Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion - I: Polyvinylpyrrolidone and related polymers

Journal of Excipients and Food Chemicals

Volumn 5, Issue 1, 2014, Pages 32-45

  Gupta, Simerdeep Singh ^a   Meena, Anuprabha ^a   Parikh, Tapan ^a   Serajuddin, Abu T M ^a  

^a ST JOHN'S UNIVERSITY   (United States)

Author keywords

DSC; Hot melt extrusion; Kollidon VA 64; Polyvinylpyrrolidone; PVP; Soluplus ; TGA; Vinyl acetate; Vinyl pyrrolidone; Viscosity

Indexed keywords

POLYMER; POVIDONE;

ARTICLE; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MANUFACTURE; FLOW KINETICS; GLASS TRANSITION TEMPERATURE; HOT MELT EXTRUSION; MOISTURE; MOLECULAR WEIGHT; THERMOGRAVIMETRY; TORQUE; VISCOELASTICITY; X RAY POWDER DIFFRACTION; YOUNG MODULUS;

EID: 84897952521     PISSN: None     EISSN: 21502668     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Williams HD, Trevaskis NL, Charman SA, Shanker RM, Charman WN, Pouton CW, Porter CJ. Strategies to address low drug solubility in discovery and development. Pharmacol Rev, 65(1): 315-499, 2013.
2. Serajuddin ATM. Solid dispersion of poorly water soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci, 88(10): 1058-1066, 1999.
3. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm, 50(1): 47-6, 2000.
4. Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Kumar S, McGinity JW, Martin C. Pharmaceutical application of hot-melt extrusion: Part I. Drug Dev Ind Pharm, 33(9):909-926, 2007.
5. Repka MA, Battu SK, Upadhye SB, Thumma S, Crowley MM, Zhang S, Martin C, McGinity JW. Pharmaceutical application of hot-melt extrusion: Part II. Drug Dev Ind Pharm, 33(10):1043-1047, 2007.
6. Shah S, Maddaneni S, Lu J, Repka MA. Melt extrusion with poorly soluble drugs. Int J Pharm, 453(1):233-52, 2013.
7. Doroumis D. Hot melt extrusion: Pharmaceutical applications. John Wiley & Sons, pp 55, 2012.
8. Hardung H, Djuric D, Ali S. Combining HME and solubilization: Soluplus - the solid solution. Drug Deliv Tech, March 2010.
9. Kolter H, Karl M, Grycke A. Hot-melt extrusion with BASF polymers: Extrusion compendium. 2nd edition. BASF Corp., Germany, 113-116, 2012.
10. Teja SB, Patil SP, Shete G, Patel S, Bansal AK. Drugexcipient behavior in polymeric amorphous solid dispersions. J Excip Food Chem, 4(3):70-94, 2013.
11. Meena A, Parikh T, Gupta SS, Serajuddin ATM. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, II: Cellulosic polymers, J Excip Food Chem, 5(1):46-55, 2014
12. Parikh T, Gupta SS, Meena A, Serajuddin ATM. Investigation of thermal and viscoelastic properties of polymers relevant to hot melt extrusion, III: Methacrylic acid copolymers and methacrylates, J Excip Food Chem, 5(1):56-64, 2014
13. Soluble Kollidon® grades, Soluble polyvinylpyrrolidone for the pharmaceutical industry, BASF technical information, 03 030730e-09, pp 3, 2013.
14. Hulsmann S, Backensfeld T, Keitel S, Bodmeier R. Melt extrusion- an alternative method for enhancing dissolution rate of 17β- estradiol hemihydrates. Eur J Pharm Biopharm, 49(3): 237-242, 2000.
15. Forster A, Henpenstall J, Tucker I, Rades T. The potential of small- scale fusion experiments and the Gordon- taylor equation to predict the suitability of drug/ polymer blends for melt extrusion. Drug Dev Ind Pharm, 27(6): 549-560, 2001.
16. Smikalla M, Urbanetz N. The influence of povidone K 17 on the storage stability of solid dispersions of nimodipine and polyethylene glycol. Eur J Pharm Biopharm, 66(1): 106-112, 2007.
17. Maniruzzaman M, Rana M, Boateng J, Mitchell J, Douroumis D. Dissolution enhancement of poorly water soluble APIs processes by hot- melt extrusion using hydrophilic polymers. Drug Dev Ind Pharm, 39: 218-227, 2013.
18. Hancock BC, Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci, 86(1): 1-12, 1997.
19. Turi E. Thermal characterization of polymeric materials, chapter 6, section 4, pp 597, Academic press, New York, 1981.
20. Barnes HA, Hutton J F, Walters K. An introduction to rheology. Elsevier, Amsterdam, 1989.
21. Ferry J. Viscoelastic properties of polymers, third edition, chapter 2, John Wiley and Sons, Inc., New York, pp 41-46, 1980.
22. Kollidon® VA 64, BASF technical information, 03 030506e-06, pp 3, 2011.
23. Soluplus® BASF technical information, 03 090801e-04, pp 2, 2010.
24. Turi E. Thermal characterization of polymeric materials, chapter 3, pp 248, Academic press, New York, 1981.
25. Beiner M, Korus J, Lockwenz H, Schröter K, Donth E. Heat capacity spectroscopy compared to other linear response methods at the dynamic glass transition in poly (vinyl acetate). Macromol, 29(15): 5183-5189, 1996.