One-pot enantioselective synthesis of functionalized pyranocoumarins and 2-amino-4 H -chromenes: Discovery of a type of potent antibacterial agent

Journal of Organic Chemistry

Volumn 77, Issue 2, 2012, Pages 878-888

  Zhang, Gen ^a   Zhang, Yaohu ^a   Yan, Jiexi ^a   Chen, Ru ^a   Wang, Shoulei ^a   Ma, Yunxia ^a   Wang, Rui ^a,b  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTIBACTERIAL AGENT; BIOLOGICAL STUDIES; CHROMENES; EFFICIENT PROCESS; ENANTIOSELECTIVE SYNTHESIS; FUNCTIONALIZED; HETEROCYCLIC COMPOUND; HUMAN PATHOGENS; NOVEL STRATEGIES; ONE POT; OPTICALLY ACTIVE; ORGANIC CHEMISTRY; ORGANOCATALYTIC; RESEARCH AND DEVELOPMENT; SMALL MOLECULES;

STEREOCHEMISTRY;

SYNTHESIS (CHEMICAL);

2 AMINO 4 (2 BROMOPHENYL) 5 OXO 4,5 DIHYDROPYRANO [3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (2 FLUOROPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (3 BROMOPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (3 CHLOROPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (3 CHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (3 METHOXYPHENYL ) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 BROMOPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 BROMOPHENYL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 CHLOROPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 CHLOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 CYANOPHENYL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 FLUOROPHENYL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 FLUOROPHENYL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (4 METHOXYPHENYL) 5 OXO 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 4 (FURAN 2 YL) 5 OXO 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 4H CHROMENE DERIVATIVE; 2 AMINO 5 OXO 4 (THIOPHEN 3 YL) 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4 2 TOLYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4 HEXYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 5 OXO 4 PHENYL 5,6,7,8 TETRAHYDRO 4H CHROMENE 3 CARBONITRILE; 2 AMINO 7 METHYL 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[4,3 B]PYRAN 3 CARBONITRILE; 2 AMINO 9 CHLORO 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 9 METHOXY 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; 2 AMINO 9 METHYL 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBONITRILE; ANTIINFECTIVE AGENT; ETHYL 2 AMINO 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBOXYLATE; METHYL 2 AMINO 5 OXO 4 PHENYL 4,5 DIHYDROPYRANO[3,2 C]CHROMENE 3 CARBOXYLATE; PYRANOCOUMARIN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ERYTHROCYTE; ESCHERICHIA COLI; HUMAN; HUMAN CELL; KNOEVENAGEL CONDENSATION; MICHAEL ADDITION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; ONE POT SYNTHESIS; STAPHYLOCOCCUS AUREUS;

AMINES; ANIMALS; ANTI-BACTERIAL AGENTS; BENZOPYRANS; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIZATION; DRUG EVALUATION, PRECLINICAL; ERYTHROCYTES; ESCHERICHIA COLI; HELA CELLS; HUMANS; JURKAT CELLS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRANOCOUMARINS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS, CHRONIC;

EID: 84862908851     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo202020m     Document Type: Article

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