PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis

Chromosoma

Volumn 112, Issue 3, 2003, Pages 124-132

  Madsen, Bente ^a   Tarsounas, Madalena ^b,d   Burchell, Joy M ^a   Hall, Debbie ^a   Poulsom, Richard ^c   Taylor Papadimitriou, Joyce ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b Clare Hall Laboratories   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d Aventis Slotsmarken 13   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEAR PROTEIN; PLU 1 PROTEIN; REPRESSOR PROTEIN; TESTIS CANCER ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ADULTHOOD; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL FRACTIONATION; CELL NUCLEUS; CHROMATIN; CONTROLLED STUDY; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MEIOSIS; MITOSIS; MOUSE; NONHUMAN; PACHYTENE; POSTNATAL DEVELOPMENT; PROPHASE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SOMATIC CELL; SPERMATOGONIUM; TESTIS CELL; TESTIS DEVELOPMENT; TRANSCRIPTION TERMINATION;

ANIMALS; CELL FRACTIONATION; CHROMATIN; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MALE; MEIOSIS; MICE; NEOPLASM PROTEINS; NUCLEAR PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; SPERMATOGONIA; TESTIS;

EID: 0242468568     PISSN: 00095915     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00412-003-0252-6     Document Type: Article

References (36)

1. Aasland R, Gibson TJ, Stewart AF (1995) The PHD finger: Implications for chromatin mediated transcriptional regulation. Trends Biol Sci 20:56-59
2. Agulnick AI, Mitchell MJ, Mattei MB, Lerner JL, Woods DR, Bishop CE (1994) A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatability antigens. Hum Mol Genet 3:873-978
3. Barrett A, Madsen B, Copier J, Lu PJ, Cooper L, Scibetta AG, Burchell J, Taylor-Papadimitriou J (2002) PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: A new cancer/testis antigen? Int J Cancer 101:581-585
4. Bellve AR, Cavicchia JC, Millette CF, O'Brien DA, Bhatnagar YM, Dym M. (1977) Spermatogenic cells of the prepuberal mouse: Isolation and morphological characterization. J Cell Biol 74:68-85
5. Chen YT, Old LJ (1999) Cancer-testis antigens: Targets for cancer immunotherapy. Cancer J Sci Am 5:16-17
6. Clermont Y (1972) Kinetics of spermatogenesis in mammals: Seminiferous epithelium cycle and spermatogonial renewal. Physiol Rev 52:197-236
7. Cohen PE, Pollard JW (2001) Regulation of meiotic recombination and prophase I progression in mammals. Bioessays 23:996-1009
8. Dallas PB, Pacchine S, Wilsker D, Bowrin V, Kobayashi R, Moran E (2000) The human SWI/SSNF complex protein, p270, is an ARID family member with nonsequence-specific DNA binding activity. Mol Cell Biol 20:3137-3146
9. De Plaen E, Arden K, Traversari C, Gaforio JJ, Szikora JP, De Smet C, Brasseur F, Van Der Bruggen P, Lethe B, Lurquin C et al. (1994) Structure, chromosomal localization and expression of 12 genes of the MAGE family. Immunogenetics 40:360-369
10. De Wit NJW, Weidle UH, Ruiter DJ, Van Muijen GNP (2002) Expression profiling of MMA-1A and splice variant MMA-1B: New cancer/testis antigens identified in human melanoma. Int J Cancer 98:547-553
11. Dobson MJ, Pearlman RE, Karaiskakis A, Spyropoulos B, Moens PB (1994) Synaptonemal complex proteins: Occurrence, epitope mapping and chromosome disjunction. J Cell Sci 107:2749-2760
12. Fazon et al. 1993
13. Goedecke W, Eijpe M, Offenberg HH, Van Aalderen M, Heyting C (1999) Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis. Nat Genet 23:194-198
14. Gregory et al. 1996
15. Herrsacher RF, Kaplan MH, Leisz DL, Das C, Scheuermann R, Tucker PW (1995) The immunoglobulin heavy chain matrix-associating regions are bound by Bright: A B cell specific transactivator that describes a new DNA binding protein family. Genes Dev 9:3067-3082
16. Huckins C, Oakberg EF (1978) Morphological and quantitative analysis of spermatogonia in mouse testes, using whole-mounted seminiferous tubules. The normal testes. Anat Rec 192:519-528
17. Huh S, Hatini V, Marcus RC, Li SC, Lai E (1999) Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression. Dev Biol 211:53-63
18. Lu PJ, Sundquist K, Baeckstrom D, Poulsom R, Hanby A, Meier-Ewert S, Jones T, Michell M, Pitha-Rowe P, Freemont P (1999) A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J Biol Chem 274:15633-15645
19. Madsen B, Poulson R, Hall D, Lu PJ, Scott K, Shaw A, Burchell J, Freemont P, Taylor-Papadimitriou J (2002) Characterisation and developmental expression of Mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Mech Dev Gene Expression Patterns 2:275-282
20. Moens PB (1995) Histones H1 and H4 of surface-spread meiotic chromosomes. Chromosoma 104:169-174
21. Padmore R, Cao L, Kleckner N (1991) Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae. Cell 66:1239-1256
22. Peters HNA, Balling RQ (1998) Pax genes and organogenesis: Pax9 meets tooth development. Eur J Oral Sci 106:38-43
23. Peters AH, Plug AW, Van Vugh MJ, De Boer P (1997) A drying-down technique for the spreading of mammalian meiocytes from the male and female germline. Chromosome Res 5:66-68
24. Poulsom R, Longcroft JM, Jeffrey RE, Rogers LA, Steel JH (1998) A robust method for isotopic riboprobe in situ hybridisation to localise mRNAs in routine pathology specimens. Eur J Histochem 42:121-132
25. Quadbeck-Seeger C, Wanner G, Huber S, Kahmann R, Kamper J (2000) A protein with similarity to the retinoblastoma binding protein 2 acts specifically as a repressor for gene regulated by the b mating type locus in Ustilago maydis. Mol Microbiol 38:154-166
26. Roeder GS (1997) Meiotic chromosomes: It takes two to tango. Genes Dev 11:2600-2621
27. Saha V, Chaplin T, Gregorini A, Ayton, Young BD (1995) The leukemia-associated protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci U S A 92:9737-9741
28. Senior PV, Beck F, Walker RA, Varley JM (1988) The localization of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse: An in situ hybridization and immunocytochemical study. Development 104:431-446
29. Stassen MJ, Bailey D, Nelson S, Chinwalla V, Harte P (1995) The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech Dev 52:209-223
30. Takei Y, Swietlik M, Tanoue A, Tsujimoto G, Kouzarides T, Laskey R (2001) MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3. EMBO Rep 2:119-123
31. Tan K, Shaw AL, Madsen B, Jensen K, Taylor-Papadimitriou J, Freemont PS (2003) Human PLU-1 has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J Biol Chem Submitted
32. Tarsounas M, Moens PB (2001) Checkpoint and DNA-repair proteins are associated with the cores of mammalian meiotic chromosomes. Curr Top Dev Biol 51:109-134
33. Tarsounas M, Pearlman RE, Moens PB (1999) Meiotic activation of rat pachytene spermatocytes with okadaic acid: The behaviour of synaptonemal complex components SYN1/SCP1 and COR1/SCP3. J Cell Sci 112:423-434
34. Tarsounas M, Davies D, West SC (2003) BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 22:1115-1123
35. Van Den Eynde B, Peeters O, De Backer O, Gaugler B, Lucas S, Boon T (1995) A new family of genes coding for an antigen recognised by autologous cytolytic T lymphocytes on a human melanoma. J Exp Med 182:689-698
36. Wilsker D, Patsialou A, Dallas PB, Moran E (2002) ARID proteins: A diverse family of DNA binding proteins implicated in the control of cell growth, differentiation and development. Cell Growth Differ 13:95-106