PDGF receptors are activated in human epiretinal membranes

Experimental Eye Research

Volumn 88, Issue 3, 2009, Pages 438-444

  Cui, Jing ^a   Lei, Hetian ^b   Samad, Arif ^c   Basavanthappa, Sreenivasa ^b   Maberley, David ^a   Matsubara, Joanne ^a   Kazlauskas, Andrius ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

glial cells; PDGF; PDGF receptor; proliferative vitreoretinopathy; PVR; RPE cells

Indexed keywords

PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR C;

ARTICLE; CONTROLLED STUDY; EPIRETINAL MEMBRANE; GLIA CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VITREORETINOPATHY;

EPIRETINAL MEMBRANE; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOKINES; NEUROGLIA; PLATELET-DERIVED GROWTH FACTOR; PROTEIN ISOFORMS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VITREORETINOPATHY, PROLIFERATIVE;

EID: 61549117508     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.10.020     Document Type: Article

References (35)

1. Andrews A., Balciunaite E., Leong F.L., Tallquist M., Soriano P., Refojo M., and Kazlauskas A. Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2683-2689
2. Bergsten E., Uutela M., Li X., Pietras K., Ostman A., Heldin C.H., Alitalo K., and Eriksson U. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. Nat. Cell Biol. 3 (2001) 512-516
3. Bernard A., and Kazlauskas A. Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. Exp. Cell Res. 253 (1999) 704-712
4. Campochiaro P.A. Mechanisms in ophthalmic disease: pathogenic mechanisms in proliferative vitreoretinopathy. Arch. Ophthalmol. 115 (1997) 237-241
5. Campochiaro P.A., Hackett S.F., and Vinores S.A. Growth Factors in the Retina and Retinal Pigmented Epithelium. Progress in Retinal and Eye Research (1996), Elsevier Science Ltd. pp. 547-567
6. Campochiaro P.A., Hackett S.F., Vinores S.A., Freund J., Csaky C., LaRochelle W., Henderer J., Johnson M., Rodriguez I.R., and Friedman Z. Platelet-derived growth factor is an autocrine growth stimulator in retinal pigmented epithelial cells. J. Cell. Sci. 107 (1994) 2459-2469
7. Campochiaro P.A., Sugg R., Grotendorst G., and Hjelmeland L.M. Retinal pigment epithelial cells produce PDGF-like proteins and secrete them into their media. Exp. Eye Res. 49 (1989) 217-227
8. Carrington L., McLeod D., and Boulton M. IL-10 and antibodies to TGF-beta2 and PDGF inhibit RPE-mediated retinal contraction. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1210-1216
9. Cassidy L., Barry P., Shaw C., Duffy J., and Kennedy S. Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Br. J. Ophthalmol. 82 (1998) 181-185
10. Charteris D.G. Growth factors in proliferative vitreoretinopathy. Br. J. Ophthalmol. 82 (1998) 106
11. Chen Y.S., Hackett S.F., Schoenfeld C.L., Vinores M.A., Vinores S.A., and Campochiaro P.A. Localisation of vascular endothelial growth factor and its receptors to cells of vascular and avascular epiretinal membranes. Br. J. Ophthalmol. 81 (1997) 919-926
12. Choudhury P., Chen W., and Hunt R.C. Production of platelet-derived growth factor by interleukin-1β and transforming growth factor-β-stimulated retinal pigment epithelial cells leads to contraction of collagen gels. Invest. Ophthalmol. Vis. Sci. 38 (1997) 824-833
13. Cui J.Z., Chiu A., Maberley D., Ma P., Samad A., and Matsubara J.A. Stage specificity of novel growth factor expression during development of proliferative vitreoretinopathy. Eye 21 (2007) 200-208
14. Elner S.G., Elner V.M., Jaffe G.J., Stuart A., Kunkel S.L., and Strieter R.M. Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. Curr. Eye Res. 14 (1995) 1045-1053
15. Fredriksson L., Li H., and Eriksson U. The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev. 15 (2004) 197-204
16. Fredriksson L., Li H., Fieber C., Li X., and Eriksson U. Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 23 (2004) 3793-3802
17. Glaser B.M., Cardin A., and Biscoe B. Proliferative vitreoretinopathy: the mechanism of development of vitreoretinal traction. Ophthalmology 94 (1987) 327-332
18. Hinton D.R., He S., Jin M.L., Barron E., and Ryan S.J. Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy. Eye 16 (2002) 422-428
19. Kazlauskas A., and Cooper J.A. Phosphorylation of the PDGF receptor β subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J. 9 (1990) 3266-3279
20. Laqua H., and Machemer R. Glial cell proliferation in retinal detachment (massive periretinal proliferation). Am. J. Ophthalmol. 80 (1975) 602-618
21. LaRochelle W.J., Jeffers M., McDonald W.F., Chillakuru R.A., Giese N.A., Lokker N.A., Sullivan C., Boldog F.L., Yang M., Vernet C., Burgess C.E., Fernandes E., Deegler L.L., Rittman B., Shimkets J., Shimkets R.A., Rothberg J.M., and Lichenstein H.S. PDGF-D, a new protease-activated growth factor. Nat. Cell Biol. 3 (2001) 517-521
22. Lashkari K., Rahimi N., and Kazlauskas A. Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 40 (1999) 149-156
23. Lei H., Hovland P., Velez G., Haran A., Gilbertson D., Hirose T., and Kazlauskas A. A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 48 (2007) 2335-2342
24. Lei H., and Kazlauskas A. Focus on molecules: platelet-derived growth factor C, PDGF-C. Exp. Eye Res. 86 (2008) 711-712
25. Lei H., Velez G., Hovland P., Hirose T., and Kazlauskas A. Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci. 49 (2008) 42-48
26. Leschey K.H., Hackett S.F., Singer J.H., and Campochiaro P.A. Growth factor responsiveness of human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 31 (1990) 839-846
27. Li X., Ponten A., Aase K., Karlsson L., Abramsson A., Uutela M., Backstrom G., Hellstrom M., Bostrom H., Li H., Soriano P., Betsholtz C., Heldin C.H., Alitalo K., Ostman A., and Eriksson U. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. [see comments]. Nat. Cell Biol. 2 (2000) 302-309
28. Liang Y., Li X., Fan J., Zhao M., and Jiang Y. The effect of platelet-derived growth factor on the formation of proliferative vitreoretinopathy. Chung Hua Yen Ko Tsa Chih 38 (2002) 144-147
29. Reigstad L.J., Sande H.M., Fluge O., Bruland O., Muga A., Varhaug J.E., Martinez A., and Lillehaug J.R. Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure. J. Biol. Chem. 278 (2003) 17114-17120
30. Reigstad L.J., Varhaug J.E., and Lillehaug J.R. Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family. FEBS J. 272 (2005) 5723-5741
31. Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.L., Polakiewicz R.D., Rush J., and Comb M.J. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131 (2007) 1190-1203
32. Ryan S.J. Traction retinal detachment XLIX Edward Jackson memorial lecture. Am. J. Ophthalmol. 115 (1993) 1-20
33. Robbins S.G., Mixon R.N., Wilson D.J., Hart C.E., Robertson J.E., Westra I., Planck S.R., and Rosenbaum J.T. Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseases. Invest. Ophthalmol. Vis. Sci. 35 10 (1994) 3649-3663
34. Ustach C.V., and Kim H.R. Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. Mol. Cell. Biol. 25 (2005) 6279-6288
35. Vinores S.A., Henderer J.D., Mahlow J., Chiu C., Derevjanik N.L., LaRochelle W., Csaky C., and Campochiaro P.A. Isoforms of platelet-derived growth factor and its receptors in epiretinal membranes: immunolocalization to retinal pigmented epithelial cells. Exp. Eye Res. 60 (1995) 607-619