A physiological toxicokinetic model for 1,3-butadiene in rodents and man: Blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts - Relevance of glutathione depletion

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 300-305

  Csanady Gy A ^a,c   Kreuzer, P E ^a   Baur, C ^b   Filser, J G ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b Inst fur Gerichtsmedizin der L   (Germany)

^c CTRL RES INSTITUTE FOR CHEMISTRY   (Hungary)

Author keywords

1,2 epoxy 3 butene; 1,2:3,4 diepoxybutane; 1,3 butadiene; glutathione; hae moglobin adducts; humans; mice; physiological toxicokinetic model; rats; toxicokinetics

Indexed keywords

1,3 BUTADIENE; BUTADIENE DIEPOXIDE; EPOXIDE; GLUTATHIONE; HEMOGLOBIN;

ANIMAL EXPERIMENT; BLOOD LEVEL; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; HYDROLYSIS; MALE; METABOLITE; MODEL; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN BINDING; RAT; TOXICOKINETICS; XENOBIOTIC METABOLISM;

ANIMALIA; RODENTIA;

EID: 0030605039     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03461-0     Document Type: Conference Paper

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