Minocycline Protects Against NLRP3 Inflammasome-Induced Inflammation and P53-Associated Apoptosis in Early Brain Injury After Subarachnoid Hemorrhage

Molecular Neurobiology

Volumn 53, Issue 4, 2016, Pages 2668-2678

  Li, Jianru ^a   Chen, Jingsen ^a   Mo, Hangbo ^a   Chen, Jingyin ^a   Qian, Cong ^a   Yan, Feng ^a   Gu, Chi ^a   Hu, Qiang ^b   Wang, Lin ^a   Chen, Gao ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Early brain injury; Minocycline; NLRP3; P53; Subarachnoid hemorrhage

Indexed keywords

CASPASE 3; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; MINOCYCLINE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; NEUROPROTECTIVE AGENT; NLRP3 PROTEIN, RAT; PROTEIN P53; TRANSCRIPTION FACTOR RELA; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER DYSFUNCTION; BLOOD BRAIN BARRIER PERMEABILITY; BRAIN CORTEX; BRAIN DYSFUNCTION; BRAIN EDEMA; BRAIN FUNCTION; BRAIN INJURY; BRAIN PROTECTION; BRAIN WATER; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; EARLY BRAIN INJURY; IBA 1 CELL; INFLAMMATION; LEFT HEMISPHERE; MALE; MICROGLIA; MORTALITY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; SCORING SYSTEM; SUBARACHNOID HEMORRHAGE; TUNEL ASSAY; ANIMAL; BRAIN INJURIES; CELL NUCLEUS; COMPLICATION; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; CELL NUCLEUS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MICROGLIA; MINOCYCLINE; NEUROPROTECTIVE AGENTS; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SUBARACHNOID HEMORRHAGE; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEIN P53; WATER;

EID: 84935131224     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9318-8     Document Type: Article

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