The PI3K/Akt pathway mediates the expression of type I collagen induced by TGF-β 2 in human retinal pigment epithelial cells

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 250, Issue 1, 2012, Pages 15-23

  Yokoyama, Katsuhiko ^a   Kimoto, Kenichi ^a   Itoh, Yuji ^b   Nakatsuka, Kazuo ^a   Matsuo, Noritaka ^a   Yoshioka, Hidekatsu ^a   Kubota, Toshiaki ^a  

^a OITA UNIVERSITY   (Japan)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Collagen; PI3K Akt; Retinal pigment epithelium; TGF ; Vitreoretinopathy

Indexed keywords

COLLAGEN TYPE 1; LUCIFERASE; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; WORTMANNIN;

ARTICLE; BINDING SITE; COLLAGEN TYPE 1A1 GENE; COLLAGEN TYPE 1A2 GENE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD7 GENE;

ANDROSTADIENES; BLOTTING, WESTERN; CELLS, CULTURED; COLLAGEN TYPE I; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PLASMIDS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL PIGMENT EPITHELIUM; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84857373600     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-011-1766-x     Document Type: Article

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