The roles of signaling pathways in epithelial-to-mesenchymal transition of PVR

Molecular Vision

Volumn 21, Issue , 2015, Pages 706-710

  Chen, Zhenna ^a   Shao, Yan ^a   Li, Xiaorong ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; CONNECTIVE TISSUE GROWTH FACTOR; JAGGED1; MITOGEN ACTIVATED PROTEIN KINASE P38; NOTCH RECEPTOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN P42; PROTEIN P44; SCATTER FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR YAP1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; WNT PROTEIN; CALCIUM BINDING PROTEIN; CTNNB1 PROTEIN, HUMAN; HGF PROTEIN, HUMAN; HIPPO PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN SERINE THREONINE KINASE; SERRATE JAGGED PROTEIN; SIGNAL PEPTIDE;

ARTICLE; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; INTRACELLULAR SIGNALING; PATHOGENESIS; PDZ DOMAIN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TGF BETA GENE; TRANSCRIPTION REGULATION; VITREORETINOPATHY; WNT SIGNALING PATHWAY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINAL DETACHMENT; VITREORETINOPATHY, PROLIFERATIVE;

BETA CATENIN; CALCIUM-BINDING PROTEINS; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCYTE GROWTH FACTOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, NOTCH; RETINAL DETACHMENT; SERRATE-JAGGED PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; VITREORETINOPATHY, PROLIFERATIVE; WNT SIGNALING PATHWAY;

EID: 84934753230     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Tamiya S, Liu L, Kaplan HJ. Epithelial-mesenchymal transition and proliferation of retinal pigment epithelial cells initiated upon loss of cell-cell contact. Invest Ophthalmol Vis Sci 2010; 51:2755-63. [PMID: 20042656].
2. Li M, Li H, Liu X, Xu D, Wang F. MicroRNA-29b regulates TGF-beta1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells by targeting AKT2. Exp Cell Res 2014; •••:[PMID: 25263462].
3. Pennock S, Haddock LJ, Eliott D, Mukai S, Kazlauskas A. Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy? Prog Retin Eye Res 2014; 40:16-34. [PMID: 24412519].
4. Cui JZ, Chiu A, Maberley D, Ma P, Samad A, Matsubara JA. Stage specificity of novel growth factor expression during development of proliferative vitreoretinopathy. Eye (Lond) 2007; 21:200-8. [PMID: 16531976].
5. Lee H, O'Meara SJ, O'Brien C, Kane R. The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 2007; 48:4291-9. [PMID: 17724219].
6. Stevenson BR, Siliciano JD, Mooseker MS, Goodenough DA. Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol 1986; 103:755-66. [PMID: 3528172].
7. Palma-Nicolás JP, Lopez-Colome AM. Thrombin induces slug-mediated E-cadherin transcriptional repression and the parallel up-regulation of N-cadherin by a transcription-independent mechanism in RPE cells. J Cell Physiol 2013; 228:581-9. [PMID: 22833386].
8. Li H, Wang H, Wang F, Gu Q, Xu X. Snail involves in the transforming growth factor beta1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells. PLoS ONE 2011; 6:e23322-[PMID: 21853110].
9. Kimoto K, Nakatsuka K, Matsuo N, Yoshioka H. p38 MAPK mediates the expression of type I collagen induced by TGF-beta 2 in human retinal pigment epithelial cells ARPE-19. Invest Ophthalmol Vis Sci 2004; 45:2431-7. [PMID: 15223827].
10. Yokoyama K, Kimoto K, Itoh Y, Nakatsuka K, Matsuo N, Yoshioka H, Kubota T. The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol 2012; 250:15-23. [PMID: 21858467].
11. Xiao W, Chen X, Liu X, Luo L, Ye S, Liu Y. Trichostatin A, a histone deacetylase inhibitor, suppresses proliferation and epithelial-mesenchymal transition in retinal pigment epithelium cells. J Cell Mol Med 2014; 18:646-55. [PMID: 24456602].
12. Parrales A, Lopez E, Lee-Rivera I, Lopez-Colome AM. ERK1/2-dependent activation of mTOR/mTORC1/p70S6K regulates thrombin-induced RPE cell proliferation. Cell Signal 2013; 25:829-38. [PMID: 23291002].
13. Kita T, Hata Y, Arita R, Kawahara S, Miura M, Nakao S, Mochizuki Y, Enaida H, Goto Y, Shimokawa H, Hafezi-Moghadam A, Ishibashi T. Role of TGF-beta in proliferative vitreoretinal diseases and ROCK as a therapeutic target. Proc Natl Acad Sci USA 2008; 105:17504-9. [PMID: 18952846].
14. Chen X, Xiao W, Liu X, Zeng M, Luo L, Wu M, Ye S, Liu Y. Blockade of Jagged/Notch pathway abrogates transforming growth factor beta2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells. Curr Mol Med 2014; 14:523-34. [PMID: 24694299].
15. Cheng HC, Ho TC, Chen SL, Lai HY, Hong KF, Tsao YP. Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells. Mol Vis 2008; 14:95-104. [PMID: 18253093].
16. Chen X, Xiao W, Wang W, Luo L, Ye S, Liu Y. The complex interplay between ERK1/2, TGFbeta/Smad, and Jagged/Notch signaling pathways in the regulation of epithelial-mesenchymal transition in retinal pigment epithelium cells. PLoS ONE 2014; 9:e96365-[PMID: 24788939].
17. Liang CM, Tai MC, Chang YH, Chen YH, Chen CL, Lu DW, Chen JT. Glucosamine inhibits epithelial-to-mesenchymal transition and migration of retinal pigment epithelium cells in culture and morphologic changes in a mouse model of proliferative vitreoretinopathy. Acta Ophthalmol (Copenh) 2011; 89:e505-14. [PMID: 21457483].
18. Lee J, Choi JG, Joo CK. TGF-beta1 regulates cell fate during epithelial-mesenchymal transition by upregulating survivin. Cell Death Dis 2013; 4:e714-[PMID: 23828577].
19. Huber LC, Distler JH, Moritz F, Hemmatazad H, Hauser T, Michel BA, Gay RE, Matucci-Cerinic M, Gay S, Distler O, Jungel A. Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. Arthritis Rheum 2007; 56:2755-64. [PMID: 17665426].
20. Bülow R, Fitzner B, Sparmann G, Emmrich J, Liebe S, Jaster R. Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells. Biochem Pharmacol 2007; 74:1747-57. [PMID: 17889833].
21. Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A. Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res 2002; 278:184-97. [PMID: 12169274].
22. Blanchard F, Chipoy C. Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases? Drug Discov Today 2005; 10:197-204. [PMID: 15708534].
23. Facchetti F, Previdi S, Ballarini M, Minucci S, Perego P, La Porta CA. Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. Apoptosis 2004; 9:573-82. [PMID: 15314285].
24. Saika S, Yamanaka O, Sumioka T, Miyamoto T, Miyazaki K, Okada Y, Kitano A, Shirai K, Tanaka S, Ikeda K. Fibrotic disorders in the eye: Targets of gene therapy. Prog Retin Eye Res 2008; 27:177-96. [PMID: 18243038].
25. Bakin AV, Rinehart C, Tomlinson AK, Arteaga CL. p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration. J Cell Sci 2002; 115:3193-206. [PMID: 12118074].
26. Jun EJ, Kim HS, Kim YH. Role of HGF/c-Met in serum-starved ARPE-19 cells. Korean J Ophthalmol 2007; 21:244-50. [PMID: 18063891].
27. Grierson I, Heathcote L, Hiscott P, Hogg P, Briggs M, Hagan S. Hepatocyte growth factor/scatter factor in the eye. Prog Retin Eye Res 2000; 19:779-802. [PMID: 11029554].
28. Ricker LJ, Kijlstra A, Kessels AG, de Jager W, Liem AT, Hendrikse F, La Heij EC. Interleukin and growth factor levels in subretinal fluid in rhegmatogenous retinal detachment: a case-control study. PLoS ONE 2011; 6:e19141-[PMID: 21556354].
29. Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res 2006; 83:212-22. [PMID: 16563380].
30. Cui J, Lei H, Samad A, Basavanthappa S, Maberley D, Matsubara J, Kazlauskas A. PDGF receptors are activated in human epiretinal membranes. Exp Eye Res 2009; 88:438-44. [PMID: 19032953].
31. Lei H, Velez G, Cui J, Samad A, Maberley D, Matsubara J, Kazlauskas A. N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol 2010; 177:132-40. [PMID: 20489144].
32. Pennock S, Rheaume MA, Mukai S, Kazlauskas A. A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol 2011; 179:2931-40. [PMID: 22035642].
33. Lei H, Velez G, Hovland P, Hirose T, Gilbertson D, Kazlauskas A. Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci 2009; 50:3394-403. [PMID: 19324843].
34. Lei H, Rheaume MA, Velez G, Mukai S, Mazlauskas A. Expression of PDGFRalpha is a determinant of the PVR potential of ARPE19 cells. Invest Ophthalmol Vis Sci 2011; 52:5016-21. [PMID: 21642621].
35. Lei H, Kazlauskas A. A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor alpha. Mol Cell Biol 2014; 34:110-22. [PMID: 24190966].
36. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C. Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 2005; 8:727-38. [PMID: 15866163].
37. Becker SF, Langhe R, Huang C, Wedlich D, Kashef J. Giving the right tug for migration: Cadherins in tissue movements. Arch Biochem Biophys 2012; 524:30-42. [PMID: 22387375].
38. Chen HC, Zhu YT, Chen SY, Tseng SC. Wnt signaling induces epithelial-mesenchymal transition with proliferation in ARPE-19 cells upon loss of contact inhibition. Lab Invest 2012; 92:676-87. [PMID: 22391957].
39. Umazume K, Tsukahara R, Liu LH, Fernandez de Castro JP, McDonald K, Kaplan HJ, Tamiya S. Role of Retinal Pigment Epithelial Cell β-Catenin Signaling in Experimental Proliferative Vitreoretinopathy. Am J Pathol 2014; 184:1419-28. [PMID: 24656918].
40. Burke JM. Epithelial phenotype and the RPE: Is the answer blowing in the Wnt? Prog Retin Eye Res 2008; 27:579-95. [PMID: 18775790].
41. Xiao H, Jiang N, Zhou B, Liu Q, Du C. TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma. Cancer Sci 2015; 106:151-9. [PMID: 25495189].
42. Lei QY, Zhang H, Zhao B, Zha ZY, Bai F, Pei XH, Zhao S, Xiong Y, Guan KL. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 2008; 28:2426-36. [PMID: 18227151].
43. Yang N, Morrison CD, Liu P, Miecznikowski J, Bshara W, Han S, Zhu Q, Omilian AR, Li X, Zhang J. TAZ induces growth factor-independent proliferation through activation of EGFR ligand amphiregulin. Cell Cycle 2012; 11:2922-30. [PMID: 22825057].
44. Wang Q, Xu Z, An Q, Jiang D, Wang L, Liang B, Li Z. TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells. Mol Med Rep 2015; 11:982-8. [PMID: 25354978].