A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites

Chemico-Biological Interactions

Volumn 238, Issue , 2015, Pages 102-110

  Campbell, Jerry ^a   Van Landingham, Cynthia ^b   Crowell, Susan ^c   Gentry, Robinan ^b   Kaden, Debra ^b   Fiebelkorn, Stacy ^d   Loccisano, Anne ^e   Clewell, Harvey ^a,b  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b ENVIRON INTERNATIONAL CORPORATION   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^d BRITISH AMERICAN TOBACCO   (United Kingdom)

^e R J REYNOLDS TOBACCO COMPANY   (United States)

Author keywords

1,3 Butadiene; Lung metabolism; PBPK; Physiologically based pharmacokinetic model

Indexed keywords

1,3 BUTADIENE; BIOLOGICAL MARKER; 1,3 BUTADIENE DERIVATIVE; 1,3-BUTADIENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MODEL; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG METABOLISM; HUMAN; IN VITRO STUDY; KIDNEY METABOLISM; LIVER METABOLISM; LUNG; MOUSE; NONHUMAN; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL; RAT; RISK ASSESSMENT; TOXICOKINETICS; ANIMAL; HALF LIFE TIME; KIDNEY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALIA; NICOTIANA TABACUM; RATTUS;

ANIMALS; BUTADIENES; HALF-LIFE; HUMANS; KIDNEY; LUNG; MICE; MODELS, BIOLOGICAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84934999855     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.05.025     Document Type: Article

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