Application of Film-Casting Technique to Investigate Drug-Polymer Miscibility in Solid Dispersion and Hot-Melt Extrudate

Journal of Pharmaceutical Sciences

Volumn 104, Issue 7, 2015, Pages 2142-2152

  Parikh, Tapan ^a,c   Gupta, Simerdeep Singh ^a   Meena, Anuprabha K ^a   Vitez, Imre ^b   Mahajan, Nidhi ^b   Serajuddin, Abu T M ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b CATALENT PHARMA SOLUTIONS   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

amorphous; crystallization; drug polymer miscibility; film casting; hot melt extrusion; itraconazole; polarized light microscopy; polymer; solid dispersion; thermal analysis

Indexed keywords

CELLULOSE; ETHER DERIVATIVE; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; ITRACONAZOLE; POLYMER; POLYMETHACRYLIC ACID; POLYVINYL ACETATE; POVIDONE; EUDRAGIT-E; MACROGOL DERIVATIVE; METHACRYLIC ACID METHYL ESTER; METHYLCELLULOSE; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE;

ARTICLE; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG STABILITY; FILM CASTING TECHNIQUE; HOT MELT EXTRUSION; MISCIBILITY; SOLID; X RAY POWDER DIFFRACTION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG FORMULATION; HEAT; PROCEDURES; SOLUBILITY;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; HOT TEMPERATURE; ITRACONAZOLE; METHYLCELLULOSE; METHYLMETHACRYLATES; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; POVIDONE; SOLUBILITY;

EID: 84934927484     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24446     Document Type: Article

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