A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages E3619-E3628

  Napolitano, Luisa Maria Rosaria ^a   Bisha, Ina ^b   De March, Matteo ^a   Marchesi, Arin ^b   Arcangeletti, Manuel ^b   Demitri, Nicola ^a   Mazzolini, Monica ^b   Rodriguez, Alex ^b   Magistrato, Alessandra ^b,c   Onesti, Silvia ^a   Laio, Alessandro ^b   Torre, Vincent ^b  

^a SINCROTRONE TRIESTE   (Italy)

^b SISSA   (Italy)

^c IOM CNR LABORATORIO TASC   (Italy)

Author keywords

CNG channels; MD simulations; Pore flexibility; X ray crystallography

Indexed keywords

CALCIUM CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL; MONOVALENT CATION; PROLINE; SODIUM CHANNEL; BACTERIAL PROTEIN; CESIUM; CNGA1 PROTEIN, BOVINE; MUTANT PROTEIN; SODIUM;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; HYDROGEN BOND; ION CONDUCTANCE; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; BOVINE; CHANNEL GATING; CHEMISTRY; DRUG EFFECTS; FEMALE; GENETICS; ION TRANSPORT; MEMBRANE POTENTIAL; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; OOCYTE; PATCH CLAMP TECHNIQUE; PHYSIOLOGY; SEQUENCE HOMOLOGY; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; CATIONS, MONOVALENT; CATTLE; CESIUM; CRYSTALLOGRAPHY, X-RAY; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; FEMALE; ION CHANNEL GATING; ION TRANSPORT; MEMBRANE POTENTIALS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION, MISSENSE; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM; XENOPUS LAEVIS;

EID: 84935506497     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503334112     Document Type: Article

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