Highly Enantioselective Michael Addition of Nitroalkanes to Enones and Its Application in Syntheses of (R)-Baclofen and (R)-Phenibut

Synthesis (Germany)

Volumn 47, Issue 14, 2015, Pages 2063-2072

  Guo, Xing Tao ^a   Shen, Jie ^a   Sha, Feng ^a   Wu, Xin Yan ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

chiral primary amine thiourea; dehydroabietic amine; enantioselective Michael addition; nitroalkanes; unsaturated ketones

Indexed keywords

ADDITION REACTIONS; KETONES; PARAFFINS; THIOUREAS;

ASYMMETRIC SYNTHESIS; ENANTIOSELECTIVE MICHAEL ADDITION; HIGH YIELD; ITS APPLICATIONS; NITROALKANES; PRIMARY AMINES; THIOUREA CATALYSTS; UNSATURATED KETONES;

ENANTIOSELECTIVITY;

2 METHYL 6 NITRO 5 PHENYLHEXAN 3 ONE; 3 (NITROMETHYL)CYCLOHEXANONE; 4 (2 CHLOROPHENYL) 5 NITROPENTAN 2 ONE; 4 (2 FURYL) 5 NITROPENTAN 2 ONE; 4 (3 CHLOROPHENYL) 5 NITROPENTAN 2 ONE; 4 (4 BROMOPHENYL) 5 METHYL 5 NITROHEXAN 2 ONE; 4 (4 BROMOPHENYL) 5 NITROPENTAN 2 ONE; 4 (4 CHLOROPHENYL) 5 METHYL 5 NITROHEXAN 2 ONE; 4 (4 CHLOROPHENYL) 5 NITROPENTAN 2 ONE; 4 (4 FLUOROPHENYL) 5 METHYL 5 NITROHEXAN 2 ONE; 4 (4 FLUOROPHENYL) 5 NITROPENTAN 2 ONE; 4 (4 METHOXYPHENYL) 5 NITROPENTAN 2 ONE; 4 (NITROMETHYL) 6 PHENYLHEXAN 2 ONE; 4 (NITROMETHYL)NONAN 2 ONE; 4 AMINO 3 PHENYLBUTYRIC ACID; 4 NITRO 1,3 DIPHENYLBUTAN 1 ONE; 5 (4 CHLOROPHENYL) 2 METHYL 6 NITROHEXAN 3 ONE; 5 METHYL 5 NITRO 4 PHENYLHEXAN 2 ONE; 5 NITRO 4 (4 NITROPHENYL)PENTAN 2 ONE; 5 NITRO 4 (4 TOLYL)PENTAN 2 ONE; 5 NITRO 4 PHENYLHEXAN 2 ONE; 5 NITRO 4 PHENYLPENTAN 2 ONE; 6 NITRO 5 PHENYLHEXAN 3 ONE; BACLOFEN; BACLOFEN[4 AMINO 3 (4 CHLOROPHENYL)BUTANOIC ACID]; KETONE DERIVATIVE; NITROALKANE; PHENIBUT[4 AMINO 3 PHENYLBUTANOIC ACID]; THIOUREA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CHIRALITY; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG OXIDATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; MICHAEL ADDITION; PROCESS OPTIMIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; REACTION TIME;

EID: 84935716929     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0034-1380203     Document Type: Article

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