Catalytic enantioselective conjugate addition of nitromethane to α′-hydroxy enones as surrogates of α,β-unsaturated carboxylic acids and aldehydes

Advanced Synthesis and Catalysis

Volumn 348, Issue 10-11, 2006, Pages 1161-1164

  Palomo, Claudio ^a   Pazos, Raquel ^a   Oiarbide, Mikel ^a   García, Jesús M ^b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b PUBLIC UNIVERSITY OF NAVARRE   (Spain)

Author keywords

Conjugate addition; Enantioselective; Hydroxy ketones; Michael reaction; Nitromethane

Indexed keywords

EID: 33746774321     PISSN: 16154150     EISSN: 15213897     Source Type: Journal    
DOI: 10.1002/adsc.200606076     Document Type: Article

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39. The configuration of adducts 12a and 12h was deduced from comparison with published data (see the Supporting Information for details). Assignments for the remaining adducts were made by analogy. Scission of adducts 11 is equally effective under the above conditions, giving rise to the same compounds 12 and 13 along with cyclohexanone.