Distinct repression of translation by wortmannin and rapamycin

European Journal of Biochemistry

Volumn 247, Issue 1, 1997, Pages 449-456

  Pedersen, Susanne ^a   Celis, Julio E ^b   Nielsen, Jacob ^c   Christiansen, Jan ^c   Nielsen, Finn C ^a  

^a Rigshospitalet   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

p70(s6k) signaling pathway; Rapamycin; Translation; Wortmannin

Indexed keywords

CELL PROTEIN; DRUG BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; RIBOSOME PROTEIN; TACROLIMUS; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL GROWTH; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

ANIMALIA; EUKARYOTA;

EID: 0030758699     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1997.00449.x     Document Type: Article

References (44)

1. Mathews, M. B., Sonenberg, N. & Hershey, J. W. B. (1996) Origins and targets of translational control, in Translational control (Hershey, J. W. B., Mathews, M. B., Sonenberg, N., eds) pp. 1-29. Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
2. Merrick, W. C. & Hershey, J. W. B. (1996) The pathway and mechanism of eukaryotic protein synthesis, in Translational control (Hershey, J. W. B., Mathews, M. B., Sonenberg, N., eds) pp. 31-69, Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
3. s6k function is essential for G1 progression, Nature 363, 170-172.
4. Jefferies, H. B. J. & Thomas, G. (1995) Ribosomal protein S6 phosphorylation and signal transduction. in Translational control (Hershey, J. W. B., Mathews, M. B., Sonenberg, N., eds) pp. 389-409, Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
5. Brown, E. J., Beal, P. A., Keith, C. T., Chen, J., Shin, T. B. & Schreiber, S. L. (1995) Control of p70 S6 kinase by kinase activity of FRAP in vivo. Nature 377, 441-446.
6. s6k activation mediated by phosphatidylinositol-3-OH kinase, Nature 370, 71-75.
7. Burgering, B. M. T. & Coffer, P. J. (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction, Nature 376, 599-602.
8. Chou, M. M. & Blenis, J. (1996) The 70 kDa S6 kinase complexes with and is activated by the Rho family of G proteins Cdc42 and Rac1, Cell 85, 573-583.
9. Ui, M., Okada, T., Hazeki, K. & Hazeki, O. (1995) Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase, Trends Biochem. Sci. 20, 303-307.
10. Chung, J., Kuo, C. J.. Crabtree, G. R. & Blenis, J. (1992) Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 69, 1227-1236.
11. Price, D. J., Grove, J. R., Calvo, V., Avruch, J. & Blierer, B. E. (1992) Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase, Science 257, 973-977.
12. Choi, J., Chen, J., Schreiber, S. L. & Clardy, J. (1996) Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP, Science 273, 239-242.
13. Jenö, P., Jäggi, N., Luther, H., Siegmann, M. & Thomas, G. (1989) Purification and characterization of a 40 S ribosomal protein S6 kinase from vanadate-stimulated Swiss 3T3 cells, J. Biol. Chem. 264, 1293-1297.
14. de Groot, R. P., Ballou, L. M. & Sassone-Corsi, P. (1994) Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression. Cell 79, 81-91.
15. Pause, A., Belsham, G. J., Gingras, A.-C., Donzé, O., Lin, T.-A., Lawrence, J. C. Jr & Sonenberg, N. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371, 762-767.
16. s6k pathway and is independent of mitogen-activated protein kinase, Proc. Natl Acad. Sci. USA 93, 4076-4080.
17. Beretta, L., Gingras, A. C., Svitkin, Y. V., Hall, M. N. & Sonenberg, N. (1996) Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation, EMBO J. 15, 658-664.
18. Redpath, N. T., Foulstone, E. J. & Proud, C. G. (1996) Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway, EMBO J. 15, 2291-2297.
19. Jefferies, H. B. J., Reinhard, C., Kozma, S. C. & Thomas, G. (1994) Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family, Proc. Nat; Acad. Sci. USA 91, 4441-4445.
20. Terada, N., Patel, H. R., Takase, K., Kohno, K., Nairn, A. C. & Gelfand, E. W. (1994) Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl Acad. Sci. USA 91, 11477-11481.
21. Avni, D., Shama, S., Loreni, F. & Meyuhas, O. (1994) Vertebrate mRNAs with a 5′-terminal pyrimidine tract are candidates for translational repression in quiescent cells: Characterization of the translational cis-regulatory element. Mol. Cell. Biol. 14, 3822-3833.
22. Nielsen, F. C., Østergaard, L., Nielsen, J. & Christiansen, J. (1995) Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway, Nature 377, 358-362.
23. Nielsen, F. C. & Christiansen, J. (1992) Endonucleolysis in the turnover of insulin-like growth factor II mRNA. J. Biol. Chem. 267, 19404-19411.
24. Sambrook, J., Fritsch, E. F. & Maniatis, T (1989) Molecular cloning, a laboratory manual, 2nd edn, Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
25. Sussenbach, J. S. (1989) The gene structure of the insulin-like growth factor family, Progr. Growth Factor Res. 1, 33-48.
26. Celis, J. E., Gesser, B., Rasmussen, H. H., Madsen, P., Leffers, H., Dejgaard, K., Honore, B., Olsen, E., Ratz, G., Lauridsen, J. B., Basse, B., Mouritzen, S., Hellerup, M., Andersen, A., Walbum, E., Cells, A., Bauw, G., Puype, M., van Damme, J. & Vandekerckhove, J. (1990) Comprehensive two-dimensional gel protein data-hases offer a global approach to the analysis of human cells: The transformed amnion cells (AMA) master database and its link to genome DNA sequence data, Electrophoresis 11, 989-1071.
27. Lane, H. A. & Thomas, G. (1991) Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells, Methods Enzymol. 200, 268-291.
28. Tuazon, P. T., Morley, S. J., Dever, T. E., Merrick, W. C., Rhoads, R. E. & Traugh, J. A. (1990) Association of initiation factor eIF-4E in a cap binding protein complex (eIF-4F) is critical for and enhances phosphorylation by protein kinase C, J. Biol. Chem. 265, 10617-10621.
29. Barbel, N. C., Schneider, U., Helliwell, S. B., Stansfield, I., Tuite, M. K & Hall, M. N. (1996) TOR controls translation initiation and early G1 progression in yeast. Mol. Biol. Cell 7, 25-42.
30. Meyuhas, O., Avni, D. & Shama, S. (1996) Translational control of ribosomal protein inRNAs in eukaryotes, in Translational control (Hershey, J. W. B., Mathews, M. B., Sonenberg, N., eds) pp. 363-388, Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
31. Akimoto, K., Takahashi, R., Moriya, S., Nishioka, N., Takayanagi, J., Kimura, K., Fukui, Y., Osada, S., Mizuno, K., Ilirai, S., Kazlauskas, A. & Ohno, S. (1996) EGF or PDGF receptors activate atypical PKCZ through phosphatidylinositol 3-kinase, EMBO J. 15, 788-798.
32. Lodish, H. F. (1974) Model for the regulation of mRNA translation applied to haemoglobin synthesis, Nature 251, 385-388.
33. Rouault, T., Klausner, R. D. & Harford, J. (1996) Translation control of ferritin, in Translational control (Hershey, J. W. B., Mathews, M. B., Sonenberg, N., eds) pp. 335-362, Cold Spring Harbor Laboratory, Cold Spring Harbor NY.
34. Rau, M., Ohlmann, T., Morley, S. J. & Pain, V. M. (1996) A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate, J. Biol. Chem. 271, 8983-8990.
35. Mendez, R., Myers, M. G., White, M. F. & Rhoads, R. E. (1996) Stimulation of protein synthesis, eukaryotic initiation factor 4E phosphorylation, and PHAS-I phosphorylalion by insulin requires insulin receptor substrate 1 and phosphatidy linositol 3-kinase, Mol. Cell Biol. 16, 2857-2864.
36. Stone, E. M., Rothblum, K. N., Alevy, M. C., Kuo, T. M. & Schwartz, R. J. (1985) Complete sequence of the chicken glyceraldehyde-3-phosphate dehydrogenase gene, Proc. Natl Acad. Sci. USA 82, 1628-1632.
37. Ercolani, L., Florence, B., Denaro, M. & Alexander, M. (1988) Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase gene, J. Biol. Chem. 263, 15335-15341.
38. Biamonti, G., Buvoli, M., Bassi, M. T. Morandi, C., Cobiachi, F. & Riva, S. (1989) Isolation of an active gene encoding human hnRNP protein A1. Evidence for alternative splicing, J. Mol. Biol. 207, 491-503.
39. Kato, S., Sekine, S., Oh, S. W., Kim, N. S., Umezawa, Y., Abe, N., Yokoyama-Kobayashi, M. & Aoki, T. (1994) Construction of a human full-length cDNA bank, Gene 150, 243-250.
40. Kozu, T., Henrich, B. & Schafer, K. P. (1995) Structure and expression of the gene (HNRP A2B1) encoding the human hnRNP protein A2/B1, Genomics 25, 365-371.
41. Singer-Sam, J., Keith, D. H., Tani, K., Simmer, R. L., Shively, L., Lindsay, S., Yoshida, A. & Riggs, A. D. (1984) Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase, Gene 32, 409-417.
42. Takenaka, M., Noguchi, T., Sadahiro, S., Hirai, H., Yamada, K., Matsuda, T. Imai, H. & Tanaka, T. (1991) Isolation and characterization of the human pyruvate kinase M gene. Eur. J. Biochem. 198, 101-106.
43. Pata, I., Hoth, S., Kruppa, J. & Metspalu, A. (1992) The human ribosomal protein S6 gene: isolation, primary structure and location in chromosome 9, Gene 121, 387-392.
44. Chen, I. T. & Roufa, D. J. (1988) The transcriptionally active human ribosomal protein S17 gene, Gene 70, 107-116.