Metabolic regulation of kisspeptin

Advances in Experimental Medicine and Biology

Volumn 784, Issue , 2013, Pages 363-383

  Castellano, Juan Manuel ^a   Tena Sempere, Manuel ^a  

^a UNIVERSITY OF CÓRDOBA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; CRCT1 PROTEIN; G PROTEIN COUPLED RECEPTOR 54; GHRELIN; GONADORELIN; GONADOTROPIN; INSULIN; KISSPEPTIN; KISSPEPTIN 10; LEPTIN; LEPTIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MELANIN CONCENTRATING HORMONE; MELANOCORTIN; MESSENGER RNA; NUCLEAR FACTOR Y; PROOPIOMELANOCORTIN; UNCLASSIFIED DRUG;

ARCUATE NUCLEUS; ARTICLE; CELL MATURATION; ENDOCRINE FUNCTION; ENERGY BALANCE; FERTILITY; FOOD INTAKE; GENE; GENE CONTROL; GENE EXPRESSION; GONADOTROPIN RELEASE; GPR54 GENE; HORMONAL REGULATION; HORMONE ACTION; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; KISS1 GENE; METABOLIC REGULATION; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PUBERTY; REPRODUCTION; SIGNAL TRANSDUCTION;

EID: 84934443779     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-6199-9_17     Document Type: Article

References (80)

1. Schwartz NB (2000) Neuroendocrine regulation of reproductive cyclicity. In: Conn PM, Freeman ME (eds) Neuroendocrinology in physiology and medicine, vol. Humana, Totowa, NJ, pp 135-146
2. Tena-Sempere M, Huhtaniemi I (2003) Gonadotropins and gonadotropin receptors. In: Fauser BCJM (ed) Reproductive medicine - molecular, cellular and genetic fundamentals, vol. Partenon Publishing, New York, pp 225-244
3. Fernandez-Fernandez R, Martini AC, Navarro VM, Castellano JM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2006) Novel signals for the integration of energy balance and reproduction. Mol Cell Endocrinol 254-255:127-132
4. Tena-Sempere M (2007) Roles of ghrelin and leptin in the control of reproductive function. Neuroendocrinology 86:229-241
5. Kennedy GC, Mitra J (1963) Body weight and food intake as initiating factors for puberty in the rat. J Physiol 166:408-418
6. Frisch RE, Revelle R (1970) Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 169:397-399
7. Frisch RE, McArthur JW (1974) Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 185:949-951
8. Casanueva FF, Dieguez C (1999) Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol 20:317-363
9. Tena-Sempere M (2008) Ghrelin as a pleotrophic modulator of gonadal function and reproduction. Nat Clin Pract Endocrinol Metab 4:666-674
10. Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2009) KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications. Peptides 30:139-145
11. Roa J, Garcia-Galiano D, Castellano JM, Gaytan F, Pinilla L, Tena-Sempere M (2010) Metabolic control of puberty onset: new players, new mechanisms. Mol Cell Endocrinol 324:87-94
12. True C, Kirigiti MA, Kievit P, Grove KL, Susan Smith M (2011) Leptin is not the critical signal for kisspeptin or luteinising hormone restoration during exit from negative energy balance. J Neuroendocrinol 23:1099-1112
13. Szymanski LA, Schneider JE, Friedman MI, Ji H, Kurose Y, Blache D, Rao A, Dunshea FR, Clarke IJ (2007) Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes. J Neuroendocrinol 19:449-460
14. Cunningham MJ, Clifton DK, Steiner RA (1999) Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 60:216-222
15. Quennell JH, Mulligan AC, Tups A, Liu X, Phipps SJ, Kemp CJ, Herbison AE, Grattan DR, Anderson GM (2009) Leptin indirectly regulates gonadotropin- releasing hormone neuronal function. Endocrinology 150:2805-2812
16. Oakley AE, Clifton DK, Steiner RA (2009) Kisspeptin signaling in the brain. Endocr Rev 30:713-743
17. Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2008) New frontiers in kisspeptin/ GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol 29:48-69
18. Simonneaux V, Ansel L, Revel FG, Klosen P, Pevet P, Mikkelsen JD (2009) Kisspeptin and the seasonal control of reproduction in hamsters. Peptides 30:146-153
19. Tena-Sempere M (2006) KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility. Neuroendocrinology 83:275-281
20. Castellano JM, Navarro VM, Fernandez-Fernandez R, Nogueiras R, Tovar S, Roa J, Vazquez MJ, Vigo E, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M (2005) Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 146:3917-3925
21. Brown RE, Imran SA, Ur E, Wilkinson M (2008) KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake. Mol Cell Endocrinol 281:64-72
22. Matsuzaki T, Iwasa T, Kinouchi R, Yoshida S, Murakami M, Gereltsetseg G, Yamamoto S, Kuwahara A, Yasui T, Irahara M (2011) Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats. Endocr J 58:1003-1012
23. Luque RM, Kineman RD, Tena-Sempere M (2007) Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 148:4601-4611
24. Castellano JM, Navarro VM, Fernandez-Fernandez R, Roa J, Vigo E, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2006) Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 55:2602-2610
25. Castellano JM, Navarro VM, Roa J, Pineda R, Sanchez-Garrido MA, Garcia-Galiano D, Vigo E, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2009) Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 150:784-794
26. Smith JT, Acohido BV, Clifton DK, Steiner RA (2006) KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol 18:298-303
27. Roa J, Garcia-Galiano D, Varela L, Sanchez-Garrido MA, Pineda R, Castellano JM, Ruiz-Pino F, Romero M, Aguilar E, Lopez M, Gaytan F, Dieguez C, Pinilla L, Tena-Sempere M (2009) The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system. Endocrinology 150:5016-5026
28. Kalamatianos T, Grimshaw SE, Poorun R, Hahn JD, Coen CW (2008) Fasting reduces KiSS-1 expression in the anteroventral periventricular nucleus (AVPV): effects of fasting on the expression of KiSS-1 and neuropeptide Y in the AVPV or arcuate nucleus of female rats. J Neuroendocrinol 20:1089-1097
29. True C, Kirigiti M, Ciofi P, Grove KL, Smith MS (2011) Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat. J Neuroendocrinol 23:52-64
30. Backholer K, Smith JT, Rao A, Pereira A, Iqbal J, Ogawa S, Li Q, Clarke IJ (2010) Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. Endocrinology 151:2233-2243
31. Castellano JM, Bentsen AH, Mikkelsen JD, Tena-Sempere M (2010) Kisspeptins: bridging energy homeostasis and reproduction. Brain Res 1364:129-138
32. Castellano JM, Bentsen AH, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, Sanchez- Garrido MA, Pinilla L, Mikkelsen JD, Tena-Sempere M (2010) Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects. Am J Physiol Endocrinol Metab 299:E54-E61
33. Rachon D, Teede H (2010) Ovarian function and obesity - interrelationship, impact on women's reproductive lifespan and treatment options. Mol Cell Endocrinol 316:172-179
34. Biro FM, Wien M (2010) Childhood obesity and adult morbidities. Am J Clin Nutr 91:1499S-1505S
35. Ahmed ML, Ong KK, Dunger DB (2009) Childhood obesity and the timing of puberty. Trends Endocrinol Metab 20:237-242
36. Loret de Mola JR (2009) Obesity and its relationship to infertility in men and women. Obstet Gynecol Clin North Am 36:333-346, ix
37. Garcia-Galiano D, Pinilla L, Tena-Sempere M (2012) Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions. J Neuroendocrinol 24:22-33
38. Quennell JH, Howell CS, Roa J, Augustine RA, Grattan DR, Anderson GM (2011) Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology 152:1541-1550
39. Castellano JM, Bentsen AH, Sanchez-Garrido MA, Ruiz-Pino F, Romero M, Garcia-Galiano D, Aguilar E, Pinilla L, Dieguez C, Mikkelsen JD, Tena-Sempere M (2011) Early metabolic programming of puberty onset: impact of changes in postnatal feeding and rearing conditions on the timing of puberty and development of the hypothalamic kisspeptin system. Endocrinology 152:3396-3408
40. Smith JT, Spencer SJ (2012) Preweaning over- and underfeeding alters onset of puberty in the rat without affecting kisspeptin. Biol Reprod 86(145):141-148
41. George JT, Millar RP, Anderson RA (2010) Hypothesis: kisspeptin mediates male hypogonadism in obesity and type 2 diabetes. Neuroendocrinology 91:302-307
42. Tovar S, Vazquez MJ, Navarro VM, Fernandez-Fernandez R, Castellano JM, Vigo E, Roa J, Casanueva FF, Aguilar E, Pinilla L, Dieguez C, Tena-Sempere M (2006) Effects of single or repeated intravenous administration of kisspeptin upon dynamic LH secretion in conscious male rats. Endocrinology 147:2696-2704
43. Roa J, Vigo E, Garcia-Galiano D, Castellano JM, Navarro VM, Pineda R, Dieguez C, Aguilar E, Pinilla L, Tena-Sempere M (2008) Desensitization of gonadotropin responses to kisspeptin in the female rat: analyses of LH and FSH secretion at different developmental and metabolic states. Am J Physiol Endocrinol Metab 294:E1088-E1096
44. Wahab F, Aziz F, Irfan S, Zaman WU, Shahab M (2008) Short-term fasting attenuates the response of the HPG axis to kisspeptin challenge in the adult male rhesus monkey (Macaca mulatta). Life Sci 83:633-637
45. Hill JW, Elmquist JK, Elias CF (2008) Hypothalamic pathways linking energy balance and reproduction. Am J Physiol Endocrinol Metab 294:E827-E832
46. Cravo RM, Margatho LO, Osborne-Lawrence S, Donato J Jr, Atkin S, Bookout AL, Rovinsky S, Frazao R, Lee CE, Gautron L, Zigman JM, Elias CF (2011) Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 173:37-56
47. Morelli A, Marini M, Mancina R, Luconi M, Vignozzi L, Fibbi B, Filippi S, Pezzatini A, Forti G, Vannelli GB, Maggi M (2008) Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. J Sex Med 5:1097-1113
48. Qiu J, Fang Y, Bosch MA, Ronnekleiv OK, Kelly MJ (2011) Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology 152:1503-1514
49. Donato J Jr, Cravo RM, Frazao R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S Jr, Coppari R, Zigman JM, Elmquist JK, Elias CF (2011) Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest 121:355-368
50. Louis GW, Greenwald-Yarnell M, Phillips R, Coolen LM, Lehman MN, Myers MG Jr (2011) Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology 152:2302-2310
51. Tena-Sempere M, Barreiro ML (2002) Leptin in male reproduction: the testis paradigm. Mol Cell Endocrinol 188:9-13
52. Welt CK (2007) Will leptin become the treatment of choice for functional hypothalamic amenorrhea? Nat Clin Pract Endocrinol Metab 3:556-557
53. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS (2004) Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 351:987-997
54. Chou SH, Chamberland JP, Liu X, Matarese G, Gao C, Stefanakis R, Brinkoetter MT, Gong H, Arampatzi K, Mantzoros CS (2011) Leptin is an effective treatment for hypothalamic amenorrhea. Proc Natl Acad Sci U S A 108:6585-6590
55. Jayasena CN, Nijher GM, Chaudhri OB, Murphy KG, Ranger A, Lim A, Patel D, Mehta A, Todd C, Ramachandran R, Salem V, Stamp GW, Donaldson M, Ghatei MA, Bloom SR, Dhillo WS (2009) Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab 94:4315-4323
56. Donato J Jr, Silva RJ, Sita LV, Lee S, Lee C, Lacchini S, Bittencourt JC, Franci CR, Canteras NS, Elias CF (2009) The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion. J Neurosci 29:5240-5250
57. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471-484
58. Chiang GG, Abraham RT (2007) Targeting the mTOR signaling network in cancer. Trends Mol Med 13:433-442
59. Tsang CK, Qi H, Liu LF, Zheng XF (2007) Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov Today 12:112-124
60. Martin DE, Hall MN (2005) The expanding TOR signaling network. Curr Opin Cell Biol 17:158-166
61. Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253-262
62. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ (2006) Hypothalamic mTOR signaling regulates food intake. Science 312:927-930
63. Woods SC, Seeley RJ, Cota D (2008) Regulation of food intake through hypothalamic signaling networks involving mTOR. Annu Rev Nutr 28:295-311
64. Altarejos JY, Goebel N, Conkright MD, Inoue H, Xie J, Arias CM, Sawchenko PE, Montminy M (2008) The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nat Med 14:1112-1117
65. Breuillaud L, Halfon O, Magistretti PJ, Pralong FP, Cardinaux JR (2009) Mouse fertility is not dependent on the CREB coactivator Crtc1. Nat Med 15:989-990; author reply 991
66. Caron E, Ciofi P, Prevot V, Bouret SG (2012) Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci 32:11486-11494
67. Iwasa T, Matsuzaki T, Murakami M, Fujisawa S, Kinouchi R, Gereltsetseg G, Kuwahara A, Yasui T, Irahara M (2010) Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats. J Physiol 588:821-829
68. Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Fujisawa S, Kuwahara A, Yasui T, Irahara M (2010) Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats. J Endocrinol 207:195-202
69. Fernandez-Fernandez R, Navarro VM, Barreiro ML, Vigo EM, Tovar S, Sirotkin AV, Casanueva FF, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M (2005) Effects of chronic hyperghrelinemia on puberty onset and pregnancy outcome in the rat. Endocrinology 146:3018-3025
70. Kalra SP, Crowley WR (1992) Neuropeptide Y: a novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone. Front Neuroendocrinol 13:1-46
71. Pralong FP (2010) Insulin and NPY pathways and the control of GnRH function and puberty onset. Mol Cell Endocrinol 324:82-86
72. Xu J, Kirigiti MA, Cowley MA, Grove KL, Smith MS (2009) Suppression of basal spontaneous gonadotropin-releasing hormone neuronal activity during lactation: role of inhibitory effects of neuropeptide Y. Endocrinology 150:333-340
73. Kalra SP, Kalra PS (2004) NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy. Neuropeptides 38:201-211
74. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG (1996) Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106
75. Backholer K, Smith J, Clarke IJ (2009) Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. Endocrinology 150:5488-5497
76. Wu M, Dumalska I, Morozova E, van den Pol A, Alreja M (2009) Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proc Natl Acad Sci U S A 106:17217-17222
77. Thompson EL, Patterson M, Murphy KG, Smith KL, Dhillo WS, Todd JF, Ghatei MA, Bloom SR (2004) Central and peripheral administration of kisspeptin-10 stimulates the hypothalamicpituitary- gonadal axis. J Neuroendocrinol 16:850-858
78. Fu LY, van den Pol AN (2010) Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci 30:10205-10219
79. Stengel A, Wang L, Goebel-Stengel M, Tache Y (2011) Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice. Neuroreport 22:253-257
80. Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, Lai J, Ciofi P, McMullen NT, Rance NE (2012) Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology 153:2800-2812