Macrophages treated with particulate matter PM2.5 induce selective neurotoxicity through glutaminase-mediated glutamate generation

Journal of Neurochemistry

Volumn 134, Issue 2, 2015, Pages 315-326

  Liu, Fang ^a   Huang, Yunlong ^b,c   Zhang, Fang ^a   Chen, Qiang ^b,c   Wu, Beiqing ^b,c   Rui, Wei ^a   Zheng, Jialin C ^b,c   Ding, Wenjun ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

blood brain barrier; glutamate; glutaminase; macrophage; neurotoxicity; PM 2.5

Indexed keywords

CELL ANTIGEN; DIZOCILPINE; GLUTAMIC ACID; GLUTAMINASE; NEURONAL ANTIGEN; PROTEIN ZO1; PROTEIN ZO2; UNCLASSIFIED DRUG; AIR POLLUTANT; PARTICULATE MATTER;

AIR POLLUTANT; AIR POLLUTION; ANIMAL CELL; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIAL CELL; CELL LOSS; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL VIABILITY; CHINA; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO; ENDOTHELIUM CELL; EXOSOME; FETUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MICROGLIA; MONOCYTE; MONOLAYER CULTURE; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; SUPERNATANT; TIGHT JUNCTION; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; BIOSYNTHESIS; CAPILLARY PERMEABILITY; CELL CULTURE; FLUORESCENT ANTIBODY TECHNIQUE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; NERVE CELL; NEUROTOXICITY SYNDROMES; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TOXICITY; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

AIR POLLUTANTS; ANIMALS; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOTHELIUM, VASCULAR; FLUORESCENT ANTIBODY TECHNIQUE; GLUTAMIC ACID; GLUTAMINASE; HUMANS; MACROPHAGES; NEURONS; NEUROTOXICITY SYNDROMES; PARTICULATE MATTER; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84936774053     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13135     Document Type: Article

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