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Volumn 13, Issue 3, 2009, Pages 453-465

HCV NS5B Polymerase Inhibitors

Author keywords

Antiviral therapy; Clinical trials; Hepatitis C; Non nucleoside analog; Nucleoside analog; Polymerase inhibitors

Indexed keywords

4' AZIDOCYTIDINE; 4' AZIDOCYTIDINE 2',3',5' TRIISOBUTYRATE; 5 CYCLOPROPYL 2 (4 FLUOROPHENYL) 6 [N (2 HYDROXYETHYL)METHANESULFONAMIDO] N METHYLBENZOFURAN 3 CARBOXAMIDE; ABT 333; ANA 598; ANTIVIRUS AGENT; BILB 1941; ENZYME INHIBITOR; GS 9190; GSK 625433; IDX 184; MK 0608; NM 107; NM 203; NONSTRUCTURAL PROTEIN 5B; NUCLEOSIDE DERIVATIVE; PEGINTERFERON; PF 868554; PLACEBO; PS 6130; R 1470; R 1728; R 7128; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RIBAVIRIN; UNCLASSIFIED DRUG; VALOPICITABINE; VCH 759; VCH 916;

EID: 67650631316     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2009.05.001     Document Type: Review
Times cited : (60)

References (41)
  • 1
    • 0036829649 scopus 로고    scopus 로고
    • National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C: 2002-June 10-12, 2002
    • National Institutes of Health Consensus Development Conference Statement: Management of hepatitis C: 2002-June 10-12, 2002. Hepatology 36 5 Suppl 1 (2002) S3-20
    • (2002) Hepatology , vol.36 , Issue.5 SUPPL. 1
  • 2
    • 0035934568 scopus 로고    scopus 로고
    • Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial
    • Mann M.P., McHutchison J.G., Cordon S.C., et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial. Lancet 358 (2001) 958-965
    • (2001) Lancet , vol.358 , pp. 958-965
    • Mann, M.P.1    McHutchison, J.G.2    Cordon, S.C.3
  • 3
    • 0037179698 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried M.W., Shiffman M.L., Reddy K.R., et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 347 (2002) 975-982
    • (2002) N Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, K.R.3
  • 4
    • 3343012408 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients
    • Torriani F.J., Rodriguez-Torres M., et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients. N Engl J Med 351 (2004) 438-450
    • (2004) N Engl J Med , vol.351 , pp. 438-450
    • Torriani, F.J.1    Rodriguez-Torres, M.2
  • 5
    • 3342892905 scopus 로고    scopus 로고
    • Peginterferon alfa-2a plus ribavirin versus interferon alfa 2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons
    • Chung T.R., Andersen J., Volberding P., et al. Peginterferon alfa-2a plus ribavirin versus interferon alfa 2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons. N Engl J Med 351 (2004) 451-459
    • (2004) N Engl J Med , vol.351 , pp. 451-459
    • Chung, T.R.1    Andersen, J.2    Volberding, P.3
  • 6
    • 33746535101 scopus 로고    scopus 로고
    • Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1
    • Conjeevaram H.S., Fried M.W., Jeffers L.J., et al. Peginterferon and ribavirin treatment in African American and Caucasian American patients with hepatitis C genotype 1. Gastroenterology 131 2 (2006) 470-477
    • (2006) Gastroenterology , vol.131 , Issue.2 , pp. 470-477
    • Conjeevaram, H.S.1    Fried, M.W.2    Jeffers, L.J.3
  • 7
    • 58849166746 scopus 로고    scopus 로고
    • Hepatitis C in the elderly; epidemiology, natural history and treatment
    • Mindikoglu A.L., and Miller R.R. Hepatitis C in the elderly; epidemiology, natural history and treatment. Clin Gastroenterol Hepatol 7 (2009) 128-134
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 128-134
    • Mindikoglu, A.L.1    Miller, R.R.2
  • 8
    • 3042621251 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C in patients with decompensated cirrhosis
    • Everson G.T. Treatment of chronic hepatitis C in patients with decompensated cirrhosis. Rev Gastroenterol Disord 4 Suppl 1 (2004) S31-S38
    • (2004) Rev Gastroenterol Disord , vol.4 , Issue.SUPPL. 1
    • Everson, G.T.1
  • 9
    • 36749001029 scopus 로고    scopus 로고
    • The way forward in HCV treatment - finding the right path
    • Mann M.P., Foster G.R., Rockstroh J.K., et al. The way forward in HCV treatment - finding the right path. Nat Rev Drug Discov 6 (2007) 991-1000
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 991-1000
    • Mann, M.P.1    Foster, G.R.2    Rockstroh, J.K.3
  • 10
    • 84862816908 scopus 로고    scopus 로고
    • Recent progress in the development of selected hepatitis C virus NS3-4A protease and NS5B polymerase inhibitors
    • Kwong A.D., McNair L., Jacobson I., et al. Recent progress in the development of selected hepatitis C virus NS3-4A protease and NS5B polymerase inhibitors. Curr Opin Pharmacol 8 (2008) 522-531
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 522-531
    • Kwong, A.D.1    McNair, L.2    Jacobson, I.3
  • 11
    • 33746230996 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of valopicitabine (NM283), a new nucleoside HCV polymerase inhibitor: results from a phase I/II dose-escalation trial in patients with HCV-1 infection
    • [abstract]
    • Zhou X.J., Afdhal N., Godofsky E., et al. Pharmacokinetics and pharmacodynamics of valopicitabine (NM283), a new nucleoside HCV polymerase inhibitor: results from a phase I/II dose-escalation trial in patients with HCV-1 infection. [abstract]. J Hepatol 42 (2005) 229A
    • (2005) J Hepatol , vol.42
    • Zhou, X.J.1    Afdhal, N.2    Godofsky, E.3
  • 12
    • 19944403750 scopus 로고    scopus 로고
    • First clinical results for a novel antiviral treatment for hepatitis C: a phase I/III dose escalation trial assessing tolerance, pharmacokinetics and antiviral activity on NM283, a novel antiviral treatment for hepatitis C
    • [abstract]
    • Godofsky E.W., Afdal N., Rustgi V., et al. First clinical results for a novel antiviral treatment for hepatitis C: a phase I/III dose escalation trial assessing tolerance, pharmacokinetics and antiviral activity on NM283, a novel antiviral treatment for hepatitis C. [abstract]. Gastroenterology 126 Suppl 2 (2004) A681
    • (2004) Gastroenterology , vol.126 , Issue.SUPPL. 2
    • Godofsky, E.W.1    Afdal, N.2    Rustgi, V.3
  • 13
    • 34548789741 scopus 로고    scopus 로고
    • Valopicitabine (NM283), alone or with peginterferon, compared to peginterferon/ribavirin (PEGIFN/RBV) retreatment in patients with HCV-1 infection and prior non-response to PEGIFN/RBV: one-year results
    • [abstract]
    • Afdhal N., O'Brian C., Godofsky E., et al. Valopicitabine (NM283), alone or with peginterferon, compared to peginterferon/ribavirin (PEGIFN/RBV) retreatment in patients with HCV-1 infection and prior non-response to PEGIFN/RBV: one-year results. [abstract]. J Hepatol 46 (2007) S5
    • (2007) J Hepatol , vol.46
    • Afdhal, N.1    O'Brian, C.2    Godofsky, E.3
  • 15
    • 49649094687 scopus 로고    scopus 로고
    • Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C
    • Roberts S.K., Cooksley G., Dore G.J., et al. Robust antiviral activity of R1626, a novel nucleoside analog: a randomized, placebo-controlled study in patients with chronic hepatitis C. Hepatology 48 (2008) 398-406
    • (2008) Hepatology , vol.48 , pp. 398-406
    • Roberts, S.K.1    Cooksley, G.2    Dore, G.J.3
  • 16
    • 49649125855 scopus 로고    scopus 로고
    • R1626 plus peginterferon alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin
    • Pockros P.J., Nelson D., Godofsky E., et al. R1626 plus peginterferon alfa-2a provides potent suppression of hepatitis C virus RNA and significant antiviral synergy in combination with ribavirin. Hepatology 48 (2008) 285-297
    • (2008) Hepatology , vol.48 , pp. 285-297
    • Pockros, P.J.1    Nelson, D.2    Godofsky, E.3
  • 17
    • 34548241862 scopus 로고    scopus 로고
    • In vitro antiviral interactions of a novel HCV inhibitor R1479 with interferon α2a, ribavirin and other HCV inhibitors
    • [abstract]
    • Jiang W.-R., Chiu S., Ali S., et al. In vitro antiviral interactions of a novel HCV inhibitor R1479 with interferon α2a, ribavirin and other HCV inhibitors. [abstract]. Hepatology 44 Suppl 1 (2006) 533A
    • (2006) Hepatology , vol.44 , Issue.SUPPL. 1
    • Jiang, W.-R.1    Chiu, S.2    Ali, S.3
  • 18
    • 46249092467 scopus 로고    scopus 로고
    • 84% end-of-treatment response (EOTR, week 48) achieved with R1626, peginterferon alfa 2a (40KD) and ribavirin for 4 weeks followed by the standard of care: Results of a phase 2a study in treatment-naïve HCV genotype 1 patients
    • [abstract]
    • Nelson D., Pockros P., Godofsky E., et al. 84% end-of-treatment response (EOTR, week 48) achieved with R1626, peginterferon alfa 2a (40KD) and ribavirin for 4 weeks followed by the standard of care: Results of a phase 2a study in treatment-naïve HCV genotype 1 patients. [abstract]. J Hepatol 48 Suppl 2 (2008) S371
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Nelson, D.1    Pockros, P.2    Godofsky, E.3
  • 19
    • 56849127356 scopus 로고    scopus 로고
    • High relapse rate seen at week 72 for patients treated with R1626 combination therapy
    • Pockros P., Nelson D., Godofsky E., et al. High relapse rate seen at week 72 for patients treated with R1626 combination therapy. Hepatology 48 (2008) 1349-1350
    • (2008) Hepatology , vol.48 , pp. 1349-1350
    • Pockros, P.1    Nelson, D.2    Godofsky, E.3
  • 20
    • 41349083638 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, safety and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy
    • [abstract]
    • Reddy R., Rodriguez-Torres M., Gane E., et al. Antiviral activity, pharmacokinetics, safety and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy. [abstract]. Hepatology 46 Suppl 1 (2007) 862A
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Reddy, R.1    Rodriguez-Torres, M.2    Gane, E.3
  • 21
    • 67650571603 scopus 로고    scopus 로고
    • Potent antiviral response to the HCV nucleoside polymerase inhibitor R7128 for 28 days with Peg-IFN and ribavirin: subanalysis by race/ethnicity, eight and HCV genotype
    • [abstract]
    • Rodriguez-Torres M., Lalezari J., Gane E., et al. Potent antiviral response to the HCV nucleoside polymerase inhibitor R7128 for 28 days with Peg-IFN and ribavirin: subanalysis by race/ethnicity, eight and HCV genotype. [abstract]. Hepatology 48 Suppl (2008) 1160A
    • (2008) Hepatology , vol.48 , Issue.SUPPL
    • Rodriguez-Torres, M.1    Lalezari, J.2    Gane, E.3
  • 22
    • 59149098021 scopus 로고    scopus 로고
    • Antiviral activity of the HCV nucleoside polymerase inhibitor R7128 in HCV genotype 2 and 3 prior non-responders; results of R7128 1500 mg BID with PEG-IFN and ribavirin for 28 days
    • [abstract]
    • Gane E., Rodriguez-Torres M., Nelson D., et al. Antiviral activity of the HCV nucleoside polymerase inhibitor R7128 in HCV genotype 2 and 3 prior non-responders; results of R7128 1500 mg BID with PEG-IFN and ribavirin for 28 days. [abstract]. Hepatology 48 Suppl 1 (2008) 1024A
    • (2008) Hepatology , vol.48 , Issue.SUPPL. 1
    • Gane, E.1    Rodriguez-Torres, M.2    Nelson, D.3
  • 24
    • 67649596234 scopus 로고    scopus 로고
    • In vitro antiviral activity and pharmacology of IDX184, a novel and potent inhibitor of HCV replication
    • [abstract]
    • Cretton-Scott E., Perigaud C., Peyrottes S., et al. In vitro antiviral activity and pharmacology of IDX184, a novel and potent inhibitor of HCV replication. [abstract]. J Hepatol 48 Suppl 2 (2008) S220
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Cretton-Scott, E.1    Perigaud, C.2    Peyrottes, S.3
  • 25
    • 67650626240 scopus 로고    scopus 로고
    • Accessed from Idenix website, Available at: Accessed February 14, 2009
    • Accessed from Idenix website, Available at:. www.indenix.com Accessed February 14, 2009
  • 26
    • 62949195680 scopus 로고    scopus 로고
    • Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees
    • Carrol S.S., Ludmerer S., Handt L., et al. Robust antiviral efficacy upon administration of a nucleoside analog to hepatitis C virus-infected chimpanzees. Antimicrob Agents Chemother 53 (2009) 926-934
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 926-934
    • Carrol, S.S.1    Ludmerer, S.2    Handt, L.3
  • 27
    • 63349109767 scopus 로고    scopus 로고
    • HCV796: a selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C
    • Kneteman N.M., How A.Y.M., Goa T., et al. HCV796: a selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C. Hepatology 49 (2009) 745-752
    • (2009) Hepatology , vol.49 , pp. 745-752
    • Kneteman, N.M.1    How, A.Y.M.2    Goa, T.3
  • 28
    • 36949021772 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of the non-nucleoside polymerase inhibitor, HCV-796: results of a randomized, double-blind, placebo-controlled, ascending single-dose study in healthy subjects
    • Chandra P., Moyer L., Harper D., et al. Safety and pharmacokinetics of the non-nucleoside polymerase inhibitor, HCV-796: results of a randomized, double-blind, placebo-controlled, ascending single-dose study in healthy subjects. J Hepatol 44 Suppl 2 (2006) S208-S209
    • (2006) J Hepatol , vol.44 , Issue.SUPPL. 2
    • Chandra, P.1    Moyer, L.2    Harper, D.3
  • 29
    • 34548285968 scopus 로고    scopus 로고
    • Antiviral activity of the non-nucleoside polymerase inhibitor, HCV-796, in combination with pegylated interferon alfa-2b in treatment-naïve patients with chronic HCV
    • [abstract]
    • Villano S.A., Raible D., Harper D., et al. Antiviral activity of the non-nucleoside polymerase inhibitor, HCV-796, in combination with pegylated interferon alfa-2b in treatment-naïve patients with chronic HCV. [abstract]. J Hepatol 46 (2007) S24
    • (2007) J Hepatol , vol.46
    • Villano, S.A.1    Raible, D.2    Harper, D.3
  • 30
    • 33947656594 scopus 로고    scopus 로고
    • Analysis of HCV NS5B genetic variants following monotherapy with HCV-796, a non-nucleoside polymerase inhibitor in treatment naïve HCV-infected patients
    • [abstract]
    • Villano S., Howe A., Raible D., et al. Analysis of HCV NS5B genetic variants following monotherapy with HCV-796, a non-nucleoside polymerase inhibitor in treatment naïve HCV-infected patients. [abstract]. Hepatology 44 Suppl 1 (2006) 607A
    • (2006) Hepatology , vol.44 , Issue.SUPPL. 1
    • Villano, S.1    Howe, A.2    Raible, D.3
  • 32
    • 67650598979 scopus 로고    scopus 로고
    • Pockros PJ, Rodriguez-Torres M, Villano S, et al. A phase 2, randomized study of HCV-796 in combination with PEG-Intron plus Rebetol (RBV) versus PEG-Intron plus RBV in hepatitis C virus genotype 1 infection. European Association for the Study of Liver Disease Annual Meeting. Copenhagen, Denmark. April 22-29, 2009.
    • Pockros PJ, Rodriguez-Torres M, Villano S, et al. A phase 2, randomized study of HCV-796 in combination with PEG-Intron plus Rebetol (RBV) versus PEG-Intron plus RBV in hepatitis C virus genotype 1 infection. European Association for the Study of Liver Disease Annual Meeting. Copenhagen, Denmark. April 22-29, 2009.
  • 33
    • 35748960801 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and antiviral effects of BILB 1941, a novel HCV RNA polymerase, after 5 days oral treatment in patients with chronic hepatitis C
    • [abstract]
    • Erhardt A., Wedemeyer H., Benhamou Y., et al. Safety, pharmacokinetics and antiviral effects of BILB 1941, a novel HCV RNA polymerase, after 5 days oral treatment in patients with chronic hepatitis C. [abstract]. J Hepatol 44 Suppl (2007) S222
    • (2007) J Hepatol , vol.44 , Issue.SUPPL
    • Erhardt, A.1    Wedemeyer, H.2    Benhamou, Y.3
  • 34
    • 67049085259 scopus 로고    scopus 로고
    • Antiviral activity of the HCV polymerase inhibitor PF-00868554 administered as monotherapy in HCV genotype 1 infected subjects
    • [abstract]
    • Hammond J.L., Rosario M.C., Wagner F., et al. Antiviral activity of the HCV polymerase inhibitor PF-00868554 administered as monotherapy in HCV genotype 1 infected subjects. [abstract]. Hepatology 48 Suppl 1 (2008) 267A
    • (2008) Hepatology , vol.48 , Issue.SUPPL. 1
    • Hammond, J.L.1    Rosario, M.C.2    Wagner, F.3
  • 35
    • 42349106424 scopus 로고    scopus 로고
    • GS-9190, a novel substituted imidazopyridine analogue, is a potent inhibitor of hepatitis C virus replication in vitro and remains active against known drug resistant mutants
    • [abstract]
    • Vliegen I., Paeshuyse J., Marbery E., et al. GS-9190, a novel substituted imidazopyridine analogue, is a potent inhibitor of hepatitis C virus replication in vitro and remains active against known drug resistant mutants. [abstract]. Hepatology 46 Suppl 1 (2007) 855A
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Vliegen, I.1    Paeshuyse, J.2    Marbery, E.3
  • 36
    • 41749085866 scopus 로고    scopus 로고
    • Antiviral, pharmacokinetic and safety data for GS 9190, a non-nucleoside HCV NS5b polymerase inhibitor, in a phase-1 trial in HCV genotype 1 infected subjects
    • [abstract]
    • Bavisotto L., Wang C.C., Jacobson I.M., et al. Antiviral, pharmacokinetic and safety data for GS 9190, a non-nucleoside HCV NS5b polymerase inhibitor, in a phase-1 trial in HCV genotype 1 infected subjects. [abstract]. Hepatology 46 Suppl 1 (2007) 255A
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Bavisotto, L.1    Wang, C.C.2    Jacobson, I.M.3
  • 37
    • 42349083141 scopus 로고    scopus 로고
    • Antiviral activity of the non-nucleoside polymerase inhibitor, VCH-759, in chronic hepatitis C patients: results from a randomized double blind placebo controlled ascending multiple dose study
    • [abstract]
    • Cooper C., Lawitz E.J., Ghali P., et al. Antiviral activity of the non-nucleoside polymerase inhibitor, VCH-759, in chronic hepatitis C patients: results from a randomized double blind placebo controlled ascending multiple dose study. [abstract]. Hepatology 46 Suppl 1 (2007) 864A
    • (2007) Hepatology , vol.46 , Issue.SUPPL. 1
    • Cooper, C.1    Lawitz, E.J.2    Ghali, P.3
  • 38
    • 67650571602 scopus 로고    scopus 로고
    • Results of safety, tolerability and pharmacokinetic phase I study of VCH-916, a novel polymerase inhibitor for HCV, following single ascending doses in healthy volunteers
    • Proulx L., Bourgault B., Chauret N., et al. Results of safety, tolerability and pharmacokinetic phase I study of VCH-916, a novel polymerase inhibitor for HCV, following single ascending doses in healthy volunteers. J Hepatol 48; Suppl 2 (2008) S320-S321
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Proulx, L.1    Bourgault, B.2    Chauret, N.3
  • 39
    • 67650613813 scopus 로고    scopus 로고
    • ANA598 (Anadys Pharmaceuticals). Available at: Accessed February 14, 2009
    • ANA598 (Anadys Pharmaceuticals). Available at:. www.anadyspharma.com Accessed February 14, 2009
  • 40
    • 46249112617 scopus 로고    scopus 로고
    • Potent antiviral activity of the HCV nucleoside polymerase inhibitor R7128 with PEG-IFN and ribavirin: interim results of R7128 500 mg BID for 28 days
    • [abstract]
    • Lalezari J., Gane E., Rodriguez-Torres M., et al. Potent antiviral activity of the HCV nucleoside polymerase inhibitor R7128 with PEG-IFN and ribavirin: interim results of R7128 500 mg BID for 28 days. [abstract]. J Hepatol 48 Suppl 2 (2008) S29
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Lalezari, J.1    Gane, E.2    Rodriguez-Torres, M.3
  • 41
    • 33947617864 scopus 로고    scopus 로고
    • Specific targeted antiviral therapy for hepatitis C
    • Sulkowski M.S. Specific targeted antiviral therapy for hepatitis C. Curr Gastroenterol Rep 9 (2007) 5-13
    • (2007) Curr Gastroenterol Rep , vol.9 , pp. 5-13
    • Sulkowski, M.S.1


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