Enantioselective carbon-hydrogen insertion is an effective and efficient methodology for the synthesis of (R)-(-)-baclofen

Chirality

Volumn 14, Issue 2-3, 2002, Pages 169-172

  Doyle, Michael P ^a   Hu, Wenhao ^a  

^a University of Arizona   (United States)

Author keywords

Catalytic enantioselective synthesis; Chiral dirhodium(II) carboxamidates; Diazoacetate; Metal carbene reactions

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN;

ARTICLE; CHIRALITY; DRUG SYNTHESIS; MOLECULAR INTERACTION; PRIORITY JOURNAL; UNITED STATES;

BACLOFEN; CARBON; CATALYSIS; HYDROGEN; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM;

EID: 0036151961     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/chir.10060     Document Type: Article

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1. B receptor studies
2. B receptor agonist, more active peripherally
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6. A chemoenzymatic strategy for the synthesis of enantiopure (R)-(-)-baclofen
7. Enantioselective synthesis of β-substituted butyric acid derivatives via orthoester Claisen rearrangement of enzymatically resolved allylic alcohols: Application to the synthesis of (R)-(-)-baclofen
8. A practical synthesis of (2S, 3R)-3-amino-2-methylpentanoic acid from L-aspartic acid
9. Enantioselective synthesis of (R)-(-)-baclofen using Fischer-type carbene anions
10. 3 complexes of ethyl cinnamate derivatives: Stereoselective synthesis of (R)-(-)-baclofen
11. Recent advances in asymmetric catalytic metal carbene transformations
12. Intramolecular regioselective insertion into unactivated prochiral carbon-hydrogen bonds with diazoacetates catalyzed by chiral dirhodium(II) carboxamidates
13. Asymmetric synthesis of lactones with high enantios-electivity by intramolecular carbon-hydrogen insertion reactions of alkyl diazoacetates catalyzed by chiral rhodium(II) carboxamidates
14. Reactions of sodium phenylacetylide and sodium alkoxide with tosyl and mesyl azides
15. Enantioselective synthesis of 4-substituted 2-pyrrolidinones by site-selective C-H insertion of α-methoxycarbonyl-α-diazoacetanilides catalyzed by dirhodium(II) tetrakis [N-phtaloyl-(S)-tert-leucinate]