RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

PLoS Pathogens

Volumn 11, Issue 6, 2015, Pages

  Ptaschinski, Catherine ^a   Mukherjee, Sumanta ^a,d   Moore, Martin L ^b   Albert, Mareike ^c,e   Helin, Kristian ^c   Kunkel, Steven L ^a   Lukacs, Nicholas W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d BRISTOL MYERS SQUIBB   (United States)

^e MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE KDM5B; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; DNA BINDING PROTEIN; KDM5B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED DENDRITIC CELL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; GENE EXPRESSION; HISTONE DEMETHYLATION; HISTOPATHOLOGY; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IMMUNE RESPONSE; INFLAMMATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL VIRUS INFECTION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CELL CULTURE; COCULTURE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; IMMUNOLOGY; INNATE IMMUNITY; TRANSGENIC MOUSE;

MUS; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; IMMUNITY, INNATE; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84936770677     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004978     Document Type: Article

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