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Enone 6 was selected for optimization of the reaction conditions as masked ketone functionality at the 4th position was visualized as an additional handle for the synthesis of highly substituted cyclohexanone moiety CCDC- contains the supplementary crystallographic data for this paper Computational studies for better understanding of the transition state to justify the observed relative trans stereochemical outcome is planned in future
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At this moment, we are not very sure on the exact role of the base in DKR, however, from the studies mentioned above it is clear that changing base affects diastereoselectivity as well as enantioselectivity. It may be possible that malonate and base forms contact ion pair which participates in the addition reaction affecting diastereoselectivity and enantioselectivity (see
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