Alcohol flushing and positive ethanol patch test in patients with coronary spastic angina: Possible role of aldehyde dehydrogenase 2 polymorphisms

Internal Medicine

Volumn 52, Issue 23, 2013, Pages 2593-2598

  Mizuno, Yuji ^a   Morita, Sumio ^a,b   Harada, Eisaku ^a   Shono, Makoto ^a   Morikawa, Yoshinobu ^c   Murohara, Toyoaki ^b   Yasue, Hirofumi ^a  

^a Kumamoto Kinoh Hospital   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Nara City Hospital   (Japan)

Author keywords

Acetaldehyde dehydrogenase 2; Alcohol; Coronary spastic angina; Ethanol patch test; Smoking

Indexed keywords

ACETYLCHOLINE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; GLYCERYL TRINITRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ISOSORBIDE DINITRATE; URIC ACID;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL INTOLERANCE; ANGINA PECTORIS; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CORONARY ARTERY SPASM; CORONARY SPASTIC ANGINA; DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; DNA POLYMORPHISM; DRUG DOSE INCREASE; ETHANOL PATCH TEST; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; QUESTIONNAIRE; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SMOKING;

AGED; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ANGINA PECTORIS; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CORONARY VASOSPASM; ETHANOL; FEMALE; FLUSHING; HUMANS; JAPAN; MALE; MIDDLE AGED; PATCH TESTS; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84888816379     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.52.0894     Document Type: Article

References (26)

1. Yasue H, Nakagawa H, Itoh T, Harada E, Mizuno Y. Coronary artery spasm--clinical features, diagnosis, pathogenesis, and treatment. J Cardiol 51: 2-17, 2008.
2. JCS Joint Working Group. Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina). Circ J 74: 1745-1762, 2010.
3. Pristipino C, Beltrame JF, Finocchiaro ML, et al. Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction. Circulation 101: 1102-1108, 2000.
4. Schukit MA. Ethanol and Methanol. In: Goodman & Gilman's Pharmacological Basis of Therapeutics. 12th Ed. Brunton L, Chabner B, Knollman B, Eds. McGraw Hill, New York, 2011: 629-647.
5. Takeshita T, Yang X, Morimoto K. Association of the ADH2 genotypes with skin responses after ethanol exposure in Japanese male university students. Alcohol Clin Exp Res 25: 1264-1269, 2001.
6. Oota H, Pakstis AJ, Bonne-Tamir B, et al. The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. Ann Hum Genet 68: 93-109, 2004.
7. Li H, Borinskaya S, Yoshimura K, et al. Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. Ann Hum Genet 73: 335-345, 2009.
8. Yokoyama A, Omori T, Yokoyama T. Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians. Keio J Med 59: 115-130, 2010.
9. Takizawa A, Yasue H, Omote S, et al. Variant angina induced by alcohol ingestion. Am Heart J 107: 25-27, 1984.
10. Seki T, Okayama H, Isoyama S, et al. The role of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes in alcoholinduced vasospastic angina. Tohoku J Exp Med 187: 311-322, 1999.
11. Morikawa Y, Mizuno Y, Harada E, Kuboyama O, Yoshimura M, Yasue H. Nitrate tolerance as a possible cause of multidrugresistant coronary artery spasm. Int Heart J 51: 211-213, 2010.
12. Nakagawa T, Kajiwara A, Saruwatari J, et al. The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption. Pharmacogenet Genomics 23: 34-37, 2013.
13. Muramatsu T, Higuchi S, Shigemori K, et al. Ethanol patch test--a simple and sensitive method for identifying ALDH phenotype. Alcohol Clin Exp Res 13: 229-231, 1989.
14. Matsuse H, Shimoda T, Fukushima C, et al. Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test. J Allergy Clin Immunol 108: 715-719, 2001.
15. Okumura K, Yasue H, Horio Y, et al. Multivessel coronary spasm in patients with variant angina: a study with intracoronary injection of acetylcholine. Circulation 77: 535-542, 1988.
16. Makino T, Sinnno K, Yokoi H, Matsui C, Morohasi M. Simple ethanol patch test for alcohol tolerance. J New Rem & Clin 52: 130-135, 2003 (in Japanese).
17. Sueda S, Kohno H, Fukuda H, et al. Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations. Coron Artery Dis 15: 491-497, 2004.
18. Takagi Y, Yasuda S, Takahashi J, et al; Japanese Coronary Spasm Association. Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association. Eur Heart J 34: 258-267, 2013.
19. Goedde HW, Agarwal DP, Harada S. Alcohol metabolizing enzymes: studies of isozymes in human biopsies and cultured fibroblasts. Clin Genet 16: 29-33, 1979.
20. Chen CH, Sun L, Mochly-Rosen D. Mitochondrial aldehyde dehydrogenase and cardiac diseases. Cardiovasc Res 88: 51-57, 2010.
21. Beretta M, Wölkart G, Schernthaner M, et al. Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-2. Circ Res 110: 385-393, 2012.
22. Takagi S, Iwai N, Yamauchi R, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res 25: 677-681, 2002.
23. Takeuchi F, Yokota M, Yamamoto K, et al. Genome-wide association study of coronary artery disease in the Japanese. Eur J Hum Genet 20: 333-340, 2012.
24. Jo SA, Kim EK, Park MH, et al. A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men. Clin Chim Acta 382: 43-47, 2007.
25. Krenz M, Korthuis RJ. Moderate ethanol ingestion and cardiovascular protection: from epidemiologic associations to cellular mechanisms. J Mol Cell Cardiol 52: 93-104, 2012.
26. Xue L, Xu F, Meng L, et al. Acetylation-dependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation. FEBS Lett 586: 137-142, 2012.