Beyond reactive oxygen species: Aldehydes as arbitrators of alarm and adaptation

Circulation Research

Volumn 105, Issue 11, 2009, Pages 1044-1046

  Hill, Bradford G ^a   Bhatnagar, Aruni ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ALDEHYDE; ALDEHYDE DEHYDROGENASE; ALDEHYDE REDUCTASE; ALPHA TOCOPHEROL; ANTIOXIDANT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INITIATION FACTOR 2ALPHA; OXIDIZING AGENT; REACTIVE OXYGEN METABOLITE; UNSATURATED FATTY ACID;

EDITORIAL; GENE EXPRESSION; GENE MUTATION; GLUCOSE METABOLISM; GLUTATHIONE METABOLISM; HEART MUSCLE ISCHEMIA; HEART PROTECTION; LIPID OXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN MODIFICATION; REPERFUSION INJURY; ADAPTATION; ANIMAL; CARDIOVASCULAR DISEASE; HUMAN; METABOLISM; NOTE; PHYSIOLOGY;

ADAPTATION, PHYSIOLOGICAL; ALDEHYDES; ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; REACTIVE OXYGEN SPECIES;

EID: 73349085271     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.209791     Document Type: Editorial

References (7)

1. Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Ogawa S, Fukuda K. Metabolic remodeling induced by mitochondrial aldehyde stress stimulates tolerance to oxidative stress in the heart. Circ Res. 2009;105:1118-1127.
2. Conklin D, Prough R, Bhatanagar A. Aldehyde metabolism in the cardiovascular system. Mol Biosyst. 2007;3:136-150.
3. Shinmura K, Bolli R, Liu SQ, Tang XL, Kodani E, Xuan YT, Srivastava S, Bhatnagar A. Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circ Res. 2002;91:240-246.
4. Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009;105:793-802.
5. Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. Activation of aldehyde dehydrogenase-2 reduces ische-mic damage to the heart. Science. 2008;321:1493-1495.
6. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest. 2005;115:2656-2664.
7. Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mito-chondrial respiration and increasing oxidative stress. Cell Metab. 2007;6:280-293.