East Asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina possible roles of reactive aldehydes and implications of alcohol flushing syndrome

Circulation

Volumn 131, Issue 19, 2015, Pages 1665-1673

  Mizuno, Yuji ^a   Harada, Eisaku ^a   Morita, Sumio ^a,b   Kinoshita, Kenji ^c   Hayashida, Mariko ^c   Shono, Makoto ^a   Morikawa, Yoshinobu ^d   Murohara, Toyoaki ^b   Nakayama, Masafumi ^e   Yoshimura, Michihiro ^f   Yasue, Hirofumi ^a  

^a Division of Cardiovascular Medicine   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^d Nara City Hospital   (Japan)

^e Nakayama Cardiovascular Clinic   (Japan)

^f JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alcohol; Aldehyde dehydrogenase; Coronary spasm; Coronary spastic angina

Indexed keywords

ACETYLCHOLINE; ALDEHYDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; URIC ACID; ALCOHOL; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN;

ADULT; AGED; ALCOHOL FLUSHING SYNDROME; ALDEHYDE DEHYDROGENASE ISOENZYME 1B GENE; ALDEHYDE DEHYDROGENASE ISOENZYME 2 GENE; ANGINA PECTORIS; ANGIOGRAPHY; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; CORONARY SPASTIC ANGINA; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC VARIABILITY; GENOTYPE; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SMOKING; ANGIOCARDIOGRAPHY; BLOOD; CHEMICALLY INDUCED; CORONARY ARTERY SPASM; CORONARY BLOOD VESSEL; DEFICIENCY; DIAGNOSTIC USE; ENZYMOLOGY; EPIDEMIOLOGY; ETHNOLOGY; FLUSHING; GENETICS; INTRAARTERIAL DRUG ADMINISTRATION; JAPAN; LIPID PEROXIDATION; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; RADIOGRAPHY; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ACETYLCHOLINE; AGED; ALDEHYDE DEHYDROGENASE; ALDEHYDES; CHOLESTEROL, HDL; CORONARY ANGIOGRAPHY; CORONARY VASOSPASM; CORONARY VESSELS; ETHANOL; FEMALE; FLUSHING; GENOTYPE; HUMANS; INJECTIONS, INTRA-ARTERIAL; JAPAN; LIPID PEROXIDATION; MALE; MIDDLE AGED; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMOKING; URIC ACID;

EID: 84936078656     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.114.013120     Document Type: Article

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