Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 3, 2009, Pages 534-544

  Abulafia, Denise P ^a   De Rivero Vaccari, Juan Pablo ^a   Lozano, J Diego ^a   Lotocki, George ^a   Keane, Robert W ^a   Dietrich, W Dalton ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Focal ischemia; Inflammasome; Inflammation; Interleukins; Stroke

Indexed keywords

INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NEUTRALIZING ANTIBODY; NUCLEOTIDE BINDING PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CAROTID ARTERY THROMBOSIS; CEREBROVASCULAR ACCIDENT; CONFOCAL MICROSCOPY; DOWNSTREAM PROCESSING; GEL PERMEATION CHROMATOGRAPHY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGE; MALE; MICROGLIA; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOEMBOLISM; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS REGULATORY PROTEINS; CAROTID ARTERY THROMBOSIS; CASPASE 1; ENCEPHALITIS; IMMUNOPRECIPITATION; INTERLEUKIN-18; INTERLEUKIN-1BETA; MALE; MICE; MICE, INBRED STRAINS; STROKE; THROMBOEMBOLISM;

EID: 61349152312     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.143     Document Type: Article

References (42)

1. Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319-25
2. Allan SM, Rothwell NJ (2001) Cytokines and acute neurodegeneration. Nat Rev Neurosci 2:734-44
3. Albers GW, Thijs VN, Wechsler L, Kemp S, Schlaug G, Skalabrin E, Bammer R, Kakuda W, Lansberg MG, Shuaib A, Coplin W, Hamilton S, Moseley M, Marks MP, DEFUSE Investigators (2006) Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 60:508-17
4. Butcher KS, Parsons M, MacGregor L, Barber PA, Chalk J, Bladin C, Levi C, Kimber T, Schultz D, Fink J, Tress B, Donnan G, Davis S, EPITHET Investigators (2005) Refining the perfusion-diffusion mismatch hypothesis. Stroke 36:1153-9
5. Danton GH, Dietrich WD (2003) Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 2:127-36
6. Danton GH, Dietrich WD (2004) The search for neuroprotective strategies in stroke. AJNR Am J Neuroradiol 25:181-94
7. de Rivero Vaccari JP, Lotocki G, Marcillo AE, Dietrich WD, Keane RW (2008) A molecular platform in neurons regulates inflammation after spinal cord injury. J Neurosci 23:3404-14
8. del Zoppo G, Ginis I, Hallenbeck JM, Ladecola C, Wang X, Feuerstein GZ (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10:95-112
9. Dietrich WD, Danton G, Hopkins AC, Prado R (1999) Thromboembolic events predispose the brain to widespread cerebral infarction after delayed transient global ischemia in rats. Stroke 30:855-62
10. Dietrich WD, Prado R, Watson BD, Busto R, Ginsberg MD (1991) Hemodynamic consequences of common carotid artery thrombosis and thrombogenically activated blood in rats. J Cereb Blood Flow Metab 11:957-65
11. Dietrich WD, Prado R, Halley M, Watson BD (1993) Microvascular and neuronal consequences of common carotid artery thrombosis and platelet embolization in rats. J Neuropathol Exp Neurol 52:351-60
12. Dinarello CA (2005) Blocking IL-1 in systemic inflammation. J Exp Med 201:1355-9
13. Emsley HC, Smith CJ, Georgiou RF, Vail A, Hopkins SJ, Rothwell NJ, Tyrrell PJ, Acute Stroke Investigators (2005) A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J Neurol Neurosurg Psychiatry 76:1366-72
14. Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly-Maitre B, Volkmann N, Hanein D, Rouiller I, Reed JC (2007) Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 25:713-24
15. Gladstone DJ, Black SE, Hakim AM, Heart and Stroke Foundation of Ontario Centre of Excellence in Stroke Recovery (2002) Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33:2123-36
16. Goussev AV, Zhang Z, Anderson DC, Chopp M (1998) P-selectin antibody reduces hemorrhage and infarct volume resulting from MCA occlusion in the rat. J Neurol Sci 161:16-22
17. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC, Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler RJ, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S (2004) Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS and NINDS rt-PA stroke trials. Lancet 363:768-74
18. Hedtjarn M, Leverin AL, Eriksson K, Blomgren K, Mallard C, Hagberg H (2002) Interleukin-18 involvement in hypoxic-ischemic brain injury. J Neurosci 22:5910-9
19. Keane RW, Kraydieh S, Lotocki G, Alonso OF, Aldana P, Dietrich WD (2001) Apoptotic and antiapoptotic mechanisms after traumatic brain injury. J Cereb Blood Flow Metab 21:1189-98
20. Kummer JA, Broekhuizen R, Everett H, Agostini L, Kuijk L, Martinon F, van Bruggen R, Tschopp J (2007) Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 55:443-52
21. Legos JJ, Tuma RF, Barone FC (2002) Pharmacological interventions for stroke: failures and future. Expert Opin Investig Drugs 11:603-14
22. Loddick SA, Wong ML, Bongiorno PB, Gold PW, Licinio J, Rothwell NJ (1997) Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem Biophys Res Commun 234:211-5
23. Lozano JD, Abulafia DP, Danton GH, Watson BD, Dietrich WD (2007) Characterization of a thromboembolic photochemical model of repeated stroke in mice. J Neurosci Methods 162:244-54
24. Lucas SM, Rothwell NJ, Gibson RM (2006) The role of inflammation in CNS injury and disease. Br J Pharmacol 147(Suppl 1):S232-40
25. Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40
26. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-26
27. Martinon F, Tschopp J (2004) Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 117:561-74
28. Miao EA, Alpuche-Aranda CM, Dors M, Clark AE, Bader MW, Miller SI, Aderem A (2006) Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat Immunol 7:569-75
29. Ogura Y, Sutterwala FS, Flavell RA (2006) The inflammasome: first line of the immune response to cell stress. Cell 126:659-62
30. Paxinos G, Watson C (2005) The rat brain in stereotaxic coordinates. New York, NY: Elsevier
31. Pétrilli V, Papin S, Dostert C, Mayor A, Martinon F, Tschopp J (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14:1583-9
32. Rabuffetti M, Sciorati C, Tarozzo G, Clementi E, Manfredi AA, Beltramo M (2000) Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. J Neurosci 20:4398-404
33. Rothwell N (2003) Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential. Brain Behav Immun 17:152-7
34. Rothwell NJ, Luheshi GN (2000) Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci 23:618-25
35. Tan KT, Lip GY, Blann AD (2003) Post-stroke inflammatory response: effects of stroke evolution and outcome. Curr Atheroscler Rep 5:245-51
36. Thery C, Mallat M (1993) Influence of interleukin-1 and tumor necrosis factor alpha on the growth of microglia l cells in primary cultures of mouse cerebral cortex: involvement of colony-stimulating factor 1. Neurosci Lett 150:195-9
37. Thijs VN, Adami A, Neumann-Haefelin T, Moseley ME, Marks MP, Albers GW (2001) Relationship between severity of MR perfusion deficit and DWI lesion evolution. Neurology 57:1205-11
38. Ting JP, Willingham SB, Bergstralh DT. (2008) NLRs at the intersection of cell death and immunity. Nat Rev Immunol 8:372-9, e-pub ahead of print
39. Trendelenburg G (2008) Acute neurodegeneration and the inflammasome: central processor for danger signals and the inflammatory response? J Cereb Blood Flow Metab 28:867-81
40. Tschopp J, Martinon F, Burns K (2003) NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4:95-104
41. Zhang RL, Chopp M, Jiang N, Tang WX, Prostak J, Manning AM, Anderson DC (1995) Anti-intercellular adhesion molecule-1 antibody reduces ischemic cell damage after transient but not permanent middle cerebral artery occlusion in the Wistar rat. Stroke 26:1438-42
42. Zhang ZG, Zhang L, Ding G, Jiang Q, Zhang RL, Zhang X, Gan WB, Chopp M (2005) A model of mini-embolic stroke offers measurements of the neurovascular unit response in the living mouse. Stroke 36:2701-4