)AMINO] 2 PHENYL 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; 6 AMINO 2 (3 BROMOPHENYL) 1H BENZO[DE]ISOQUINOLINE 1,3(2H) DIONE; ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 5B; RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DISTRIBUTION VOLUME; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME INHIBITION; HEPATITIS C VIRUS; IC 50; NONHUMAN; PROTEIN FUNCTION; RAT; REPLICON; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS REPLICATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; BINDING SITES; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, VIRAL; GENOTYPE; HEPACIVIRUS; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; RATS; REPLICON; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 69049091942     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900517t     Document Type: Article

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