Endothelial inflammatory transcriptional responses to an altered plasma exposome following inhalation of diesel emissions

Inhalation Toxicology

Volumn 27, Issue 5, 2015, Pages 272-280

  Schisler, Jonathan C ^a   Ronnebaum, Sarah M ^a   Madden, Michael ^b   Channell, Meghan ^c   Campen, Matthew ^c   Willis, Monte S ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Air pollution; Diesel; Endothelium; Inflammation; Particulate matter; Plasma

Indexed keywords

CYTOKINE; INTERLEUKIN 6; LIPID; RNA; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTOME; TUMOR NECROSIS FACTOR ALPHA; AIR POLLUTANT; AUTACOID; EXHAUST GAS; IL6 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ARTICLE; CORONARY ARTERY; ENDOTHELIUM CELL; EXHAUST GAS; GENE EXPRESSION; GENOME; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NORMAL HUMAN; ONTOGENY; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TOXIC INHALATION; UPREGULATION; AIR POLLUTANT; BLOOD; CELL CULTURE; CORONARY BLOOD VESSEL; CYTOLOGY; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; METABOLISM; TOXICITY;

AIR POLLUTANTS; CELLS, CULTURED; CORONARY VESSELS; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASMA; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VEHICLE EMISSIONS;

EID: 84934764938     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2015.1030481     Document Type: Article

References (60)

1. Analitis A , Katsouyanni K , Dimakopoulou K , et al. (2006). Short-term effects of ambient particles on cardiovascular and respiratory mortality. Epidemiology 17:230-3.
2. Ananthakrishnan AN , McGinley EL , Binion DG , Saeian K. (2011). Ambient air pollution correlates with hospitalizations for inflammatory bowel disease: an ecologic analysis. Inflammatory Bowel Dis 17: 1138-45.
3. Bai N , Kido T , Suzuki H , et al. (2011). Changes in atherosclerotic plaques induced by inhalation of diesel exhaust. Atherosclerosis 216: 299-306.
4. Bauer RN , Diaz-Sanchez D , Jaspers I. (2012). Effects of air pollutants on innate immunity: the role of toll-like receptors and nucleotide-binding oligomerization domain-like receptors. J Allergy Clin Immunol 129: 14-24; quiz 25-16.
5. Beamish LA , Osornio-Vargas AR , Wine E. (2011). Air pollution: an environmental factor contributing to intestinal disease. J Crohns Colitis 5:279-86.
6. Bezemer GF , Sagar S , van Bergenhenegouwen J , et al. (2012). Dual role of toll-like receptors in asthma and chronic obstructive pulmonary disease. Pharmacol Rev 64:337-58.
7. Brook RD , Rajagopalan S , Pope III CA , et al. (2010). Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American heart association. Circulation 121: 2331-78.
8. Campen MJ. (2012). Vascular endothelium as a target of diesel particulate matter-associated toxicants. Arch Toxicol 86:517-18.
9. Campen MJ , Lund AK , Knuckles TL , et al. (2010). Inhaled diesel emissions alter atherosclerotic plaque composition in apoe(-/-) mice. Toxicol Appl Pharmacol 242:310-17.
10. Campen M , Robertson S , Lund A , et al. (2014). Engine exhaust particulate and gas phase contributions to vascular toxicity. Inhal Toxicol 26:353-60.
11. Channell MM , Paffett ML , Devlin RB , et al. (2012). Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model. Toxicol Sci 127:179-86.
12. Cherng TW , Paffett ML , Jackson-Weaver O , et al. (2011). Mechanisms of diesel-induced endothelial nitric oxide synthase dysfunction in coronary arterioles. Environ Health Perspect 119:98-103.
13. Dockery DW , Pope III CA , Xu X , et al. (1993). An association between air pollution and mortality in six U.S. cities. N Engl J Med 329: 1753-9.
14. Eisenhart C. (1947). The assumptions underlying the analysis of variance. Biometrics 3:1-21.
15. Farhat SC , Silva CA , Orione MA , et al. (2011). Air pollution in autoimmune rheumatic diseases: a review. Autoimmun Rev 11:14-21.
16. Hubbard HF , Sobus JR , Pleil JD , et al. (2009). Application of novel method to measure endogenous vocs in exhaled breath condensate before and after exposure to diesel exhaust. J chromatogr B Anal Technol Biomed Life Sci 877:3652-8.
17. Kampfrath T , Maiseyeu A , Ying Z , et al. (2011). Chronic fine particulate matter exposure induces systemic vascular dysfunction via nadph oxidase and tlr4 pathways. Circ Res 108:716-26.
18. Kaplan G. (2011). Air pollution and the inflammatory bowel diseases. Inflamm Bowel Dis 17:1146-8.
19. Kitchen RR , Sabine VS , Sims AH , et al. (2010). Correcting for intraexperiment variation in illumina beadchip data is necessary to generate robust gene-expression profiles. BMC Genomics 11:134.
20. Knuckles TL , Buntz JG , Paffett M , et al. (2011). Formation of vascular s-nitrosothiols and plasma nitrates/nitrites following inhalation of diesel emissions. J Toxicol Environ Health A 74: 828-37.
21. Knuckles TL , Lund AK , Lucas SN , Campen MJ. (2008). Diesel exhaust exposure enhances venoconstriction via uncoupling of enos. Toxicol Appl Pharmacol 230:346-51.
22. Konigshoff M , Kneidinger N , Eickelberg O. (2009). Tgf-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen. Swiss Med Wkly 139:554-63.
23. Langrish JP , Bosson J , Unosson J , et al. (2012). Cardiovascular effects of particulate air pollution exposure: time course and underlying mechanisms. J Intern Med 272:224-39.
24. Langrish JP , Unosson J , Bosson J , et al. (2013). Altered nitric oxide bioavailability contributes to diesel exhaust inhalation-induced cardiovascular dysfunction in man. J Am Heart Assoc 2:e004309.
25. Le Tertre A , Medina S , Samoli E , et al. (2002). Short-term effects of particulate air pollution on cardiovascular diseases in eight european cities. J Epidemiol Commun Health 56:773-9.
26. Lim H , Kim YU , Sun H , et al. (2014). Proatherogenic conditions promote autoimmune t helper 17 cell responses in vivo. Immunity 40: 153-65.
27. Lucking AJ , Lundback M , Barath SL , et al. (2011). Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation 123:1721-8.
28. Lund AK , Lucero J , Harman M , et al. (2011). The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions. Am J Respir Crit Care Med 184:82-91.
29. Lund AK , Lucero J , Lucas S , et al. (2009). Vehicular emissions induce vascular mmp-9 expression and activity associated with endothelin-1-mediated pathways. Arterioscler Thromb Vasc Biol 29: 511-17.
30. Madden MC , Stevens T , Case M , et al. (2014). Diesel exhaust modulates ozone-induced lung function decrements in healthy human volunteers. Part Fibre Toxicol 11:37.
31. McDonald JD , Campen MJ , Harrod KS , et al. (2011). Engineoperating load influences diesel exhaust composition and cardiopulmonary and immune responses. Environ Health Perspect 119: 1136-41.
32. Mi H , Muruganujan A , Thomas PD. (2013). Panther in 2013: modeling the evolution of gene function , and other gene attributes , in the context of phylogenetic trees. Nucleic Acids Res 41:D377-86.
33. Mi H , Thomas P. (2009). Panther pathway: an ontology-based pathway database coupled with data analysis tools. Methods Mol Biol 563:123-40.
34. Miller MR , McLean SG , Duffin R , et al. (2013). Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice. Part Fibre Toxicol 10:61.
35. Mills NL , Tornqvist H , Gonzalez MC , et al. (2007). Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Eng J Med 357:1075-82.
36. Mills NL , Tornqvist H , Robinson SD , et al. (2005). Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112:3930-6.
37. Nawrot TS , Perez L , Kunzli N , et al. (2011). Public health importance of triggers of myocardial infarction: a comparative risk assessment. Lancet 377:732-40.
38. Norata GD , Grigore L , Raselli S , et al. (2006). Triglyceriderich lipoproteins from hypertriglyceridemic subjects induce a proinflammatory response in the endothelium: molecular mechanisms and gene expression studies. J Mol Cell Cardiol 40:484-94.
39. Norata GD , Pirillo A , Callegari E , et al. (2003). Gene expression and intracellular pathways involved in endothelial dysfunction induced by VLDL and oxidised VLDL. Cardiovasc Res 59:169-80.
40. Omori T , Fujimoto G , Yoshimura I , et al. (2003). Effects of particulate matter on daily mortality in 13 Japanese cities. J Epidemiol 13: 314-22.
41. Ostro B , Broadwin R , Green S , et al. (2006). Fine particulate air pollution and mortality in nine California counties: results from calfine. Environ Health Perspect 114:29-33.
42. Peters A , von Klot S , Heier M , et al. (2004). Exposure to traffic and the onset of myocardial infarction. N Engl J Med 351:1721-30.
43. Pirillo A , Norata GD , Catapano AL. (2013). Lox-1 , oxldl , and atherosclerosis. Mediat Inflamm 2013:152786.
44. Pope III CA. (1989). Respiratory disease associated with community air pollution and a steel mill , Utah valley. Am J Public Health 79: 623-8.
45. Rao X , Zhong J , Maiseyeu A , et al. (2014). Cd36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. Circ Res 115:770-80.
46. Rich DQ , Schwartz J , Mittleman MA , et al. (2005). Association of shortterm ambient air pollution concentrations and ventricular arrhythmias. Am J Epidemiol 161:1123-32.
47. Robertson S , Colombo ES , Lucas SN , et al. (2013). Cd36 mediates endothelial dysfunction downstream of circulating factors induced by o3 exposure. Toxicol Sci 134:304-11.
48. Sancini G , Farina F , Battaglia C , et al. (2014). Health risk assessment for air pollutants: alterations in lung and cardiac gene expression in mice exposed to milano winter fine particulate matter (pm2.5). PLoS one 9: e109685.
49. Schmid R , Baum P , Ittrich C , et al. (2010). Comparison of normalization methods for illumina beadchip humanht-12 v3. BMC Genomics 11:349.
50. Shi W , Chen F , Cardoso WV. (2009). Mechanisms of lung development: contribution to adult lung disease and relevance to chronic obstructive pulmonary disease. Proc Am Thorac Soc 6:558-63.
51. Shih TS , Lai CH , Hung HF , et al. (2008). Elemental and organic carbon exposure in highway tollbooths: a study of Taiwanese toll station workers. Sci Total Environ 402:163-70.
52. Sikorski K , Czerwoniec A , Bujnicki JM , et al. (2011). Stat1 as a novel therapeutical target in pro-atherogenic signal integration of ifngamma , tlr4 and il-6 in vascular disease. Cytokine Growth Factor Rev 22: 211-19.
53. Silverstein RL , Febbraio M. (2009). Cd36 , a scavenger receptor involved in immunity , metabolism , angiogenesis , and behavior. Sci Signal 2: re3.
54. Sobus JR , Pleil JD , Madden MC , et al. (2008). Identification of surrogate measures of diesel exhaust exposure in a controlled chamber study. Environ Sci Technol 42:8822-8.
55. Subramanian A , Tamayo P , Mootha VK , et al. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545-50.
56. USEPA (U.S. Environmental Protection Agency). (2002). Health assessment document for diesel engine exhaust. Washington , DC: USEPA.
57. Wingender E , Chen X , Fricke E , et al. (2001). The transfac system on gene expression regulation. Nucleic Acids Res 29:281-3.
58. Wingender E , Chen X , Hehl R , et al. (2000). Transfac: an integrated system for gene expression regulation. Nucleic Acids Res 28:316-19.
59. Zanobetti A , Schwartz J. (2009). The effect of fine and coarse particulate air pollution on mortality: a national analysis. Environ Health Perspect 117:898-903.
60. Zhang X , Duan H , Gao F , et al. (2015). Increased micronucleus , nucleoplasmic bridge , and nuclear bud frequencies in the peripheral blood lymphocytes of diesel engine exhaust-exposed workers. Toxicol Sci 143:408-17.