Trafficking of surface-linked and encapsulated liposomal antigens in macrophages: An immunocytochemical study

Journal of Histochemistry and Cytochemistry

Volumn 49, Issue 11, 2001, Pages 1407-1420

  Fortin, A ^a   Lagace J ^a   Therien H M ^a  

^a UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

Author keywords

Adjuvant; Antigen presentation; Immunocytochemistry; Liposomes; Macrophage; Subcellular structure

Indexed keywords

ANTIGEN; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OVOTRANSFERRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN DETECTION; ANTIGEN PRESENTATION; ARTICLE; CELL STRUCTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENCAPSULATION; FEMALE; HUMORAL IMMUNITY; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034783205     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540104901109     Document Type: Article

References (50)

1. Antigen incorporation into liposomes results in the enhancement of IL-4 and IgG1 secretion: Evidence for preferential expansion of Th2-cells cytokines
2. Immunologic presentation of liposomal antigens
3. Liposomes containing lipid A as a potent non-toxic adjuvant
4. Vesicles bearing MHC class II molecules mediate transfer of antigen from antigen-presenting cells to CD4+ T cells
5. How MHC class II molecules reach the endocytic pathway
6. Lipopeptide immunization without adjuvant induces potent and long lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees
7. Heat shock protein-based therapeutic strategies against human immunodeficiency virus type I infection
8. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
9. Human 60-kDa heat-shock protein: A danger signal to the immune system
10. Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors
11. Processed antigen binds to newly synthesized MHC class II molecules in antigen-specific lymphocytes
12. Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules
13. Differential activation of cell-mediated immune functions by encapsulated and surface-linked liposomal antigens
14. Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules
15. Interstitial lung macrophages interact with dendritic cells to resent antigenic peptides derived from particulate antigens to T cells
16. The immunological adjuvant and vaccine carrier properties of liposomes
17. Liposomal formulations of synthetic MUC1 peptides: Effect of encapsulation versus surface display of peptides on immune response
18. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules
19. Liposome-encapsulated antigens engender lysosomal processing for class-II MHC presentation and cytosolic processing for class-I presentation
20. In vitro fusion of rabbit liver Golgi membranes with liposomes
21. The effect of surface-coupled antigen of liposomes in immunopotentiation
22. Covalent coupling of monoclonal antibodies and protein A to liposomes: Specific interaction with cells in vitro and in vivo. A synthesis of dipalmitoyl phosphatidylethanolamine 3-(2-pyridyl-dithio) propionate(DPPE-DTP)
23. Tolerance, danger and the extended family
24. Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses
25. Soluble proteins delivered to dendritic cells via pH-sensitive liposomes induce primary cytotoxic T lymphocyte in vitro
26. The HSC73 molecular chaperone: Involvement in MHC class II antigen presentation
27. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
28. Macropinosome maturation and fusion with tubular lysosomes in macrophages
29. Trafficking of liposomal antigen to the trans-Golgi of murine macrophages requires both liposomal lipid and liposomal protein
30. B lymphocytes secrete antigen-presenting vesicles
31. Effect of a lipopeptidic formulation on macrophage activation and peptide presentation to T cells
32. Cell-free tumor antigen peptide-based cancer vaccines
33. Liposomal adjuvanticity effect of encapsulation and surface-linkage on antibody production and proliferative response
34. The dendritic cell system and its role in immunogenicity
35. The role of macrophages in the immuno-adjuvant effect of liposomes: Effect of elimination of splenic macrophages on the immune response against intravenously injected liposome-associated albumin antigen
36. From naive to memory T cells
37. Liposomal vaccine: Influence of antigen association on the kinetics of the humoral response
38. Differential biodistribution of encapsulated and surface-linked antigens
39. Molecular characterization of dendritic cells-derived exosomes. Selective accumulation of the heat shock protein hsc73
40. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake
41. Antibody responses to liposomes-associated antigen
42. Immunoadjuvant activities of liposomes: Two different macrophage-mediated mechanisms
43. Liposome mediated immunoprotentiation and immunomodulation
44. Association of an albumin antigen with phosphatidylcholine liposomes alters the nature of immunoglobulin produced during the immune response against the antigen
45. Does the membrane's physical state control the expression of heat shock and other genes
46. Isoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartments
47. Kinetics and intracellular pathways required for major histocompatibility complex II-peptide loading and surface expression of a fluorescent hapten-protein conjugate in murine macrophages
48. Proteolysis and class I major histocompatibility complex antigen presentation
49. In vivo production of heat shock protein in mouse peritoneal macrophages by administration of lipopolysaccharide
50. Eradication of established murine tumors using a novel cell-free vaccine: Dendritic cell-derived exosomes