Physiologically based pharmacokinetic modeling of blood and tissue epoxide measurements for butadiene

Toxicology

Volumn 113, Issue 1-3, 1996, Pages 318-321

  Sweeney, Lisa M ^b   Himmelstein, Matthew W ^a,b   Schlosser, Paul M ^b   Medinsky, Michele A ^b  

^a DUPONT COMPANY   (United States)

^b CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

butadiene; dosimetry; epoxides; physiologically based pharmacokinetic model

Indexed keywords

1,3 BUTADIENE; EPOXIDE; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BIOTRANSFORMATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSIMETRY; INHALATION; MODEL; MOUSE; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE; TISSUE LEVEL; TOXICOKINETICS;

ANIMALIA; RODENTIA;

EID: 0011917872     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(96)03465-8     Document Type: Conference Paper

References (7)

1. Csanády, G.A., Guengerich, F.P. and Bond, J.A. (1992) Comparison of the biotransformation of 1.3 butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis 13, 1143-1153.
2. D'Souza, R.W., Francis, W.R. and Andersen, M.E. (1988) Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure. J. Pharmacol. Exp. Ther. 245, 563-568.
3. Himmelstein, M.W., Asgharian, B. and Bond, J.A. (1995) High concentrations of butadiene epoxides in livers and lungs of mice compared to rats exposed to 1,3-butadiene. Toxicol. Appl. Pharmacol. 132, 281-288.
4. Himmelstein, M.W., Turner, M.J., Asgharian, B. and Bond, J.A. (1994) Comparison of blood concentrations of 1,3-butadiene and butadiene epoxides in mice and rats exposed to 1,3-butadiene by inhalation. Carcinogenesis 15, 1479-1486.
5. International Life Sciences Institute (ILSI) (1994) Physiological Parameter Values for PBPK Models.
6. Kreiling, R., Laib, R.J., Filser, J.G. and Bolt, H.M. (1987) Inhalation pharmacokinetics of 1,2-epoxybutene-3 reveal species differences between rats and mice sensitive to butadiene-induced carcinogenesis. Arch. Toxicol. 61, 7-11.
7. Medinsky, M.A., Leavens, T.L., Csanády, G.A., Gargas, M.L. and Bond, J.A. (1994) In vivo metabolism of butadiene by mice and rats: a comparison of physiological model predictions and experimental data. Carcinogenesis 15, 1329-1340.