Increased micronucleus, nucleoplasmic bridge, and nuclear bud frequencies in the peripheral blood lymphocytes of diesel engine exhaust-exposed workers

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 408-417

  Zhang, Xiao ^a   Duan, Huawei ^a   Gao, Feng ^b   Li, Yuanyuan ^b   Huang, Chuanfeng ^a   Niu, Yong ^a   Gao, Weimin ^c   Yu, Shanfa ^d   Zheng, Yuxin ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c TEXAS TECH UNIVERSITY   (United States)

^d Institute of Occupational Diseases Prevention of Henan Province   (China)

Author keywords

Diesel engine exhaust; Micronucleus; Nuclear bud; Nucleoplasmic bridge; Urinary mono hydroxylated polycyclic aromatic hydrocarbons

Indexed keywords

CARCINOGEN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; AIR POLLUTANT; EXHAUST GAS; POLYCYCLIC AROMATIC HYDROCARBON;

ADULT; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINESIS; CYTOPLASM; DIESEL ENGINE; EXHAUST GAS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MICRONUCLEUS; OCCUPATIONAL EXPOSURE; PERIPHERAL LYMPHOCYTE; ADVERSE EFFECTS; AIR POLLUTANT; ANALYSIS; CHEMICALLY INDUCED; DRUG EFFECTS; GENE AMPLIFICATION; GENE TRANSLOCATION; LYMPHOCYTE; MALE; MICRONUCLEUS TEST; STATISTICS AND NUMERICAL DATA; TOXICITY; ULTRASTRUCTURE; URINE;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; CELL NUCLEUS; GENE AMPLIFICATION; HUMANS; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; OCCUPATIONAL EXPOSURE; POLYCYCLIC HYDROCARBONS, AROMATIC; TRANSLOCATION, GENETIC; VEHICLE EMISSIONS;

EID: 84924737645     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu239     Document Type: Article

References (40)

1. Attfield, M. D., Schleiff, P. L., Lubin, J. H., Blair, A., Stewart, P. A., Vermeulen, R., Coble, J. B., and Silverman, D. T. (2012). The diesel exhaust in miners study: a cohort mortality study with emphasis on lung cancer. J. Natl Cancer Inst. 104, 869-883.
2. Benbrahim-Tallaa, L., Baan, R. A., Grosse, Y., Lauby-Secretan, B., El Ghissassi, F., Bouvard, V., Guha, N., Loomis, D., Straif, K., and International Agency for Research on Cancer Monograph Working Group. (2012). Carcinogenicity of dieselengine and gasoline-engine exhausts and some nitroarenes. Lancet Oncol. 13, 663-664.
3. Bonassi, S., Znaor, A., Ceppi, M., Lando, C., Chang, W. P., Holland, N., Kirsch-Volders, M., Zeiger, E., Ban, S., Barale, R. et al. (2007). An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans. Carcinogenesis 28, 625-631.
4. Castranova, V., Ma, J. Y., Yang, H. M., Antonini, J. M., Butterworth, L., Barger, M. W., Roberts, J., and Ma, J. K. (2001). Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection. Environ. Health Perspect. 109(Suppl. 4), 609-612.
5. Coble, J. B., Stewart, P. A., Vermeulen, R., Yereb, D., Stanevich, R., Blair, A., Silverman, D. T., and Attfield, M. (2010). The diesel exhaust in miners study: II. Exposure monitoring surveys and development of exposure groups. Ann. Occup. Hyg. 54, 747-761.
6. Diesel Epidemiology Working Group. (2002). Research Directions to Improve Estimates of Human Exposure and Risk from Diesel Exhaust. Health Effects Institute, Boston, MA.
7. Duan, H., Leng, S., Pan, Z., Dai, Y., Niu, Y., Huang, C., Bin, P., Wang, Y., Liu, Q., Chen, W. et al. (2009). Biomarkers measured by cytokinesis-block micronucleus cytome assay for evaluating genetic damages induced by polycyclic aromatic hydrocarbons. Mutat. Res. 677, 93-99.
8. El-Zein, R. A., Schabath, M. B., Etzel, C. J., Lopez, M. S., Franklin, J. D., and Spitz, M. R. (2006). Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk. Cancer Res. 66, 6449-6456.
9. Fenech, M. (2002). Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov. Today 7, 1128-1137.
10. Fenech, M. (2006). Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death. Mutat. Res. 600, 58-66.
11. Fenech, M. (2007). Cytokinesis-block micronucleus cytome assay. Nat. Protoc. 2, 1084-1104.
12. Fenech, M., and Rinaldi, J. (1994). The relationship between micronuclei in human lymphocytes and plasma levels of vitamin C, vitamin E, vitamin B12 and folic acid. Carcinogenesis 15, 1405-1411.
13. Fenech, M., Chang, W. P., Kirsch-Volders, M., Holland, N., Bonassi, S., Zeiger, E., and Human MicronNucleus project. (2003). HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutat. Res. 534, 65-75.
14. Fenech, M., Holland, N., Chang, W. P., Zeiger, E., and Bonassi, S. (1999). The HUman MicroNucleus Project-An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat. Res. 428, 271-283.
15. Garshick, E., Laden, F., Hart, J. E., Davis, M. E., Eisen, E. A., and Smith, T. J. (2012). Lung cancer and elemental carbon exposure in trucking industry workers. Environ. Health Perspect. 120, 1301-1306.
16. Hallare, A. V., Gervasio, M. K., Gervasio, P. L., and Acacio-Claro, P. J. (2009). Monitoring genotoxicity among gasoline station attendants and traffic enforcers in the City of Manila using the micronucleus assay with exfoliated epithelial cells. Environ. Monit. Assess. 156, 331-341.
17. Huang, C., Yan, H., Pan, Z., Dai, Y., Niu, Y., Wang, Y., and Zheng, Y. (2010). [Using HPLC-MS/MS method to analyze monohydroxy metabolites of PAHs in urine]. Wei Sheng Yan Jiu 39, 355-357, 360.
18. IARC. (1989). IARC monographs on the evaluation of carcinogenic risks to humans. Diesel and gasoline engine exhausts and some nitroarenes. IARC Monogr. Eval. Carcinog. Risks Hum. 46, 1-458.
19. Kidane, D., Chae, W. J., Czochor, J., Eckert, K. A., Glazer, P. M., Bothwell, A. L., and Sweasy, J. B. (2014). Interplay between DNA repair and inflammation, and the link to cancer. Crit. Rev. Biochem. Mol. Biol. 49, 116-139.
20. Lewne, M., Plato, N., and Gustavsson, P. (2007). Exposure to particles, elemental carbon and nitrogen dioxide in workers exposed to motor exhaust. Ann. Occup. Hyg. 51, 693-701.
21. Minozzo, R., Deimling, L. I., and Santos-Mello, R. (2010). Cytokinesis-blocked micronucleus cytome and comet assays in peripheral blood lymphocytes of workers exposed to lead considering folate and vitamin B12 status. Mutat. Res. 697, 24-32.
22. Nefic, H., and Handzic, I. (2013). The effect of age, sex, and lifestyle factors on micronucleus frequency in peripheral blood lymphocytes of the Bosnian population. Mutat. Res. 753, 1-11.
23. NIOSH. (1999). Method 5040 issue 3 (interim): elemental carbon (diesel exhaust). In NIOSH Manual of Analytical Methods (NIOSH), 4th ed. National Institute of Occupational Safety and Health, Atlanta, GA.
24. Nordenhall, C., Pourazar, J., Ledin, M. C., Levin, J. O., Sandstrom, T., and Adelroth, E. (2001). Diesel exhaust enhances airway responsiveness in asthmatic subjects. Eur. Respir. J. 17, 909-915.
25. Odagiri, Y., Zhang, J. X., Uchida, H., Kawamura, K., Adachi, S., and Takemoto, K. (1994). Predominant induction of kinetochore-containing micronuclei by extracts of diesel exhaust particulates in cultured human lymphocytes. Environ. Mol. Mutagen. 23, 45-50.
26. Olsson, A. C., Gustavsson, P., Kromhout, H., Peters, S., Vermeulen, R., Bruske, I., Pesch, B., Siemiatycki, J., Pintos, J., Bruning, T. et al. (2011). Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. Am. J. Respir. Crit. Care Med. 183, 941-948.
27. OSHA. (1986). Coal tar pitch volatiles (CTPV), coke oven emissions (COE), and selected polynuclear aromatic hydrocarbons (PAHs). In OSHA Sampling&Analytical Methods (OSHA), Salt Lake City, UT.
28. Ostro, B., Broadwin, R., Green, S., Feng, W. Y., and Lipsett, M. (2006). Fine particulate air pollution and mortality in nine California counties: results from CALFINE. Environ. Health Perspect. 114, 29-33.
29. Puett, R. C., Hart, J. E., Yanosky, J. D., Paciorek, C., Schwartz, J., Suh, H., Speizer, F. E., and Laden, F. (2009). Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study. Environ. Health Perspect. 117, 1697-1701.
30. Salvi, S., Blomberg, A., Rudell, B., Kelly, F., Sandstrom, T., Holgate, S. T., and Frew, A. (1999). Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med. 159, 702-709.
31. Schoket, B., Poirier, M. C., Mayer, G., Torok, G., Kolozsi-Ringelhann, A., Bognar, G., Bigbee, W. L., and Vincze, I. (1999). Biomonitoring of human genotoxicity induced by complex occupational exposures. Mutat. Res. 445, 193-203.
32. Schwartz, J. (2004). The effects of particulate air pollution on daily deaths: a multi-city case crossover analysis. Occup. Environ. Med. 61, 956-961.
33. Scott, H. A., Gibson, P. G., Garg, M. L., Pretto, J. J., Morgan, P. J., Callister, R., and Wood, L. G. (2012). Relationship between body composition, inflammation and lung function in overweight and obese asthma. Respir. Res. 13, 10.
34. Silverman, D. T., Samanic, C. M., Lubin, J. H., Blair, A. E., Stewart, P. A., Vermeulen, R., Coble, J. B., Rothman, N., Schleiff, P. L., Travis, W. D. et al. (2012). The Diesel Exhaust in Miners study: a nested case-control study of lung cancer and diesel exhaust. J. Natl. Cancer Inst. 104, 855-868.
35. Song, J., and Ye, S. H. (1995). Study on the mutagenicity of diesel exhaust particles. Biomed. Environ. Sci. 8, 240-245.
36. Teass, A. W., Biagini, R. E., DeBord, D. G., NIOSH/DBBS, and Hull, R. D. (1998). Application of biological monitoring methods. In NIOSH Manual of Analytical Method (NIOSH), 4th ed., pp. 52-62. US Department of Health and Human Service, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering, Cincinnati, OH.
37. Vermeulen, R., Silverman, D. T., Garshick, E., Vlaanderen, J., Portengen, L., and Steenland, K. (2014). Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts. Environ. Health Perspect. 122, 172-177.
38. Villarini, M., Moretti, M., Fatigoni, C., Agea, E., Dominici, L., Mattioli, A., Volpi, R., and Pasquini, R. (2008). Evaluation of primary DNA damage, cytogenetic biomarkers and genetic polymorphisms for CYP1A1 and GSTM1 in road tunnel construction workers. J. Toxicol. Environ. Health A 71, 1430-1439.
39. Wichmann, H. E. (2007). Diesel exhaust particles. Inhal. Toxicol. 19(Suppl. 1), 241-244.
40. Zhao, X., Niu, J., Wang, Y., Yan, C., Wang, X., and Wang, J. (1998). Genotoxicity and chronic health effects of automobile exhaust: a study on the traffic policemen in the city of Lanzhou. Mutat. Res. 415, 185-190.