The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissions

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 1, 2011, Pages 82-91

  Lund, Amie K ^a   Lucero, JoAnn ^a   Harman, Melissa ^a   Madden, Michael C ^b   McDonald, Jacob D ^a   Seagrave, Jean Clare ^a   Campen, Matthew J ^c  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Atherosclerosis; Endothelin 1; Matrix metalloproteinase; Oxidized low density lipoprotein; Particulate matter

Indexed keywords

ENDOTHELIN 1; GELATINASE B; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; REACTIVE OXYGEN METABOLITE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; CARDIOVASCULAR EFFECT; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXHAUST GAS; HUMAN; MALE; MOUSE; NONHUMAN; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM;

ADOLESCENT; ADULT; AIR POLLUTANTS; ANIMALS; ANTIBODIES, NEUTRALIZING; AORTA; APOLIPOPROTEINS E; ATHEROSCLEROSIS; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; HUMANS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MALE; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES; UP-REGULATION; VEHICLE EMISSIONS; YOUNG ADULT;

EID: 80051565625     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201012-1967OC     Document Type: Article

References (40)

1. Pope CA III, Muhlestein JB, May HT, Renlund DG, Anderson JL, Horne BD. Ischemic heart disease events triggered by short-term exposure to fine particulate air pollution. Circulation 2006;114:2443-2448. (Pubitemid 44901516)
2. Hoffmann B, Moebus S, Möhlenkamp S, Stang A, Lehmann N, Dragano N, Schmermund A, Memmesheimer M, Mann K, Erbel R, et al, for the Heinz Nixdorf Recall Study Investigative Group. Residential exposure to traffic is associated with coronary atherosclerosis. Circulation 2007;116:489-496. (Pubitemid 47450257)
3. Peters A, von Klot S, Heier M, Trentinaglia I, Hörmann A, Wixhmann HE, Löwel H. Cooperative health research in the region of Augsburg study group. Exposure to traffic and the onset of myocardial infarction. N Engl J Med 2004;351:1721-1730.
4. Grahame TJ, Schlesinger RB. Cardiovascular health and particulate vehicular emissions: a critical evaluation of the evidence. Air Qual Atmos Health 2010;3:3-27.
5. Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aguinaldo JG, Fayad ZA, Fuster V, Lippmann M, et al Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 2005;21:3003-3010. (Pubitemid 41817662)
6. Brook RD, Rajagopalan S, Pope CA III, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, et al; on behalf of the American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism. Particulate matter air pollution and cardiovascular disease. An update to the scientific statement from the American Heart Association. Circulation 2010;121:2331-2378.
7. Lund AK, Lucero J, Lucas S, Madden M, McDonald J, Campen MJ. Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1 mediated pathways. Arterioscler Thromb Vasc Biol 2009;29:511-517.
8. Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 1996;20:707-727. (Pubitemid 26105783)
9. Sawamura T, Kume N, Aoyama T, Moriwaki H, Hoshikawa H, Aiba Y, Tanaka T, Miwa S, Katsura Y, Kita T, et al An endothelial receptor for oxidized low-density lipoprotein. Nature 1997;386:73-77. (Pubitemid 27130922)
10. Reiss AB, Anwar K, Wirkowski P. Lectin-like oxidized low density lipoprotein receptor -1 (LOX-1) in atherogenesis: a brief review. Curr Med Chem 2009;16:2641-2652.
11. Navarra T, Del Turco S, Berti S, Basta GJ. The lectin-like oxidized low-density lipoprotein receptor-1 and its soluble form: cardiovascular implications. J Atheroscler Thromb 2010;17:317-331.
12. Mehta JL, Chen J, Hermonat PL, Romeo F, Novelli G. Lectin-like oxidized low-density lipoprotein receptor (LOX-1): a critical player in the development of atherosclerosis and related disorders. Cardiovasc Res 2006;69:36-45. (Pubitemid 41814809)
13. Ishino S, Mukai T, Kume N, Asano D, Ogawa M, Kuge Y, Minami M, Kita T, Shiomi M, Saji H. Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits. Atherosclerosis 2007;95:48-56. (Pubitemid 47561943)
14. Li D, Liu L, Chen H, Sawamura T, Ranganathan S, Mehta JL. LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells. Circulation 2003;107:612-617. (Pubitemid 36176813)
15. White SJ, Sala-Newby GB, Newby AC. Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE(-/-) mouse model. Cardiovasc Pathol (In press)
16. Campen MJ, Lund AK, Knuckles TL, Conklin DF, Bishop B, Young D, Sielkop SK, Seagrave JC, Reed MD, McDonald JD. Inhaled diesel emissions alter atherosclerotic plaque composition in Apo E-/- mice. Toxicol Appl Pharmacol 2010;242:310-317.
17. Ihling C, Szombathy T, Bohrmann B, Brockhaus M, Schaefer HE, Loeffler BM. Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis. Circulation 2001;104:864-869. (Pubitemid 32778034)
18. Haug C, Schmid-Kotsas A, Zorn U, Schuett S, Gross HJ, Gruenert A, Bachem MG. Endothelin-1 synthesis and endothelin B receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is up-regulated by low density lipoproteins. J Mol Cell Cardiol 2001;33:1701-1712. (Pubitemid 32844227)
19. Ergul A, Portik-Dobos V, Giulumian AD, Molero MM, Fuchs LC. Stress up-regulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation. Am J Physiol Heart Circ Physiol 2003;285:H2225-H2232. (Pubitemid 37305969)
20. Lund AK, Knuckles TL, Obat Akata C, Shohet R, McDonald JD, Seagrave JC, Campen MJ. Exposure to gasoline exhaust results in alterations of pathways involved in atherosclerosis. Toxicol Sci 2007;95:485-494. (Pubitemid 46152621)
21. Lund AK, Lucero J, Mathews N, Harman M, Lucas S, Campen MJ. Vascular lectin-like-OxLDL scavenger receptor (LOX-1) mediates oxidative stress, endothelin-1, and matrix metalloproteinase expression in the vasculature of vehicular engine emissions-exposed mice [abstract]. Circulation 2009;120:S1154.
22. McDonald JD, Barr EB, White RK, Chow JC, Schauer JJ, Zielinska B, Grosjean E. Generation and characterization of four dilutions of diesel engine exhaust for a subchronic inhalation study. Environ Sci Technol 2004;38:2513-2522. (Pubitemid 38579851)
23. Xu S, Gao X, Potter BJ, Cao J-M, Zhang C. Anti-LOX-1 rescues endothelial function in coronary arterioles in atherosclerotic ApoE knockout mice. Arterioscler Thromb Vasc Biol 2007;27:871-877. (Pubitemid 46606719)
24. Campen MJ, Lund AK, Doyle-Eisele M, McDonald JD, Knuckles JL, Rohr A, Knipping E, Mauderly JL. A comparison of vascular effects from complex and individual air pollutants indicates a toxic role for monoxide gases. Environ Health Perspect 2010;118:921-927.
25. Murase T, Kume N, Kataoka H, Minami M, Sawamura T, Masaki T, Kita T. Identification of soluble forms of lectin-like oxidized LDL receptor-1. Arterioscler Thromb Vasc Biol 2000;20:715-720. (Pubitemid 30151686)
26. Hayashida K, Kume N, Murase T, Minami M, Nakagawa D, Inada T, Tanaka M, Ueda A, Kominami G, Kambara H, et al Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome. A novel marker for early diagnosis. Circulation 2005;112:812-818. (Pubitemid 41170066)
27. Kataoka H, Kume N, Miyamoto S, Minami M, Moriwaki H, Murase T, Sawamura T, Masaki T, Hashimoto N, Kita T. Expression of lectin-like oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions. Circulation 1999;99:3110-3117. (Pubitemid 29289075)
28. Kuge Y, Kume N, Ishino S, Takai N, Ogawa Y, Mukai T, Minami M, Shiomi M, Saji H. Prominent lectin-like oxidized low density lipoprotein (LDL) receptor-1 (LOX-1) expression in atherosclerosis lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits. Biol Pharm Bull 2008;31:1475-1482.
29. Bhaskaran K, Hajat S, Haines A, Herrett E, Wilkinson P, Smeeth L. Effects of air pollution on the incidence of myocardial infarction. Heart 2009;95:1746-1759.
30. Ogura S, Kakino A, Sato Y, Fujita Y, Iwamoto S, Otsui K, Ysohimoto R, Sawamura T. LOX-1: the multifunctional receptor underlying cardiovascular dysfunction. Circ J 2009;73:1993-1999.
31. Aoyama T, Sawamura T, Furutani Y, Matsuuoka R, Yoshida MC, Fujiwara H, Masaki T. Structure and chromosomal assignment of the human lectin-like oxidized low density lipoprotein receptor (LOX-1) gene. Biochem J 1999;339:177-184. (Pubitemid 29179305)
32. Ikeda M, Shitashige M, Yamasaki H, Sagai M, Tomita T. Oxidative modification of low density lipoprotein by diesel exhaust particles. Biol Pharm Bull 1995;18:866-871.
33. Morawietz H, Duerrschmidt N, Niemann B, Galle J, Sawamura T, Holtz J. Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1. Clin Sci (Lond) 2002;103:9S-12S. (Pubitemid 35007110)
34. Quehenberger O. Thematic review series: the immune system and atherogenesis. Molecular mechanisms regulating monocyte recruitment in atherosclerosis. J Lipid Res 2005;46:1582-1590. (Pubitemid 41099324)
35. Blankenberg S, Rupprecht HJ, Poirier O, Bickel C, Smieja M, Hafner G, Meyer J, Cambein F, Tiret L. Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation 2003;107:1579-1585. (Pubitemid 36397324)
36. de Nooijer R, Verkleij CJ, von der Thusen JH, Jukema JW, van der Wall EE, van Berkel TJ, Baker AH, Biessen EA. Lesional overexpression of MMP-9 promotes intraplaque hemorrhage in advanced lesions, but not earlier stages of atherogenesis. Arterioscler Thromb Vasc Biol 2006;26:340-346. (Pubitemid 43732197)
37. Vanhoutte D, Heymans S. TIMPs and cardiac remodeling: embracing the MMP-independent-side of the family. J Mol Cell Cardiol 2010;48:445-453.
38. Brinkley TE, Kume N, Mitsuoka H, Brown MD, Phares DA, Ferrell RE, Kita T, Hagberg JM. Variation in the human lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene is associated with plasma soluble LOX-1 levels. Exp Physiol 2008;93:1085-1090.
39. Chen Q, Reis SE, Kammerer C, Craig WY, LaPierre SE, Zimmer EL, McNamara DM, Pauly DF, Sharaf B, Holubkow R, et al Genetic variation in lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) gene and the risk of coronary artery disease. Circulation 2003;107:3146-3151. (Pubitemid 36793083)
40. Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, Xu X, Kherada N, Brook RD, Reddy KM, Padture NP, et al Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Circ Res 2011;108:716-726.