Blockade of Jagged/Notch pathway abrogates transforming growth factor β2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells

Current Molecular Medicine

Volumn 14, Issue 4, 2014, Pages 523-534

  Chen, X ^a   Xiao, W ^a   Liu, X ^a   Zeng, M ^a   Luo, L ^a   Wu, M ^a   Ye, S ^a   Liu, Y ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition (EMT); Jagged Notch signaling; Proliferative diabetic retinopathy (PDR); Proliferative vitreoretinopathy (PVR); Retinal pigment epithelium (RPE) cells

Indexed keywords

JAGGED1; NOTCH RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; CALCIUM BINDING PROTEIN; HOMEODOMAIN PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SECRETASE; SERRATE PROTEINS; SIGNAL PEPTIDE; SMAD PROTEIN; SMALL INTERFERING RNA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; ZEB1 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; PIGMENT CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VITREORETINOPATHY; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PIGMENT EPITHELIUM; RNA INTERFERENCE;

AMYLOID PRECURSOR PROTEIN SECRETASES; CALCIUM-BINDING PROTEINS; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, NOTCH; RETINAL PIGMENT EPITHELIUM; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84900416387     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524014666140331230411     Document Type: Article

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