TAZ promotes epithelial to mesenchymal transition via the upregulation of connective tissue growth factor expression in neuroblastoma cells

Molecular Medicine Reports

Volumn 11, Issue 2, 2015, Pages 982-988

  Wang, Qiang ^a   Xu, Zhilin ^a   An, Qun ^a   Jiang, Dapeng ^b   Wang, Long ^a   Liang, Bingxue ^a   Li, Zhaozhu ^b  

^a THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Connective tissue growth factor; Epithelialtomesenchymal transition; Neuroblastoma; TAZ; Transforming growth factor signaling

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; CTGF PROTEIN, HUMAN; MESSENGER RNA; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; TAZ PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; CELL PROLIFERATION; EPIGENETIC REPRESSION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; NEUROBLASTOMA; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CONNECTIVE TISSUE GROWTH FACTOR; EPIGENETIC REPRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; NEUROBLASTOMA; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 84916225043     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2818     Document Type: Article

References (21)

1. Barbieri E, De Preter K, Capasso M, et al: A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. PLoS One 8: e79843, 2013.
2. Bénard J, Raguénez G, Kauffmann A, et al: MYCN-non-amplified metastatic neuroblastoma with good prognosis and spontaneous regression: a molecular portrait of stage 4S. Mol Oncol 2: 261-271, 2008.
3. Couzens AL, Knight JD, Kean MJ, et al: Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal 6: rs15, 2013.
4. Kwon Y, Vinayagam A, Sun X, et al: The Hippo signaling pathway interactome. Science 342: 737-740, 2013.
5. Hao J, Zhang Y, Wang Y, et al: Role of extracellular matrix and YAP/TAZ in cell fate determination. Cell Signal 26: 186-191, 2013.
6. Dupont S, Morsut L, Aragona M, et al: Role of YAP/TAZ in mechanotransduction. Nature 474: 179-183, 2011.
7. Chan SW, Lim CJ, Guo K, et al: A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells. Cancer Res 88: 2592-2598, 2008.
8. Jeong GO, Shin SH, Seo EJ, et al: TAZ mediates lysophosphatidic acid-induced migration and proliferation of epithelial ovarian cancer cells. Cell Physiol Biochem 32: 253-263, 2013.
9. Wang L, Shi S, Guo Z, et al: Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells. PLoS One 8: e65539, 2013.
10. Xie M, Zhang L, He CS, et al: Prognostic significance of TAZ expression in resected non-small cell lung cancer. J Thorac Oncol 7: 799-807, 2012.
11. Bhat KP, Salazar KL, Balasubramaniyan V, et al: The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev 25: 2594-2609, 2011.
12. Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
13. Mikaelian I, Malek M, Gadet R, et al: Genetic and pharmacologic inhibition of mTORC1 promotes EMT by a TGF-β -independent mechanism. Cancer Res 73: 6621-6621, 2013.
14. Sonnylal S, Xu S, Jones H, et al: Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro. J Cell Sci 126: 2164-2175, 2013.
15. Hong JH, Hwang ES, McManus MT, et al: TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309: 1074-1078, 2005.
16. Murakami M, Nakagawa M, Olson EN and Nakagawa O: A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci USA 102: 18034-18039, 2005.
17. Park KS, Whitsett JA, Di Palma T, et al: TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem 279: 17384-17390, 2004.
18. Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype. Nat Rev Cancer 7: 415-428, 2007.
19. Yao D, Dai C and Peng S: Mechanism of the mesenchymal-epithelial transition and its relationship with metastatic tumor formation. Mol Cancer Res 9: 1608-1620, 2011.
20. Tsai JH and Yang J: Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev 27: 2192-2206, 2013.
21. Lei QY, Zhang H, Zhao B, et al: TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 28: 2426-2436, 2008.