Kinetic modeling of β-chloroprene metabolism: I. In vitro rates in liver and lung tissue fractions from mice, rats, hamsters, and humans

Toxicological Sciences

Volumn 79, Issue 1, 2004, Pages 18-27

  Himmelstein, Matthew W ^a   Carpenter, Steven C ^a   Hinderliter, Paul M ^a  

^a DUPONT COMPANY   (United States)

Author keywords

2 chloro 1,3 butadiene; Cytosol; Hamster; Human; In vitro kinetics; Liver; Lung; Microsomes; Mouse; Rat

Indexed keywords

CARCINOGEN; CHLOROPRENE; CYTOCHROME P450; EPOXIDE; EPOXIDE HYDROLASE; GLUTATHIONE TRANSFERASE;

ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; COMPARTMENT MODEL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; EXPOSURE; GENOTOXICITY; HUMAN; HUMAN TISSUE; HYDROLYSIS; IN VITRO STUDY; LIVER MICROSOME; LUNG PARENCHYMA; METABOLISM; MOUSE; MOUSE STRAIN; NONHUMAN; OXIDATION; RAT; RAT STRAIN; RODENT; SPECIES DIFFERENCE; SYRIAN HAMSTER; TOXICOKINETICS;

ANIMALS; CHLOROPRENE; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; EPOXIDE HYDROLASES; ETHYLENE OXIDE; GLUTATHIONE TRANSFERASE; HUMANS; HYDROLYSIS; KINETICS; LIVER; LUNG; MALE; MESOCRICETUS; MICE; MICE, INBRED STRAINS; MICROSOMES, LIVER; MODELS, BIOLOGICAL; OXIDATION-REDUCTION; RATS; RATS, INBRED F344; RATS, WISTAR; SPECIES SPECIFICITY; SUBCELLULAR FRACTIONS; TIME FACTORS;

CRICETINAE; MESOCRICETUS AURATUS; RATTUS NORVEGICUS; RODENTIA;

EID: 2442700338     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh092     Document Type: Article

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