A major lung CD103 (αE)-β7 integrin-positive epithelial dendritic cell population expressing langerin and tight junction proteins

Journal of Immunology

Volumn 176, Issue 4, 2006, Pages 2161-2172

  Sung, Sun Sang J ^a,b   Fu, Shu Man ^a   Edward Rose Jr , C ^a   Gaskin, Felicia ^a   Ju, Shyr Te ^a   Beaty, Steven R ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; COMPLEMENTARY DNA; CYTOKINE; INTERLEUKIN 12; LANGERIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; ASTHMA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; FLOW CYTOMETRY; IMMUNOFLUORESCENCE MICROSCOPY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

EID: 32044465280     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.4.2161     Document Type: Article

References (62)

1. Steinman, R. M. 2003. Some interfaces of dendritic cell biology. APMIS 111: 675-697.
2. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392: 245-252.
3. Holt, P. G., and J. W. Upham. 2004. The role of dendritic cells in asthma. Curr. Opin. Allergy Clin. Immunol. 4: 39-44.
4. Slumhles, P. A., J. W. Upham, and P. G. Holt. 2003. Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract. APMIS 111: 741-755.
5. Sundquist, M., C. Johansson, and M. J. Wick. 2003. Dendritic cells as inducers of antimicrobial immunity in vivo. APMIS 111: 715-724.
6. + dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med 201: 981-991.
7. Schon-Hegrad, M. J. Oliver, P. McMenamin, and P. Holt. 1991. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (1a)- bearing dendritic cells (DC) in the conducting airways. J. Exp. Med. 173: 1345-1356.
8. Sertl, K., T. Takemura, E. Tschachler, V. J. Ferrans, M. A. Kaliner, and E. M. Shevach. 1986. Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura. J. Exp. Med. 163: 436-451.
9. Gong, J., K. McCarthy, J. Telford, T. Tamatani, M. Miyasaka, and E. Schneeberger. 1992. Intraepithelial airway dendritic cells: a distinct subset of pulmonary dendritic cells obtained by microdissection. J. Exp. Med. 175: 797-807.
10. Holt, P. G., S. Haining, D. J. Nelson, and J. D. Sedgwick. 1994. Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J. Immunol. 153: 256-261.
11. McWilliam, A. S., D. Nelson, J. A. Thomas, and P. G. Holt. 1994. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J. Exp. Med. 179: 1331-1336.
12. + dendritic cells shift dynamically from lung to lymph node after an airway challenge with soluble antigen. J. Exp. Med. 181: 1275-1283.
13. Vermnelen, K. Y., I. Carro-Muino, B. N. Lambrecht, and R. A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193: 51-60.
14. Byersdorfer, C. A., and D. D. Chaplin. 2001. Visualization of early APC/T cell interactions in the mouse lung following intranasal challenge. J. Immunol. 167: 6756-6764.
15. Huh, J. C., D. H. Strickland, F. L. Jahnsen, D. J. Turner, J. A. Thomas, S. Napoli, I. Tobagus, P. A. Stumbles, P. D. Sly, and P. G. Holt. 2003. Bidirectional interactions between antigen-bearing respiratory tract dendritic cells (DCs) and T cells precede the late phase reaction in experimental asthma: DC activation occurs in the airway mucosa hut not in the lung parenchyma. J. Exp. Med. 198: 19-30.
16. Henri, S., D. Vremec, A. Kamath, J. Wailhman, S. Williams, C. Benoist, K. Burnham, S. Saeland, E. Handman, and K. Shortman. 2001. The dendritic cell populations of mouse lymph nodes. J. Immunol. 167: 741-748.
17. 7 integrins define a subset of dendritic cells in peripheral lymph nodes with unique adhesive and antigen uptake properties J. Immunol. 172: 282-291.
18. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J. Exp. Med. 194: 1171-1178.
19. Asselin-Paturel, C., A. Boonstra, M. Dalod, I. Durand, N. Yessaad, C. Dezutter-Dambuyant, A. Vicari, A. O'Garra, C. Biron, P. Briere, and G. Trinchieri. 2001. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2: 1144-1150.
20. Blasius, A., W. Vermi, A. Krug, F. Facchetti, M. Cella, and M. Colonna. 2004. A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-α. Blood 103: 4201-4206.
21. Asselin-Paturel, C., G. Brizard, J. J. Pin, F. Briere, and G. Trinchieri. 2003. Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. Immunol. 171: 6466-6477.
22. de Heer, H. J., H. Hammad, T. Soullie, D. Hijdra, N. Vos, M. A. M. Willart, H. C. Hoogsteden, and B. N. Lambrecht. 2004. Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen. J. Exp. Med. 200: 89-98.
23. Pollard, A. M., and M. F. Lipscomb. 1990. Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells. J. Exp. Med. 172: 159-167.
24. Stumbles, P. A., J. A. Thomas, C. L. Pimm, P. T. Lee, T. J. Venaille, S. Proksch, and P. G. Holt. 1998. Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J. Exp. Med. 188: 2019-2031.
25. Gonzalez-Juarrero, M., and I. M. Orme. 2001. Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis. Infect. Immun. 69: 1127-1133.
26. Cochand, L., P. Isler, F. Songeon, and L. P. Nicod. 1999. Human lung dendritic cells have an immature phenotype with efficient mannose receptors. Am. J. Respir. Cell Mol. Biol. 21: 547-554.
27. Masten, B. J., and M. F. Lipscomb. 1999. Comparison of lung dendritic cells and B cells in stimulating naive antigen-specific T cells. J. Immunol. 162: 1310-1317.
28. Masten, B. J., G. K. Olson, D. F. Kusewitt, and M. F. Lipscomb. 2004. Flt3 ligand preferentially increases the number of functionally active myeloid dendritic cells in the lungs of mice. J. Immunol. 172: 4077-4083.
29. von Garnier, C., L. Filgueira, M. Wikstrom, M. Smith, J. A. Thomas, D. H. Strickland, P. G. Holt, and P. A. Stumbles. 2005. Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract. J. Immunol. 175: 1609-1618.
30. Vremec, D., and K. Shortman. 1997. Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J. Immunol. 159: 565-573.
31. Penna, G., M. Vulcano, S. Sozzani, and L. Adorini. 2002. Differential migration behavior and chemokine production by myeloid and plasmacytoid dendritic cells. Hum. Immunol. 63: 1164-1171.
32. Turnbull, E. L., U. Yrlid, C. D. Jenkins, and G. G. MacPherson. 2005. Intestinal dendritic cell subsets: differential effects of systemic TLR4 stimulation on migratory fate and activation in vivo. J. Immunol. 174: 1374-1384.
33. Sung, S. J., C. E. Rose, and S. M. Fu. 2001. Intratracheal priming with ovalbumin- and ovalbumin 323-339 peptide-pulsed dendritic cells induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation. J. Immunol. 166: 1261-1271.
34. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176: 1693-1702.
35. + regulatory T cells by antigen-processing dendritic cells. J. Exp. Med. 198: 235-247.
36. Li, C. and W. H. Wong. 2003. DNA-chip analyzer (dChip). In The Analysis of Gene Expression Data: Methods and Software. G. Pannigiani, E. S. Garrett, R. Irizarry, and S. L. Zeger, eds. Springer, New York, p. 5.1-5.21.
37. 7 by a major subpopulation of dendritic cells in mice. Eur. J. Immunol. 23: 3365-3368.
38. E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph. Eur. J. Immunol. 30: 1527-1537.
39. Hayday, A. C., S. Roberts, and E. Ramsburg. 2000. γδ cells and the regulation of mucosal immune responses. Am. J. Respir. Crit. Care Med. 162: S161-S163.
40. Yonekawa, K., and J. M. Harlan. 2005. Targeting leukocyte integrins in human diseases. J. Leukocyte Biol. 77: 129-140.
41. Dong, S., and R. Colin Hughes. 1997. Macrophage surface glycoproteins binding to galectin-3 (Mac-2-antigen). Glycoconjugate J. 14: 267-274.
42. Curiel, T. J., S. Wei, H. Dong, X. Alvarez, P. Cheng, P. Mottram, R. Krzysiek, K. L. Knutson, B. Daniel, M. C. Zimmermann, et al. 2003. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat. Med. 9: 562-567.
43. Crocker, P. R. 2002. Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling. Curr. Opin. Struct. Biol. 12: 609-615.
44. Zhang, J. Q., B. Biedermann, L. Nitschke, and P. R. Crocker. 2004. The murine inhibitory receptor mSiglec-E is expressed broadly on cells of the innate immune system whereas mSiglec-F is restricted to eosinophils. Eur. J. Immunol. 34: 1175-1184.
45. Holt, P., J. Oliver, N. Bilyk, C. McMenamin, P. McMenamin, G. Kraal, and T. Thepen. 1993. Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages. J. Exp. Med. 177: 397-407.
46. Hochrein, H., K. Shortman, D. Vremec, B. Scott, P. Hertzog, and M. O'Keeffe. 2001. Differential Production of IL-12, IFN-α, and IFN-γ mouse dendritic cell sunsets. J. Immunol. 166: 5448-5455.
47. Reis e Sousa, C. 2004. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 16: 27-34.
48. Valladeau, J., O. Ravel, C. Dezutter-Dambuyant, K. Moore, M. Kleijmeer, Y. Liu, V. Duvert-Frances, C. Vincent, D. Schmitt, J. Davoust, et al. 2000. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12: 71-81.
49. Hunger, R. E., P. A. Sieling, M. T. Ochoa, M. Sugaya, A. E. Burdick, T. H. Rea, P. J. Brennan, J. T. Belisle, A. Blauvelt, S. A. Porcelli, and R. L. Modlin. 2004. Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells. J. Clin. Invest. 113: 701-708.
50. Valladeau, J., V. Clair-Moninot, C. Dezutter-Dambuyant, J. J. Pin, A. Kissenpfennig, M. G. Mattei, S. Ait-Yahia, E. E. Bates, B. Malissen, F. Koch, et al. 2002. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphotd tissues. J. Immunol. 168: 782-792.
51. Takahara, K., Y. Omatsu, Y. Yashima, Y. Maeda, S. Tanaka, T. Iyoda, B. E. Clausen, K. Matsubara, J. Letterio, R. M. Steinman, et al. 2002. Identification and expression of mouse Langerin (CD207) in dendritic cells. Int. Immunol. 14: 433-444.
52. Miyoshi, J., and Y. Takai. 2005. Molecular perspective on tight-junction assembly and epithelial polarity. Adv. Drug. Deliv. Rev. 57: 815-855.
53. Hayday, A., and R. Tigelaar. 2003. Immunoregulation in the tissues by γδ T cells. Nat. Rev. Immunol. 3: 233-242.
54. high dendritic cell subsets as revealed by baseline gene expression patterns. J. Immunol. 171: 47-60.
55. Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515-526.
56. Cheng, P., Y. Nefedova, L. Miele, B. A. Osborne, and D. Gabrilovich. 2003. Notch signaling is necessary but not sufficient for differentiation of dendritic cells. Blood 102: 3980-3988.
57. Weijzen, S., M. P. Velders, A. G. Elmishad, P. E. Bacon, J. R. Panella, B. J. Nickoloff, L. Miele, and W. M. Kast. 2002. The notch ligand jagged-1 is able to induce maturation of monocyte-derived human dendritic cells. J. Immunol. 169: 4273-4278.
58. Reseigno, M., M. Urbano, B. Valzasina, M. Francolini, G. Rotta, R. Bonasio, F. Granucci, J. P. Kraehenbuhl, and P. Ricciardi-Castagnoli. 2001. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat. Immunol. 2: 361-367.
59. Fujita, H., A. Asahina, M. Sugaya, K. Nakamura, P. Gao, H. Fujiwara, and K. Tamaki. 2005. Differential production of Th1- and Th2-type chemokines by mouse Langerhans cells and splenic dendritic cells. J. Invest. Dermatol. 124: 343-350.
60. Suda, T., K. McCarthy, Q. Vu, J. McConnack, and E. E. Schneeberger. 1998. Dendritic cell precursors are enriched in the vascular compartment of the lung. Am. J. Respir. Cell Mol. Biol. 19: 728-737.
61. Sallusto, F., M. Cella, C. Danieli, and A. Lanzavecchia. 1995. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J. Exp. Med. 182: 389-400.
62. Radhakrishnan, S., K. Iijima, T. Kobayashi, M. Rodriguez, H. Kita, and L. R. Pease. 2004. Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody. J. Immunol. 173: 1360-1365.