Inflammasome activation in airway epithelial cells after multi-walled carbon nanotube exposure mediates a profibrotic response in lung fibroblasts

Particle and Fibre Toxicology

Volumn 11, Issue 1, 2014, Pages

  Hussain, Salik ^a   Sangtian, Stacey ^a   Anderson, Shamika M ^a   Snyder, Ryan J ^a   Marshburn, Jamie D ^a   Rice, Annette B ^a   Bonner, James C ^b   Garantziotis, Stavros ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Fibrosis; Human bronchial epithelia; Multi walled carbon nanotubes; Nanotoxicity; NLRP3 inflammasome; Pyroptosis

Indexed keywords

ANTIOXIDANT; CATHEPSIN B INHIBITOR; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18 ANTIBODY; INTERLEUKIN 1BETA ANTIBODY; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; INTERLEUKIN 8 ANTIBODY; MESSENGER RNA; MULTI WALLED NANOTUBE; NEUTRALIZING ANTIBODY; OSTEOPONTIN; PROCOLLAGEN; PROCOLLAGEN 1; SMALL INTERFERING RNA; TENASCIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CATHEPSIN B; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; RANTES; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

AIRWAY REMODELING; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CELL DAMAGE; CELLULAR PARAMETERS; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG FIBROBLAST; LUNG FIBROSIS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PYROPTOSIS; RESPIRATORY EPITHELIUM; CELL DEATH; CELL PROLIFERATION; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME RELEASE; GENE EXPRESSION; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION;

ANTIOXIDANTS; APOPTOSIS; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NANOTUBES, CARBON; PULMONARY FIBROSIS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SUSPENSIONS;

EID: 84902966500     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-11-28     Document Type: Article

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