메뉴 건너뛰기




Volumn 91, Issue 4, 2010, Pages 302-307

Hypothesis: Kisspeptin mediates male hypogonadism in obesity and type 2 diabetes

Author keywords

Diabetes; GPR 54; Hypogonadism; KISS1; KISS1R; Kisspeptin; Metabolic syndrome; Metabolism; Obesity; Testosterone

Indexed keywords

AROMATASE INHIBITOR; ESTRADIOL; ESTROGEN; ESTRONE; GONADORELIN; GONADOTROPIN; KISSPEPTIN; LEPTIN; TESTOSTERONE; KISS1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

EID: 77954647851     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000299767     Document Type: Review
Times cited : (100)

References (48)
  • 2
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, Sicree R, King H: Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27: 1047-1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 3
    • 25144459980 scopus 로고    scopus 로고
    • IDF Epidemiology Task Force Consensus Group: The metabolic syndrome - A new worldwide definition
    • Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group: The metabolic syndrome - a new worldwide definition. Lancet 2005; 366: 1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 4
  • 5
    • 0023915573 scopus 로고
    • Effect of massive weight loss on hypothalamic-pituitary- gonadal function in obese men
    • Strain GW, Zumoff B, Miller LK, et al: Effect of massive weight loss on hypothalamic-pituitary- gonadal function in obese men. J Clin Endocrinol Metab 1988; 66: 1019-1023.
    • (1988) J Clin Endocrinol Metab , vol.66 , pp. 1019-1023
    • Strain, G.W.1    Zumoff, B.2    Miller, L.K.3
  • 7
    • 51649115358 scopus 로고    scopus 로고
    • Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups
    • Kupelian V, Hayes FJ, Link CL, Rosen R, McKinlay JB: Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab 2008; 93: 3403-3410.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3403-3410
    • Kupelian, V.1    Hayes, F.J.2    Link, C.L.3    Rosen, R.4    McKinlay, J.B.5
  • 8
    • 33644828241 scopus 로고    scopus 로고
    • Low sex hormone- binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    • Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB: Low sex hormone- binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab 2006; 91: 843-850.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 843-850
    • Kupelian, V.1    Page, S.T.2    Araujo, A.B.3    Travison, T.G.4    Bremner, W.J.5    McKinlay, J.B.6
  • 9
    • 33745684473 scopus 로고    scopus 로고
    • Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes
    • Kapoor D, Goodwin E, Channer KS, Jones TH: Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Endocrinol 2006; 154: 899-906.
    • (2006) Eur J Endocrinol , vol.154 , pp. 899-906
    • Kapoor, D.1    Goodwin, E.2    Channer, K.S.3    Jones, T.H.4
  • 10
    • 3242717140 scopus 로고    scopus 로고
    • Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life
    • Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, et al: Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart 2004; 90: 871-876.
    • (2004) Heart , vol.90 , pp. 871-876
    • Malkin, C.J.1    Pugh, P.J.2    Morris, P.D.3    Kerry, K.E.4    Jones, R.D.5    Jones, T.H.6
  • 12
    • 60149110147 scopus 로고    scopus 로고
    • The role of kisspeptin in the control of gonadotrophin secretion
    • Roseweir AK, Millar RP: The role of kisspeptin in the control of gonadotrophin secretion. Hum Reprod Update 2009; 15: 203-212.
    • (2009) Hum Reprod Update , vol.15 , pp. 203-212
    • Roseweir, A.K.1    Millar, R.P.2
  • 13
    • 0027210856 scopus 로고
    • Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men
    • Vermeulen A, Kaufman J, Deslypere J, Thomas G: Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 1993; 76: 1140-1146.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1140-1146
    • Vermeulen, A.1    Kaufman, J.2    Deslypere, J.3    Thomas, G.4
  • 14
    • 84992719978 scopus 로고    scopus 로고
    • Hypogonadotropic hypogonadism in erectile dysfunction associated with type 2 diabetes mellitus: A common defect?
    • Tripathy D, Dhindsa S, Garg R, Khaishagi A, Syed T, Dandona P: Hypogonadotropic hypogonadism in erectile dysfunction associated with type 2 diabetes mellitus: a common defect? Metab Syndr Relat Disord 2003; 1: 75-80.
    • (2003) Metab Syndr Relat Disord , vol.1 , pp. 75-80
    • Tripathy, D.1    Dhindsa, S.2    Garg, R.3    Khaishagi, A.4    Syed, T.5    Dandona, P.6
  • 15
    • 0029808561 scopus 로고    scopus 로고
    • KiSS-1, a novel human malignant melanoma metastasis- suppressor gene
    • Lee J, Miele ME, Hicks DJ, et al: KiSS-1, a novel human malignant melanoma metastasis- suppressor gene. J Natl Cancer Inst 1996; 88: 1731-1737.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1731-1737
    • Lee, J.1    Miele, M.E.2    Hicks, D.J.3
  • 16
    • 28744448385 scopus 로고    scopus 로고
    • Kisspeptin-54 stimulates the hypothalamicpituitary gonadal axis in human males
    • Dhillo WS, Chaudhri OB, Patterson M, et al: Kisspeptin-54 stimulates the hypothalamicpituitary gonadal axis in human males. J Clin Endocrinol Metab 2005; 90: 6609-6615.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6609-6615
    • Dhillo, W.S.1    Chaudhri, O.B.2    Patterson, M.3
  • 17
    • 33750916941 scopus 로고    scopus 로고
    • KiSS-1 and reproduction: Focus on its role in the metabolic regulation of fertility
    • Tena-Sempere M: KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility. Neuroendocrinology 2006; 83: 275-281.
    • (2006) Neuroendocrinology , vol.83 , pp. 275-281
    • Tena-Sempere, M.1
  • 18
    • 0141814637 scopus 로고    scopus 로고
    • Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
    • de Roux N, Genin E, Carel J, Matsuda F, Chaussain J, Milgrom E: Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 2003; 100: 10972-10976.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10972-10976
    • De Roux, N.1    Genin, E.2    Carel, J.3    Matsuda, F.4    Chaussain, J.5    Milgrom, E.6
  • 19
    • 57849127113 scopus 로고    scopus 로고
    • Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men
    • Chan Y, Broder-Fingert S, Seminara SB: Reproductive functions of kisspeptin and Gpr54 across the life cycle of mice and men. Peptides 2009; 30: 42-48.
    • (2009) Peptides , vol.30 , pp. 42-48
    • Chan, Y.1    Broder-Fingert, S.2    Seminara, S.B.3
  • 21
    • 57849090041 scopus 로고    scopus 로고
    • Transgenic mouse models to study Gpr54/kisspeptin physiology
    • Colledge WH: Transgenic mouse models to study Gpr54/kisspeptin physiology. Peptides 2009; 30: 34-41.
    • (2009) Peptides , vol.30 , pp. 34-41
    • Colledge, W.H.1
  • 23
    • 34447115135 scopus 로고    scopus 로고
    • Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys
    • Rometo AM, Krajewski SJ, Lou Voytko M, Rance NE: Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeys. J Clin Endocrinol Metab 2007; 92: 2744-2750.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2744-2750
    • Rometo, A.M.1    Krajewski, S.J.2    Lou Voytko, M.3    Rance, N.E.4
  • 25
    • 43149085965 scopus 로고    scopus 로고
    • Let rozole once a week normalizes serum testosterone in obesity-related male hypogonadism
    • Loves S, Ruinemans-Koerts J, de Boer H: Let rozole once a week normalizes serum testosterone in obesity-related male hypogonadism. Eur J Endocrinol 2008; 158: 741-747.
    • (2008) Eur J Endocrinol , vol.158 , pp. 741-747
    • Loves, S.1    Ruinemans-Koerts, J.2    De Boer, H.3
  • 26
    • 0032460910 scopus 로고    scopus 로고
    • Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons
    • Herbison AE: Multimodal influence of estrogen upon gonadotropin-releasing hormone neurons. Endocr Rev 1998; 19: 302-330.
    • (1998) Endocr Rev , vol.19 , pp. 302-330
    • Herbison, A.E.1
  • 27
    • 33646232953 scopus 로고    scopus 로고
    • Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling
    • Smith JT, Clifton DK, Steiner RA: Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction 2006; 131: 623-630.
    • (2006) Reproduction , vol.131 , pp. 623-630
    • Smith, J.T.1    Clifton, D.K.2    Steiner, R.A.3
  • 28
    • 4644289298 scopus 로고    scopus 로고
    • Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide
    • Navarro VM, Castellano JM, Fernández- Fernández R, et al: Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 2004; 145: 4565-4574.
    • (2004) Endocrinology , vol.145 , pp. 4565-4574
    • Navarro, V.M.1    Castellano, J.M.2    Fernández-Fernández, R.3
  • 29
    • 33646575920 scopus 로고    scopus 로고
    • Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
    • Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A: Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha. Neurosci Lett 2006; 401: 225-230.
    • (2006) Neurosci Lett , vol.401 , pp. 225-230
    • Franceschini, I.1    Lomet, D.2    Cateau, M.3    Delsol, G.4    Tillet, Y.5    Caraty, A.6
  • 31
    • 61449105725 scopus 로고    scopus 로고
    • Leptin: A pivotal regulator of human energy homeostasis
    • Farooqi IS, O'Rahilly S: Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009; 89: 980S-984S.
    • (2009) Am J Clin Nutr , vol.89
    • Farooqi, I.S.1    O'Rahilly, S.2
  • 32
    • 0033304558 scopus 로고    scopus 로고
    • Leptin and androgens in male obesity: Evidence for leptin contribution to reduced androgen levels
    • Isidori AM, Caprio M, Strollo F, et al: Leptin and androgens in male obesity: evidence for leptin contribution to reduced androgen levels. J Clin Endocrinol Metab 1999; 84: 3673-3680.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3673-3680
    • Isidori, A.M.1    Caprio, M.2    Strollo, F.3
  • 33
    • 55849114349 scopus 로고    scopus 로고
    • Adipocytokines and the metabolic complications of obesity
    • Rasouli N, Kern PA: Adipocytokines and the metabolic complications of obesity. J Clin Endocrinol Metab 2008; 93:S64-S73.
    • (2008) J Clin Endocrinol Metab , vol.93
    • Rasouli, N.1    Kern, P.A.2
  • 36
    • 23844455323 scopus 로고    scopus 로고
    • Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition
    • Castellano JM, Navarro VM, Fernández-Fernández R, et al: Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition. Endocrinology 2005; 146: 3917-3925.
    • (2005) Endocrinology , vol.146 , pp. 3917-3925
    • Castellano, J.M.1    Navarro, V.M.2    Fernández-Fernández, R.3
  • 37
    • 10644284011 scopus 로고    scopus 로고
    • Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54
    • Navarro VM, Fernández-Fernández R, Castellano JM, et al: Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54. J Physiol 2004; 561: 379-386.
    • (2004) J Physiol , vol.561 , pp. 379-386
    • Navarro, V.M.1    Fernández-Fernández, R.2    Castellano, J.M.3
  • 38
    • 33750591860 scopus 로고    scopus 로고
    • Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats
    • Castellano JM, Navarro VM, Fernández-Fernández R, et al: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. Diabetes 2006; 55: 2602-2610.
    • (2006) Diabetes , vol.55 , pp. 2602-2610
    • Castellano, J.M.1    Navarro, V.M.2    Fernández-Fernández, R.3
  • 40
    • 0034703229 scopus 로고    scopus 로고
    • Role of brain insulin receptor in control of body weight and reproduction
    • Bruning JC, Gautam D, Burks DJ, et al: Role of brain insulin receptor in control of body weight and reproduction. Science 2000; 289: 2122-2125.
    • (2000) Science , vol.289 , pp. 2122-2125
    • Bruning, J.C.1    Gautam, D.2    Burks, D.J.3
  • 41
    • 57849148921 scopus 로고    scopus 로고
    • KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications
    • Castellano JM, Roa J, Luque RM, Dieguez C, Aguilar E, Pinilla L, et al: KiSS-1/kisspeptins and the metabolic control of reproduction: physiologic roles and putative physiopathological implications. Peptides 2009; 30: 139-145.
    • (2009) Peptides , vol.30 , pp. 139-145
    • Castellano, J.M.1    Roa, J.2    Luque, R.M.3    Dieguez, C.4    Aguilar, E.5    Pinilla, L.6
  • 43
    • 54949141523 scopus 로고    scopus 로고
    • Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat
    • Iwasa T, Matsuzaki T, Murakami M, et al: Decreased expression of kisspeptin mediates acute immune/inflammatory stress-induced suppression of gonadotropin secretion in female rat. J Endocrinol Invest 2008; 31: 656-659.
    • (2008) J Endocrinol Invest , vol.31 , pp. 656-659
    • Iwasa, T.1    Matsuzaki, T.2    Murakami, M.3
  • 44
    • 0037323459 scopus 로고    scopus 로고
    • Dramatic elevation of plasma metastin concentrations in human pregnancy: Metastin as a novel placenta-derived hormone in humans
    • Horikoshi Y, Matsumoto H, Takatsu Y, et al: Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans. J Clin Endocrinol Metab 2003; 88: 914-919.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 914-919
    • Horikoshi, Y.1    Matsumoto, H.2    Takatsu, Y.3
  • 45
    • 40449126122 scopus 로고    scopus 로고
    • Preanalytical factors affecting RIA measurement of plasma kisspeptin
    • Ramachandran R, Patterson M, Murphy KG, et al: Preanalytical factors affecting RIA measurement of plasma kisspeptin. Clin Chem 2008; 54: 615-617.
    • (2008) Clin Chem , vol.54 , pp. 615-617
    • Ramachandran, R.1    Patterson, M.2    Murphy, K.G.3
  • 46
    • 70449111663 scopus 로고    scopus 로고
    • Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis
    • Jayasena CN, Nijher GMK, Chaudhri OB, et al: Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab 2009; 94: 4315-4323.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4315-4323
    • Jayasena, C.N.1    Nijher, G.M.K.2    Chaudhri, O.B.3
  • 47
    • 64849108752 scopus 로고    scopus 로고
    • Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation
    • Roseweir AK, Kauffman AS, Smith JT, et al: Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci 2009; 29: 3920-3929.
    • (2009) J Neurosci , vol.29 , pp. 3920-3929
    • Roseweir, A.K.1    Kauffman, A.S.2    Smith, J.T.3
  • 48
    • 59649113096 scopus 로고    scopus 로고
    • Alterations in hypothalamic KiSS-1 system in experimental diabetes: Early changes and functional consequences
    • Castellano JM, Navarro VM, Roa J, et al: Alterations in hypothalamic KiSS-1 system in experimental diabetes: early changes and functional consequences. Endocrinology 2009; 150: 784-794.
    • (2009) Endocrinology , vol.150 , pp. 784-794
    • Castellano, J.M.1    Navarro, V.M.2    Roa, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.