Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

BMC Biology

Volumn 12, Issue , 2014, Pages

  Kumar, Sumit ^a   Žigman, Mihaela ^a   Patel, Trushar R ^b,d   Trageser, Benjamin ^a   Gross, Julia C ^a   Rahm, Karolin ^c   Boutros, Michael ^a   Gradl, Dietmar ^c   Steinbeisser, Herbert ^a   Holstein, Thomas ^a   Stetefeld, Jörg ^b   Özbek, Suat ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF MANITOBA   (Canada)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Frizzled; Wnt; Wnt signaling; Wnt3a mutation analysis

Indexed keywords

FRIZZLED 8 PROTEIN, MOUSE; G PROTEIN COUPLED RECEPTOR; MUTANT PROTEIN; WNT3A PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ANIMAL EMBRYO; ARTICLE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE; POINT MUTATION; PRENATAL DEVELOPMENT; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SOLUBILITY; STRUCTURE ACTIVITY RELATION; WNT SIGNALING PATHWAY; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; EMBRYO, NONMAMMALIAN; HEK293 CELLS; HUMANS; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WNT SIGNALING PATHWAY; WNT3A PROTEIN; ZEBRAFISH;

METAZOA;

EID: 84903141125     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-12-44     Document Type: Article

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