Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene

Toxicological Sciences

Volumn 55, Issue 2, 2000, Pages 266-273

  Jackson, T E ^a,b   Lilly, P D ^a,c   Recio, L ^a   Schlosser, P M ^a   Medinsky, M A ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

1,3 butadiene; CYP2E1; Gas uptake; Genotoxicity; Micronuclei

Indexed keywords

1 AMINOBENZOTRIAZOLE; 1,2 DICHLOROETHYLENE; 1,3 BUTADIENE; CARCINOGEN; CYTOCHROME P450 2E1; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROID CELL; GENOTOXICITY; INHALATION; MALE; MICRONUCLEUS; MOUSE; NONHUMAN; OXIDATION;

ANIMALIA; RODENTIA;

EID: 0034041362     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/55.2.266     Document Type: Article

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