ALDH2∗2 but not ADH1B∗2 is a causative variant gene allele for Asian alcohol flushing after a low-dose challenge: Correlation of the pharmacokinetic and pharmacodynamic findings

Pharmacogenetics and Genomics

Volumn 24, Issue 12, 2014, Pages 607-617

  Peng, Giia Sheun ^a   Chen, Yi Chyan ^c   Wang, Ming Fang ^b   Lai, Ching Long ^d   Yin, Shih Jiun ^b  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c TAIPEI TZU CHI HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Alcohol dehydrogenase; alcohol flushing; alcohol sensitivity reaction; alcoholism; aldehyde dehydrogenase; blood ethanol acetaldehyde acetate; causal allelic variant,facial skin blood flow; pulse rate

Indexed keywords

ACETIC ACID; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; ALDEHYDE DEHYDROGENASE ISOENZYME 2; UNCLASSIFIED DRUG; ACETALDEHYDE; ACETIC ACID DERIVATIVE; ADH1B PROTEIN, HUMAN; ALCOHOL; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, HUMAN;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOLISM; ALLELE; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR RESPONSE; EAST ASIAN; GENETIC VARIABILITY; GENOTYPE; HAN CHINESE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; PHARMACODYNAMICS; PRIORITY JOURNAL; PULSE RATE; SKIN BLOOD FLOW; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; DRINKING BEHAVIOR; GENETICS; PATHOPHYSIOLOGY; YOUNG ADULT;

ACETALDEHYDE; ACETATES; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALDEHYDE DEHYDROGENASE; ASIAN CONTINENTAL ANCESTRY GROUP; ETHANOL; HUMANS; MALE; YOUNG ADULT;

EID: 84923847551     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0000000000000096     Document Type: Article

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