Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 23246-23254

  Dodge, Michael E ^a   Moon, Jesung ^b   Tuladhar, Rubina ^a   Lu, Jianming ^b   Jacob, Leni S ^a   Zhang, Li Shu ^a   Shi, Heping ^b   Wang, Xiaolei ^b   Moro, Enrico ^c   Mongera, Alessandro ^c   Argenton, Francesco ^c   Karner, Courtney M ^a,b   Carroll, Thomas J ^a,b   Chen, Chuo ^b   Amatruda, James F ^a,b   Lum, Lawrence ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CATENIN SIGNALING; CELLULAR RESPONSE; EMBRYONIC DEVELOPMENT; FUNCTIONAL REDUNDANCY; GENE FUNCTION; GLYCOGEN SYNTHASE KINASE-3; IN-VIVO; INTERCELLULAR SIGNALING; MEMBRANE-BOUND; SMALL MOLECULES; TANKYRASE; TISSUE HOMEOSTASIS; TRANSCRIPTIONAL CO-ACTIVATORS; WNT SIGNALING; ZEBRAFISH DEVELOPMENT;

ANIMALS; CHEMICAL COMPOUNDS; GENES; MOLECULES; PROTEINS; TISSUE;

SIGNALING;

ACYLTRANSFERASE; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; O ACYLTRANSFERASE PORCUPINE; TANKYRASE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT10B PROTEIN; WNT3A PROTEIN;

ACYLATION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE FUNCTION; HUMAN; HUMAN CELL; LIGAND BINDING; MATRIX ATTACHMENT REGION; MORPHOGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTINEOPLASTIC AGENTS; BETA CATENIN; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG DESIGN; ENZYME INHIBITORS; GUIDED TISSUE REGENERATION; HEK293 CELLS; HELA CELLS; HUMANS; KIDNEY; MEMBRANE PROTEINS; ORGAN CULTURE TECHNIQUES; TISSUE SCAFFOLDS; WNT SIGNALING PATHWAY; ZEBRAFISH;

DANIO RERIO; VERTEBRATA;

EID: 84863300046     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.372029     Document Type: Article

References (32)

1. Angers, S., and Moon, R. T. (2009) Proximal events in Wnt signal transduction. Nature Reviews 10, 468-477
2. van Amerongen, R., and Nusse, R. (2009) Towards an integrated view of Wnt signaling in development. Development 136, 3205-3214
3. Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., Wei, S., Hao, W., Kilgore, J., Williams, N. S., Roth, M. G., Amatruda, J. F., Chen, C., and Lum, L. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100-107
4. Huang, H., and He, X. (2008) Wnt/beta-catein signaling: new (and old) players and new insights. Curr. Opin. Cell Biol. 20, 119-125
5. Yang, J., Brown, M. S., Liang, G., Grishin, N. V., and Goldstein, J. L. (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetitestimulating peptide hormone. Cell 132, 387-396 (Pubitemid 351192001)
6. Ren, Y., Lee, M. Y., Schliffke, S., Paavola, J., Amos, P. J., Ge, X., Ye, M., Zhu, S., Senyei, G., Lum, L., Ehrlich, B. E., and Qyang, Y. (2011) Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J. Mol. Cell Cardiol. 51, 280-287
7. Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., and Clevers, H. (2011) Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469, 415-418
8. ten Berge, D., Kurek, D., Blauwkamp, T., Koole, W., Maas, A., Eroglu, E., Siu, R. K., and Nusse, R. (2011) Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat. Cell Biol. 13, 1070-1075
9. Gao, X., Arenas-Ramirez, N., Scales, S. J., and Hannoush, R. N. (2011) Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes. FEBS Lett. 585, 2501-2506
10. Barrott, J. J., Cash, G. M., Smith, A. P., Barrow, J. R., and Murtaugh, L. C. (2011) Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc. Natl. Acad. Sci. U.S.A. 108, 12752-12757
11. Galli, L. M., Barnes, T. L., Secrest, S. S., Kadowaki, T., and Burrus, L. W. (2007) Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube. Development 134, 3339-3348 (Pubitemid 350018434)
12. Coombs, G. S., Yu, J., Canning, C. A., Veltri, C. A., Covey, T. M., Cheong, J. K., Utomo, V., Banerjee, N., Zhang, Z. H., Jadulco, R. C., Concepcion, G. P., Bugni, T. S., Harper, M. K., Mihalek, I., Jones, C. M., Ireland, C. M., and Virshup, D. M. (2010) WLS-dependent secretion ofWNT3Arequires Ser209 acylation and vacuolar acidification. J. Cell Science 123, 3357-3367
13. Herr, P., and Basler, K. (2012) Porcupine-mediated lipidation is required for Wnt recognition by Wls. Dev. Biol. 361, 392-402
14. Merkel, C. E., Karner, C. M., and Carroll, T. J. (2007) Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatric Nephrology 22, 1825-1838 (Pubitemid 47506222)
15. Lee, J. M., Kim, I. S., Kim, H., Lee, J. S., Kim, K., Yim, H. Y., Jeong, J., Kim, J. H., Kim, J. Y., Lee, H., Seo, S. B., Rosenfeld, M. G., Kim, K. I., and Baek, S. H. (2010) RORα attenuates Wnt/β-catenin signaling by PKCα-dependent phosphorylation in colon cancer. Mol. Cell 37, 183-195
16. Jacob, L. S., Wu, X., Dodge, M. E., Fan, C. W., Kulak, O., Chen, B., Tang, W., Wang, B., Amatruda, J. F., and Lum, L. (2011) Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Science Signaling 4, ra4
17. Gao, C., and Chen, Y. G. (2010) Dishevelled: The hub of Wnt signaling. Cell Signal 22, 717-727
18. Huang, S. M., Mishina, Y. M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G. A., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S., Hild, M., Shi, X., Wilson, C. J., Mickanin, C., Myer, V., Fazal, A., Tomlinson, R., Serluca, F., Shao, W., Cheng, H., Shultz, M., Rau, C., Schirle, M., Schlegl, J., Ghidelli, S., Fawell, S., Lu, C., Curtis, D., Kirschner, M. W., Lengauer, C., Finan, P. M., Tallarico, J. A., Bouwmeester, T., Porter, J. A., Bauer, A., and Cong, F. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature 461, 614-620
19. Moro, E., Ozhan-Kizil, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R. M., Bournele, D., Domenichini, A., Valdivia, L. E., Lum, L., Chen, C., Amatruda, J. F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Dev. Biol. 366, 327-340
20. Stoick-Cooper, C. L., Weidinger, G., Riehle, K. J., Hubbert, C., Major, M. B., Fausto, N., and Moon, R. T. (2007) Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development 134, 479-489 (Pubitemid 46332485)
21. Marlow, F., Gonzalez, E. M., Yin, C., Rojo, C., and Solnica-Krezel, L. (2004) No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Development 131, 203-216 (Pubitemid 38111427)
22. Biechele, S., Cox, B. J., and Rossant, J. (2011) Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev. Biol. 355, 275-285
23. Roszko, I., Sawada, A., and Solnica-Krezel, L. (2009) Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Seminars Cell Dev. Biol. 20, 986-997
24. Sepich, D. S., Usmani, M., Pawlicki, S., and Solnica-Krezel, L. (2011) Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements. Development 138, 543-552
25. Buckles, G. R., Thorpe, C. J., Ramel, M. C., and Lekven, A. C. (2004) Combinatorial Wnt control of zebrafish midbrain-hindbrain boundary formation. Mech. Dev. 121, 437-447 (Pubitemid 38624539)
26. Ekker, M., Wegner, J., Akimenko, M. A., and Westerfield, M. (1992) Coordinate embryonic expression of three zebrafish engrailed genes. Development 116, 1001-1010 (Pubitemid 23042440)
27. Bartscherer, K., and Boutros, M. (2008) Regulation of Wnt protein secretion and its role in gradient formation. EMBO Rep. 9, 977-982
28. Port, F., and Basler, K. (2010) Wnt trafficking: new insights into Wnt maturation, secretion and spreading. Traffic 11, 1265-1271
29. Chen, Q., Takada, R., and Takada, S. (2012) Deficiency of Porcupine, an O-acyltransferase gene, impairs convergent extension during gastrulation in zebrafish embryos and does not affect equivalently the trafficking of different Wnt proteins. J. Cell Sci., in press
30. Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., and Takada, S. (2006) Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev. Cell 11, 791-801 (Pubitemid 44804277)
31. Mulligan, K. A., Fuerer, C., Ching, W., Fish, M., Willert, K., and Nusse, R. (2012) Secreted Wingless-interacting molecule (Swim) promotes longrange signaling by maintaining Wingless solubility. Proc. Natl. Acad. Sci. U.S.A. 109, 370-377
32. Buglino, J. A., and Resh, M. D. (2008) Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of Sonic Hedgehog. J. Biol. Chem. 283, 22076-22088