Gα Minigenes Expressing C-terminal Peptides Serve as Specific Inhibitors of Thrombin-mediated Endothelial Activation

Journal of Biological Chemistry

Volumn 276, Issue 28, 2001, Pages 25672-25679

  Gilchrist, Annette ^a   Vanhauwe, Jurgen F ^a   Li, Anli ^a   Thomas, Tarita O ^a   Voyno Yasenetskaya, Tatyana ^b   Hamm, Heidi E ^a,b,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GENES; PROTEINS;

ENDOTHELIAL CELL; PROTEIN RECEPTORS;

BIOCHEMISTRY;

ADENOSINE A1 RECEPTOR; C TERMINAL PEPTIDE; G PROTEIN COUPLED RECEPTOR; GALPHA C TERMINAL PEPTIDE; GALPHA12 TERMINAL PEPTIDE; GALPHA13 TERMINAL PEPTIDE; GALPHAI C TERMINAL PEPTIDE; GALPHAI PEPTIDE; GALPHAQ C TERMINAL PEPTIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M2 RECEPTOR; PEPTIDE; PLASMID VECTOR; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DNA VECTOR; ENDOTHELIUM CELL; GALPHA MINIGENE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MINIGENE VECTOR; PLASMID MINIGENE VECTOR; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; CELL LINE; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

CELL LINE; ENDOTHELIUM, VASCULAR; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; SIGNAL TRANSDUCTION; THROMBIN;

EID: 0035854829     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100914200     Document Type: Article

References (73)

1. Aengevaeren, W. R. (1999) Atherosclerosis 147, S11-6
2. Bevilacqua, M. P., and Gimbrone, M. A. (1987) Semin. Thromb. Hemostasis 13, 425-433
3. Wu, K. K., and Thiagarajan, P. (1996) Annu. Rev. Med. 47, 315-331
4. Coughlin, S. R. (2000) Nature 407, 258-264
5. Preissner, K. T., Nawroth, P. P., and Kanse, S. M. (2000) J. Pathol. 190, 360-372
6. Baykal, D., Schmedtje, J. F., and Runge, M. S. (1995) Am. J. Cardiol. 75, (suppl.) 82B-87B
7. Brass, L. F., and Molino, M. (1997) Thromb. Haemostasis 78, 234-241
8. Rabiet, M. J., Plantier, J. L., and Dejana, E. (1994) Br. Med. Bull. 50, 936-945
9. Coughlin, S. R., Vu, T. K., Hung, D. T., and Wheaton, V. I. (1992) Semin. Thromb. Hemostasis 18, 161-166
10. Ishihara, H., Connolly, A. J., Zeng, D., Kahn, M. L., Zheng, Y. W., Timmons, C., Tram, T., and Coughlin, S. R. (1997) Nature 386, 502-506
11. Nystedt, S., Ramakrishnan, V., and Sundelin, J. (1996) J. Biol. Chem. 271, 14910-14915
12. Saifeddine, M., Al-Ani, B., Cheng, C. H., Wang, L., and Hollenberg, M. D. (1996) Br. J. Pharmacol. 118, 521-530
13. Sugama, Y., Tiruppathi, C., Offakidevi, K., Andersen, T. T., Fenton, J. W., and Malik, A. B. (1992) J. Cell Biol. 119, 935-944
14. Vischer, U. M., Barth, H., and Wollheim, C. B. (2000) Arterioscler. Thromb. Vasc. Biol. 20, 883-891
15. Langer, F., Morys-Wortmann, C., Kusters, B., and Storck, J. (1999) Br. J. Haematol. 105, 542-550
16. Senis, Y. A., Richardson, M., Tinlin, S., Maurice, D. H., and Giles, A. R. (1996) Br. J. Haematol. 93, 195-203
17. Tsopanoglou, N. E., and Maragoudakis, M. E. (1999) J. Biol. Chem. 274, 23969-23976
18. Ueno, A., Murakami, K., Yamanouchi, K., Watanabe, M., and Kondo, T. (1996) J. Immunol. 88, 76-81
19. Ellis, C. A., Malik, A. B., Gilchrist, A., Hamm, H., Sandoval, R., Voyno-Yasenetskaya, T., and Tiruppathi, C. (1999) J. Biol. Chem. 274, 13718-13727
20. Tiruppathi, C., Malik, A. B., Del Vecchio, P. J., Keese, C. R., and Giaever, I. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 7919-7923
21. Vouret-Craviari, V., Boquet, P., Pouyssegur, J., and Van Obberghen-Schilling, E. (1998) Mol. Biol. Cell 9, 2639-2653
22. Garcia, J. G., Verin, A. D., and Schaphorst, K. L. (1996) Semin. Thromb. Hemostasis 22, 309-315
23. Lum, H., and Malik, A. B. (1996) J. Physiol. Pharmacol. 74, 787-800
24. Malik, A. B., and Fenton, J. W. (1992) Semin. Thromb. Hemostasis 18, 193-199
25. Rabiet, M. J., Plantier, J. L., Rival, Y., Genoux, Y., Lampugnani, M. G., and Dejana, E. (1996) Arterioscler. Thromb. Vasc. Biol. 16, 488-496
26. Wang, H. S., Li, F., Runge, M. S., and Chaikof, E. L. (1997) J. Surg. Res. 68, 139-144
27. Coughlin, S. R. (1993) Thromb. Haemostasis 70, 184-187
28. Dennington, P. M., and Berndt, M. C. (1994) Clin. Exp. Pharmacol. Physiol. 21, 349-358
29. Bernatowicz, M. S., Klimas, C. E., Hartl, K. S., Peluso, M., Allegretto, N. J., and Seiler, S. M. (1996) J. Med. Chem. 39, 4879-4887
30. Brass, L. F. (1997) Thromb. Haemostasis 74, 499-505
31. Brass, L. F. (1997) Coron. Artery Dis. 8, 49-58
32. Conklin, R. B., Farfel, Z., Lustig, K. D., Julius, D., and Bourne, H. R. (1993) Nature 363, 274-276
33. Gilchrist, A., Mazzoni, M., Dineen, B., Dice, A., Linden, J., Dunwiddie, T., and Hamm, H. E. (1998) J. Biol. Chem. 273, 14912-14919
34. Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B., and Hoffmann, K. P. (1988) Science 241, 832-835
35. Rasenick, M. M., Watanabe, M., Lazarevic, M. B., Hatta, G., and Hamm, H. E. (1994) J. Biol. Chem. 269, 21519-21525
36. Gilchrist, A., Bünemann, M., Li, A., Hosey, M. M., and Hamm, H. E. (1999) J. Biol. Chem. 274, 6610-6616
37. Martin, E. L., Rens-Domiano, S., Schatz, P. J., and Hamm, H. E. (1996) J. Biol. Chem. 271, 361-366
38. Minshall, R. D., Tiruppathi, C., Vogel, S. M., Niles, W. D., Gilchrist, A., Hamm, H. E., and Malik, A. B. (2000) J. Cell Biol. 150, 1057-1070
39. Gerdes, H. H., and Kaether, C. (1996) FEBS Lett. 389, 44-47
40. Faure, M., Voyno-Yasenetskaya, T. A., and Bourne, H. R. (1994) J. Biol. Chem. 269, 7851-7854
41. Voyno-Yasenetskaya, T. A., Tkachuk, V. A., Cheknyova, E. G., Panchenko, M. P., Grigorian, G. Y., Vavrek, R. J., Stewart, J. M., and Ryan, U. S. (1989) FASEB J. 3, 44-51
42. Voyno-Yasenetskaya, T. A., Faure, M. P., Ahn, N. G., and Bourne, H. R. (1996) J. Biol. Chem. 271, 21081-21087
43. Xu, Y., Swerlick, R. A., Sepp, N., Bosse, D., Ades, E. W., and Lawley, T. J. (1994) J. Invest. Dermatol. 102, 833-837
44. Manolopoulos, G. V., Fenton, J. W., and Lelkes, P. I. (1997) Biochim. Biophys. Acta 1356, 321-332
45. Mizuno, O., Hirano, K., Nishimura, J., Kubo, C., and Kanaide, H. (2000) Eur. J. Pharmacol. 389, 13-23
46. Moore, T. M., Norwood, N. R., Creighton, J. R., Babal, P., Brough, G. H., Shasby, D. M., and Stevens, T., (2000) Am. J. Physiol. 279, L691-L698
47. Nguyen, L. T., Lum, H., Tiruppathi, C., and Malik, A. B. (1997) Am. J. Physiol. 273, C1756-C1763
48. Garcia, J. G. (1992) J. Lab. Clin. Med. 120, 513-519
49. Gohla, A., Offermanns, S., Wilkie, T. M., and Schultz, G. (1999) J. Biol. Chem. 274, 17901-17907
50. Ponimaskin, E., Behn, H., Adarichev, V., Voyno-Yasenetskay, T. A., Offermanns, S., and Schmidt, M. F. (2000) FEBS Lett. 478, 173-177
51. Buhl, A. M., Johnson, N. L., Dhanasekaran, N., and Johnson, G. L. (1995) J. Biol. Chem. 270, 24631-24634
52. Klages, B., Brandt, U., Simon, M. I., Schultz, G., and Offermanns, S. (1999) J. Cell Biol. 144, 745-754
53. Kranenburg, O., Poland, M., Van Horck, F. P., Drechsel, D., Hall, A., and Moolenaar, W. H. (1999) Mol. Biol. Cell 10, 1851-1857
54. Needham, L. K., and Rozengurt, E. (1998) J. Biol. Chem. 273, 14626-14632
55. Carbajal, J. M., Gratrix, M. L., Yu, C. H., and Schaeffer, R. C. (2000) Am. J. Physiol. Cell Physiol. 279, C195-204
56. Lopez-Ilasaca, M. (1998) Biochem. Pharmacol. 56, 269-277
57. Molino, M., Woolkalis, M. J., Reavey-Cantwell, J., Pratico, D., Andrade-Gordon, P., Barnathan, E. S., and Brass, L. F. (1997) J. Biol. Chem. 272, 11133-11141
58. Nakanishi-Matsui, M., Zheng, Y. W., Sulciner, D. J., Weiss, E. J., Ludeman, M. J., and Coughlin, S. R. (2000) Nature 404, 609-613
59. Cupit, L. D., Schmidt, V. A., and Bahou, W. F. (1999) Trends Cardiovasc. Med. 9, 42-48
60. Benka, M. L., Lee, M., Wang, G. R., Buckman, S., Burlacu, A., Cole, L., Depina, A., Dias, P., Granger, A., and Grant, B. (1995) FEBS Lett. 363, 49-52
61. Baffy, G., Yang, L., Raj, S., Manning, D. R., and Williamson, J. R. (1994) J. Biol. Chem. 269, 8483-8487
62. Hung, D. T., Wong, Y. H., Vu, T. K., and Coughlin, S. R. (1992) J. Biol. Chem. 267, 20831-20834
63. Offermanns, S., Laugwitz, K. L., Spicher, K., and Schultz, G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 504-508
64. Aragay, A. M., Collins, L. R., Post, G. R., Watson, A. J., Feramisco, J. R., Brown, J. H., and Simon, M. I. (1995) J. Biol. Chem. 270, 20073-20077
65. Hamm, H. E., and Gilchrist, A. (1996) Cur. Opin. Cell Biol. 8, 189-196
66. Hamm, H. E. (1998) J. Biol. Chem. 273, 669-672
67. Patterson, C. E., and Garcia, J. G. (1994) Blood Coagul. Fibrinolysis 5, 63-72
68. Ghahremani, M. H., Forget, C., and Albert, P. R. (2000) Mol. Cell. Biol. 20, 1497-1506
69. Igishi, T., and Gutkind, J. S. (1998) Biochem. Biophys. Res. Commun. 244, 5-10
70. Nagao, M., Yamauchi, J., Kaziro, Y., and Itoh, H. (1998) J. Biol. Chem. 273, 22892-22898
71. Blahos, J., Fischer, T., Brabet, I., Stauffer, D., Rovelli, G., Bockaert, J., and Pin, J. P. (2001) J. Biol. Chem. 276, 3262-3269
72. Ho, M. K., and Wong, Y. H. (2000) Mol. Pharmacol. 58, 993-1000
73. Bae, H., Anderson, K., Flood, L. A., Skiba, N. P., Hamm, H. E., and Graber, S. G. (1997) J. Biol. Chem. 272, 32071-32077