Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase

Journal of Cellular Biochemistry

Volumn 105, Issue 2, 2008, Pages 497-502

  Liu, Yan ^a   Rubin, Boris ^a   Bodine, Peter V N ^a   Billiard, Julia ^a  

^a PFIZER INC   (United States)

Author keywords

Receptor tyrosine kinase signaling; ROR2; Wnt signaling; Wnt5A

Indexed keywords

CALCIUM; FRIZZLED PROTEIN; GLYCOPROTEIN; GUANOSINE TRIPHOSPHATASE; HOMODIMER; LOW DENSITY LIPOPROTEIN; MEMBRANE RECEPTOR; PROTEIN C JUN; ROR2 TYROSINE KINASE RECEPTOR; TYROSINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; WNT3A PROTEIN; WNT5A PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DOWN REGULATION; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DIMERIZATION; ENZYME ACTIVATION; HUMANS; MESENCHYMAL STEM CELLS; MICE; OSTEOBLASTS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 54249096215     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21848     Document Type: Article

References (24)

1. Billiard J, Komm BS, Bodine PVN. 2007. The Ror2 receptor tyrosine kinase. In: Grachevsky NO, editor. Signal transduction research trends. Hauppauge, NY: Nova Science Publishers. pp 171-186.
2. Billiard J, Way DS, Seestaller-Wehr LM, Moran RA, Mangine A, Bodine PV. 2005. The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol Endocrinol 19:90-101.
3. Boland GM, Perkins G, Hall DJ, Tuan RS. 2004. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 93:1210-1230.
4. de Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, van Blitterswijk C. 2004. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone 34:818-826.
5. Engler TA, Henry JR, Malhotra S, Cunningham B, Furness K, Brozinick J, Burkholder TP, Clay MP, Clayton J, Diefenbacher C, Hawkins E, Iversen PW, Li Y, Lindstrom TD, Marquart AL, McLean J, Mendel D, Misener E, Briere D, O'Toole JC, Porter WJ, Queener S, Reel JK, Owens RA, Brier RA, Eessalu TE, Wagner JR, Campbell RM, Vaughn R. 2004. Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7, 1-hi]indol-7-yl)pyrrole-2,5-dion es as highly selective and potent inhibitors of glycogen synthase kinase-3. J Med Chem 47:3934-3937.
6. Forrester WC. 2002. The Ror receptor tyrosine kinase family. Cell Mol Life Sci 59:83-96.
7. Hikasa H, Shibata M, Hiratani I, Taira M. 2002. The Xenopus receptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling. Development 129:5227-5239.
8. Huelsken J, Birchmeier W. 2001. New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11:547-553.
9. Kuhl M, Sheldahl LC, Park M, Miller JR, Moon RT. 2000. The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape. Trends Genet 16:279-283.
10. Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis MF, Li J, Nishita M, Minami Y, Minoo P. 2008. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol 9:11.
11. Liu Y, Bhat RA, Seestaller-Wehr LM, Fukayama S, Mangine A, Moran RA, Komm BS, Bodine PV, Billiard J. 2007a. The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation. Mol Endocrinol 21:376-387.
12. Liu Y, Ross JF, Bodine PV, Billiard J. 2007b. Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. Mol Endocrinol 21:3050-3061.
13. MacKeigan JP, Murphy LO, Blenis J. 2005. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 7:591-600.
14. MacLeod RJ, Hayes M, Pacheco I. 2007. Wnt5a secretion stimulated by the extracellular calcium-sensing receptor inhibits defective Wnt signaling in colon cancer cells. Am J Physiol Gastrointest Liver Physiol 293:G403-G411.
15. Mikels AJ, Nusse R. 2006. Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 4:e115.
16. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, Koshida I, Suzuki K, Yamada G, Schwabe GC, Mundlos S, Shibuya H, Takada S, Minami Y. 2003. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8:645-654.
17. Pacheco JR, Chen KP, Hayes MA. 2007. A study on the condition for differential electrophoretic transport at a channel entrance. Electrophoresis 28:1027-1035.
18. Paganoni S, Ferreira A. 2005. Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2. J Cell Sci 118:433-446.
19. Sammar M, Stricker S, Schwabe GC, Sieber C, Hartung A, Hanke M, Oishi I, Pohl J, Minami Y, Sebald W, Mundlos S, Knaus P. 2004. Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2. Genes Cells 9:1227-1238.
20. Schambony A, Wedlich D. 2007. Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev Cell 12:779-792.
21. Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S. 2007. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol 9:1273-1285.
22. Weston CR, Davis RJ. 2002. The JNK signal transduction pathway. Curr Opin Genet Dev 12:14-21.
23. Wodarz A, Nusse R. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
24. Yamamoto H, Yoo SK, Nishita M, Kikuchi A, Minami Y. 2007. Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12:1215-1223.