Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 2, 2011, Pages 598-602

  Derebe, Mehabaw G ^a   Sauer, David B ^a   Zeng, Weizhong ^a,b   Alam, Amer ^c   Shia, Ning ^a,b   Jiang, Youxing ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c ETH ZURICH   (Switzerland)

Author keywords

Nonselective cation channel; Potassium channel

Indexed keywords

CYCLIC NUCLEOTIDE GATED CHANNEL; POTASSIUM CHANNEL; SODIUM CHANNEL;

ARTICLE; BACILLUS CEREUS; BINDING SITE; ELECTROPHYSIOLOGY; GEOMETRY; ION SELECTIVE ELECTRODE; ION TRANSPORT; NONHUMAN; PRIORITY JOURNAL;

BACILLUS SUBTILIS; BINDING SITES; CARBON; CRYSTALLOGRAPHY, X-RAY; ELECTROPHYSIOLOGY; IONS; LIGANDS; MUTATION; OXYGEN; POTASSIUM; POTASSIUM CHANNELS; PROTEIN BINDING; PROTEIN CONFORMATION; SODIUM;

EID: 79551660280     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1013636108     Document Type: Article

References (32)

1. + conduction and selectivity. Science 280:69-77.
2. + channel-Fab complex at 2.0 A resolution. Nature 414:43-48.
3. Nishida M, Cadene M, Chait BT, MacKinnon R (2007) Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J 26:4005-4015.
4. + channel locked in the conductive conformation. Science 314:1004-1007.
5. + channel in a lipid membrane-like environment. Nature 450:376-382.
6. + channel Kir2.2 at 3.1 A resolution. Science 326:1668-1674.
7. Alam A, Jiang Y (2009) Structural analysis of ion selectivity in the NaK channel. Nat Struct Mol Biol 16:35-41.
8. + conducting channel. Nature 440:570-574.
9. + channel signature sequence. Biophys J 66:1061-1067.
10. + channels. Science 258:1152-1155.
11. Bezanilla F, Armstrong CM (1972) Negative conductance caused by entry of sodium and cesium ions into the potassium channels of squid axons. J Gen Physiol 60:588-608.
12. Mullins LJ (1960) An analysis of pore size in excitable membranes. J Gen Physiol 43:105-117.
13. Noskov SY, Berneche S, Roux B (2004) Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands. Nature 431:830-834.
14. Noskov SY, Roux B (2007) Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels. J Gen Physiol 129:135-143.
15. + channels is due to topological control of the permeant ion's coordinated state. Proc Natl Acad Sci USA 104:9260-9265.
16. Thomas M, Jayatilaka D, Corry B (2007) The predominant role of coordination number in potassium channel selectivity. Biophys J 93:2635-2643. (Pubitemid 47607801)
17. + selectivity in K channels and valinomycin: Over-coordination versus cavity-size constraints. J Mol Biol 376:13-22.
18. Varma S, Rempe SB (2007) Tuning ion coordination architectures to enable selective partitioning. Biophys J 93:1093-1099.
19. + selectivity in potassium channels. J Am Chem Soc 131:8092-8101.
20. Egwolf B, Roux B (2010) Ion selectivity of the KcsA channel: A perspective from multi-ion free energy landscapes. J Mol Biol 401:831-842.
21. Thompson AN, et al. (2009) Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nat Struct Mol Biol 16:1317-1324.
22. Yau KW, Baylor DA (1989) Cyclic GMP-activated conductance of retinal photoreceptor cells. Annu Rev Neurosci 12:289-327.
23. Kaupp UB, Seifert R (2002) Cyclic nucleotide-gated ion channels. Physiol Rev 82:769-824.
24. Zagotta WN, Siegelbaum SA (1996) Structure and function of cyclic nucleotide-gated channels. Annu Rev Neurosci 19:235-263.
25. Finn JT, Grunwald ME, Yau KW (1996) Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu Rev Physiol 58:395-426. (Pubitemid 26106727)
26. + channel pore. Nat Struct Mol Biol 17:1019-1023.
27. Starkus JG, Kuschel L, Rayner MD, Heinemann SH (1997) Ion conduction through C-type inactivated Shaker channels. J Gen Physiol 110:539-550.
28. + affinity of an ion binding site revealing ion-ion interactions in the pore. J Gen Physiol 112:243-257.
29. Alam A, Jiang Y (2009) High-resolution structure of the open NaK channel. Nat Struct Mol Biol 16:30-34.
30. 2+ specificity in tetrameric cation channels. Proc Natl Acad Sci USA 104:15334-15339.
31. Heginbotham L, LeMasurier M, Kolmakova-Partensky L, Miller C (1999) Single streptomyces lividans K(+) channels: Functional asymmetries and sidedness of proton activation. J Gen Physiol 114:551-560.
32. + channel with and without the gating ring. J Gen Physiol 129:109-120.