Chemical manipulation of the mTORC1 pathway in industrially relevant CHOK1 cells enhances production of therapeutic proteins

Biotechnology Journal

Volumn 10, Issue 7, 2015, Pages 1041-1050

  Dadehbeigi, Nazanin ^a   Dickson, Alan J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

CHOK1; Eukaryotic initiation factor 4E binding protein 1 (4E BP1); MAb production; MTOR Complex 1; Rapamycin

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; CELL GROWTH; CELL SIGNALING; CELLS; CYTOLOGY; GROWTH KINETICS; MAMMALS; MOBILE SECURITY; PHOSPHORYLATION; PRODUCTIVITY; PROTEINS; RECOMBINANT PROTEINS;

BINDING PROTEINS; CHEMICAL MANIPULATION; CHOK1; COMPLEX 1; INTRACELLULAR PATHWAYS; RAPAMYCIN; RECOMBINANT PROTEIN PRODUCTIONS; SPECIFIC PRODUCTIVITY;

MOLECULAR BIOLOGY;

INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MONOCLONAL ANTIBODY; S6 KINASE; S6 KINASE 1; UNCLASSIFIED DRUG; EIF4EBP1 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN; RAPAMYCIN; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL VIABILITY; CHO CELL LINE; CONTROLLED STUDY; FEMALE; GROWTH INHIBITION; INOCULATION; NONHUMAN; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; CHEMISTRY; CRICETULUS; DRUG EFFECTS; GENETICS; HAMSTER; METABOLISM; PHOSPHORYLATION; PROTEIN SYNTHESIS;

EUKARYOTA; MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; METABOLIC NETWORKS AND PATHWAYS; MULTIPROTEIN COMPLEXES; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RECOMBINANT PROTEINS; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84935750834     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500075     Document Type: Article

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