메뉴 건너뛰기




Volumn 76, Issue 1, 2015, Pages 1-11

Endometrial cancer: Redefining the molecular-targeted approach

Author keywords

Cancer; Chemotherapy; Endometrial cancer; Endometrium; Molecular targets; Targeted therapy

Indexed keywords

ANGIOGENESIS INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; SMALL MOLECULE TRANSPORT AGENT; UNCLASSIFIED DRUG;

EID: 84934441923     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-015-2758-z     Document Type: Review
Times cited : (17)

References (97)
  • 1
    • 51549117737 scopus 로고    scopus 로고
    • National Cancer Institute; Bethesda, MD based on November 2013 SEER data submission, posted to the SEER web site
    • Ries LAG, Melbert D, Krapcho M et al (2014) SEER cancer statistics review, 1975-2014. National Cancer Institute; Bethesda, MD. http://seer.cancer.gov/statfacts/html/corp.html, based on November 2013 SEER data submission, posted to the SEER web site
    • (2014) SEER Cancer Statistics Review, 1975-2014
    • Ries, L.A.G.1    Melbert, D.2    Krapcho, M.3
  • 2
    • 38749134447 scopus 로고    scopus 로고
    • Novel molecular profiles of endometrial cancer new light through hold windows
    • 1:CAS:528:DC%2BD1cXhsFyntb0%3D 18061438
    • Doll A, Abal M, Rigau M et al (2008) Novel molecular profiles of endometrial cancer new light through hold windows. J Steroid Biochem Mol Biol 108(3-5):221-229
    • (2008) J Steroid Biochem Mol Biol , vol.108 , Issue.3-5 , pp. 221-229
    • Doll, A.1    Abal, M.2    Rigau, M.3
  • 3
    • 0020660717 scopus 로고
    • Two pathogenetic types of endometrial carcinoma
    • 1:STN:280:DyaL3s7gs1KktA%3D%3D 6822361
    • Bokhman JV (1983) Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 15(1):10-17
    • (1983) Gynecol Oncol , vol.15 , Issue.1 , pp. 10-17
    • Bokhman, J.V.1
  • 4
    • 0028829840 scopus 로고
    • Endometrial intraepithelial carcinoma: A distinctive lesion specifically associated with tumors displaying serous differentiation
    • 1:STN:280:DyaK28%2FmvVOruw%3D%3D 7590702
    • Ambros RA, Sherman ME, Zahn CM, Bitterman P, Kurman RJ (1995) Endometrial intraepithelial carcinoma: a distinctive lesion specifically associated with tumors displaying serous differentiation. Hum Pathol 26:1260-1267
    • (1995) Hum Pathol , vol.26 , pp. 1260-1267
    • Ambros, R.A.1    Sherman, M.E.2    Zahn, C.M.3    Bitterman, P.4    Kurman, R.J.5
  • 6
    • 77955919147 scopus 로고    scopus 로고
    • Serum tumour markers in gynaecological cancers
    • 1:CAS:528:DC%2BC3cXhtVaqsb%2FO 20510555
    • Aggarwal P, Kehoe S (2010) Serum tumour markers in gynaecological cancers. Maturitas 67:46-53
    • (2010) Maturitas , vol.67 , pp. 46-53
    • Aggarwal, P.1    Kehoe, S.2
  • 7
    • 33750576103 scopus 로고    scopus 로고
    • Molecular and pathologic aspects of endometrial carcinogenesis
    • 1:CAS:528:DC%2BD28XhtFynsrrO 17028294
    • Hecht Jonathan L, Mutter George L (2006) Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 24(29):4783-4791
    • (2006) J Clin Oncol , vol.24 , Issue.29 , pp. 4783-4791
    • Hecht, J.L.1    Mutter, G.L.2
  • 9
    • 84892992470 scopus 로고    scopus 로고
    • Heinen: Translating mismatch repair mechanism into cancer care
    • Heinen CD (2014) Translating mismatch repair mechanism into cancer care. Curr Drug Targ 15:53-64
    • (2014) Curr Drug Targ , vol.15 , pp. 53-64
    • Christopher, D.1
  • 10
    • 0029883728 scopus 로고    scopus 로고
    • Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma
    • 1:STN:280:DyaK283gvVWnsw%3D%3D 1861548 8623934
    • Caduff RF, Johnston CM, Svoboda-Newman SM, Poy EL, Merajver SD, Frank TS (1996) Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma. Am J Pathol 148:1671-1678
    • (1996) Am J Pathol , vol.148 , pp. 1671-1678
    • Caduff, R.F.1    Johnston, C.M.2    Svoboda-Newman, S.M.3    Poy, E.L.4    Merajver, S.D.5    Frank, T.S.6
  • 11
    • 0032487831 scopus 로고    scopus 로고
    • MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas
    • 1:CAS:528:DyaK1cXns12mtr4%3D 9811473
    • Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG (1998) MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 17:2413-2417
    • (1998) Oncogene , vol.17 , pp. 2413-2417
    • Esteller, M.1    Levine, R.2    Baylin, S.B.3    Ellenson, L.H.4    Herman, J.G.5
  • 12
    • 0031823235 scopus 로고    scopus 로고
    • Analysis of MSH3 in endometrial cancers with defective DNA mismatch repair
    • 1:CAS:528:DyaK1cXlsFWrtrg%3D 9699180
    • Swisher EM, Mutch DG, Herzog TJ et al (1998) Analysis of MSH3 in endometrial cancers with defective DNA mismatch repair. J Soc Gynecol Investig 5:210-216
    • (1998) J Soc Gynecol Investig , vol.5 , pp. 210-216
    • Swisher, E.M.1    Mutch, D.G.2    Herzog, T.J.3
  • 13
    • 33745450851 scopus 로고    scopus 로고
    • The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer
    • 1:CAS:528:DC%2BD28Xmtlyjs74%3D 16506206
    • Bilbao C, Rodrlguez G, Ramlrez R, Falcon O, Leon L, Chirino R, Rivero JF et al (2006) The relationship between microsatellite instability and PTEN gene mutations in endometrial cancer. Int J Cancer 119:563-570
    • (2006) Int J Cancer , vol.119 , pp. 563-570
    • Bilbao, C.1    Rodrlguez, G.2    Ramlrez, R.3    Falcon, O.4    Leon, L.5    Chirino, R.6    Rivero, J.F.7
  • 14
    • 0033774009 scopus 로고    scopus 로고
    • Absence of PTEN repeat tract mutation in endome- microsatellite instability
    • 1:CAS:528:DC%2BD3cXmslKns7w%3D 11006040
    • Cohn DE, Basil JB, Venegoni AR et al (2000) Absence of PTEN repeat tract mutation in endome- microsatellite instability. Gynecol Oncol 79:101-106
    • (2000) Gynecol Oncol , vol.79 , pp. 101-106
    • Cohn, D.E.1    Basil, J.B.2    Venegoni, A.R.3
  • 15
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • 1:CAS:528:DyaK3sXks12hu7c%3D 8505985
    • Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363:558-561
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 16
    • 0033083214 scopus 로고    scopus 로고
    • Microsatellite instability impact on cancer progression in proximal and distal colorectal cancers
    • 1:STN:280:DyaK1Mznslelug%3D%3D 10448259
    • Jernvall P, Makinen MJ, Karttunen TJ, Makela J, Vihko P (1999) Microsatellite instability impact on cancer progression in proximal and distal colorectal cancers. Eur J Cancer 35:197-201
    • (1999) Eur J Cancer , vol.35 , pp. 197-201
    • Jernvall, P.1    Makinen, M.J.2    Karttunen, T.J.3    Makela, J.4    Vihko, P.5
  • 17
    • 0032815220 scopus 로고    scopus 로고
    • Replication error in colorectal carcinoma: Association with loss of heterozygosity at mismatch repair loci and clinicopathological variables
    • 1:STN:280:DyaK1MzpvFWjtQ%3D%3D 10470121
    • Johannsdottir JT, Bergthorsson JT, Gretarsdottir S, Kristjans-son AK, Ragnarsson G, Jonasson JG et al (1999) Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. Anticancer Res 19:1821-1826
    • (1999) Anticancer Res , vol.19 , pp. 1821-1826
    • Johannsdottir, J.T.1    Bergthorsson, J.T.2    Gretarsdottir, S.3    Kristjans-Son, A.K.4    Ragnarsson, G.5    Jonasson, J.G.6
  • 18
    • 0031690464 scopus 로고    scopus 로고
    • Microsatellite instability in endometrial carcinomas: Clinicopathologic correlations in a series of 42 cases
    • 1:CAS:528:DyaK1cXntFGgsbY%3D 9781658
    • Catasus L, Machin P, Matias-Guiu X, Prat J (1998) Microsatellite instability in endometrial carcinomas: clinicopathologic correlations in a series of 42 cases. Hum Path 29:1160-1164
    • (1998) Hum Path , vol.29 , pp. 1160-1164
    • Catasus, L.1    Machin, P.2    Matias-Guiu, X.3    Prat, J.4
  • 19
    • 84870532408 scopus 로고    scopus 로고
    • Randomized phase III noninferiority trial of first line chemotherapy for metastatic or recurrent endometrial carcinoma: A gynecologic oncology group study
    • Miller D, Filiaci V, Fleming G et al (2012) Randomized phase III noninferiority trial of first line chemotherapy for metastatic or recurrent endometrial carcinoma: a gynecologic oncology group study. Gynecol Oncol 125:771-773
    • (2012) Gynecol Oncol , vol.125 , pp. 771-773
    • Miller, D.1    Filiaci, V.2    Fleming, G.3
  • 20
    • 0034978311 scopus 로고    scopus 로고
    • PTEN, a protean tumor suppressor
    • 1:CAS:528:DC%2BD3MXkvFyks7c%3D 1891981 11395362
    • Mutter GL (2001) PTEN, a protean tumor suppressor. Am J Pathol 158:1895-1898
    • (2001) Am J Pathol , vol.158 , pp. 1895-1898
    • Mutter, G.L.1
  • 21
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter GL, Lin MC et al (2000) Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Nat Can Inst 92:11
    • (2000) J Nat Can Inst , vol.92 , pp. 11
    • Mutter, G.L.1    Lin, M.C.2
  • 22
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
    • 1:CAS:528:DyaK2sXmtFehs7g%3D 9307275
    • Tashiro H, Blazes MS, Wu R, Cho KR, Bose S, Wang SI et al (1997) Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 57:3935-3940
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3    Cho, K.R.4    Bose, S.5    Wang, S.I.6
  • 23
    • 0030781053 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in endometrial cancers
    • 1:CAS:528:DyaK2sXnt12gurg%3D 9354433
    • Risinger JI, Hayes AK, Berchuck A, Barrett JC (1997) PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57:4736-4738
    • (1997) Cancer Res , vol.57 , pp. 4736-4738
    • Risinger, J.I.1    Hayes, A.K.2    Berchuck, A.3    Barrett, J.C.4
  • 24
    • 84893821223 scopus 로고    scopus 로고
    • Molecular Alterations of PI3K/Akt/mTOR pathway: A therapeutic target in endometrial cancer
    • Art id 709736
    • Pavlidou A, Vlahos NF (2014) Molecular Alterations of PI3K/Akt/mTOR pathway: a therapeutic target in endometrial cancer. Sci World J, Art id 709736
    • (2014) Sci World J
    • Pavlidou, A.1    Vlahos, N.F.2
  • 25
    • 79958820962 scopus 로고    scopus 로고
    • PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer
    • 1:CAS:528:DC%2BC3MXnsFKiu7w%3D
    • Urick ME, Rudd ML, Godwin AK, Sgroi D, Merino M, Bell DW (2011) PIK3R1 (p85a) is somatically mutated at high frequency in primary endometrial cancer. Can Resear 71(12):4061-4067
    • (2011) Can Resear , vol.71 , Issue.12 , pp. 4061-4067
    • Urick, M.E.1    Rudd, M.L.2    Godwin, A.K.3    Sgroi, D.4    Merino, M.5    Bell, D.W.6
  • 26
    • 80054778946 scopus 로고    scopus 로고
    • High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability
    • Cheung LW et al (2011) High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov 2:170-185
    • (2011) Cancer Discov , vol.2 , pp. 170-185
    • Cheung, L.W.1
  • 27
    • 78649592049 scopus 로고    scopus 로고
    • A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
    • 1:CAS:528:DC%2BC3cXhs1WnurzK 20681032
    • Slomovitz BM, Lu KH, Johnston T et al (2010) A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma. Cancer 116(23):5415-5419
    • (2010) Cancer , vol.116 , Issue.23 , pp. 5415-5419
    • Slomovitz, B.M.1    Lu, K.H.2    Johnston, T.3
  • 28
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • 1:CAS:528:DC%2BD38XlvV2htr4%3D 12150925
    • Kim DH, Sarbassov DD, Ali SM et al (2002) mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110(2):163-175
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 29
    • 67649868092 scopus 로고    scopus 로고
    • The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas
    • 1:CAS:528:DC%2BD1MXotVKgur4%3D 2713716 19491896
    • Shoji K, Oda K, Nakagawa S et al (2009) The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas. Br J Cancer 101(1):145-148
    • (2009) Br J Cancer , vol.101 , Issue.1 , pp. 145-148
    • Shoji, K.1    Oda, K.2    Nakagawa, S.3
  • 30
    • 0032953788 scopus 로고    scopus 로고
    • Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability
    • 1:CAS:528:DyaK1MXmsVemsA%3D%3D 9921983
    • Swisher EM, Peiffer-Schneider S, Mutch DG et al (1999) Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability. Cancer 85:119-126
    • (1999) Cancer , vol.85 , pp. 119-126
    • Swisher, E.M.1    Peiffer-Schneider, S.2    Mutch, D.G.3
  • 31
    • 0034651530 scopus 로고    scopus 로고
    • The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: Evidence of distinct molecular genetic pathways
    • 1:CAS:528:DC%2BD3cXhtlGntbk%3D 10679651
    • Lax SF, Kendall B, Tashiro H et al (2000) The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways. Cancer 88:814-824
    • (2000) Cancer , vol.88 , pp. 814-824
    • Lax, S.F.1    Kendall, B.2    Tashiro, H.3
  • 32
    • 0035150494 scopus 로고    scopus 로고
    • K-ras mutations in endometrial carcinomas with microsatellite instability
    • 1:CAS:528:DC%2BD3MXhtFGqtbo%3D 11180166
    • Lagarda H et al (2001) K-ras mutations in endometrial carcinomas with microsatellite instability. J Path 193(2):193-199
    • (2001) J Path , vol.193 , Issue.2 , pp. 193-199
    • Lagarda, H.1
  • 33
    • 0030978351 scopus 로고    scopus 로고
    • Beta-catenin is a target for the ubiquitin-proteasome pathway
    • 1:CAS:528:DyaK2sXkslShsbk%3D 1170003 9233789
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16(13):3797-3804
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 34
    • 0031984835 scopus 로고    scopus 로고
    • Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: Correlation with disease progression and dedifferentiation
    • 1:CAS:528:DyaK1cXktlyntw%3D%3D 1858126 9422531
    • Bailey T, Biddlestone L, Shepherd N, Barr H, Warner P, Jankowski J (1998) Altered cadherin and catenin complexes in the Barrett's esophagus-dysplasia-adenocarcinoma sequence: correlation with disease progression and dedifferentiation. Am J Pathol 152(1):135-144
    • (1998) Am J Pathol , vol.152 , Issue.1 , pp. 135-144
    • Bailey, T.1    Biddlestone, L.2    Shepherd, N.3    Barr, H.4    Warner, P.5    Jankowski, J.6
  • 35
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    • 9554852
    • Wirtz R, Kuhl M, Wedlich D, Birchmeier W (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280:596-599
    • (1998) Science , vol.280 , pp. 596-599
    • Wirtz, R.1    Kuhl, M.2    Wedlich, D.3    Birchmeier, W.4
  • 36
    • 0036957026 scopus 로고    scopus 로고
    • Expression of E-cadherin and alpha-, beta-, gamma-catenin proteins in endometrial carcinoma
    • 1:CAS:528:DC%2BD3sXot1Clsg%3D%3D 12497652
    • Kim YT, Choi EK, Kim JW et al (2002) Expression of E-cadherin and alpha-, beta-, gamma-catenin proteins in endometrial carcinoma. Yonsei Med J 43:701-711
    • (2002) Yonsei Med J , vol.43 , pp. 701-711
    • Kim, Y.T.1    Choi, E.K.2    Kim, J.W.3
  • 37
    • 14944385644 scopus 로고    scopus 로고
    • Immunohistochemical expression of E-cadherin and beta-catenin in the normal and malignant human endometrium: An inverse correlation between E-cadherin and nuclear beta-catenin expression
    • 1:CAS:528:DC%2BD2MXitFylsLg%3D 15736420
    • Shih HC, Shiozawa T, Miyamoto T et al (2004) Immunohistochemical expression of E-cadherin and beta-catenin in the normal and malignant human endometrium: an inverse correlation between E-cadherin and nuclear beta-catenin expression. Anticancer Res 24:3843-3850
    • (2004) Anticancer Res , vol.24 , pp. 3843-3850
    • Shih, H.C.1    Shiozawa, T.2    Miyamoto, T.3
  • 38
    • 0033545845 scopus 로고    scopus 로고
    • The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
    • 1:CAS:528:DyaK1MXjtFCnsbc%3D 21892 10318916
    • Shtutman M, Zhurinsky J, Simcha I et al (1999) The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci USA 96:5522-5527
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5522-5527
    • Shtutman, M.1    Zhurinsky, J.2    Simcha, I.3
  • 39
    • 0037344863 scopus 로고    scopus 로고
    • Molecular genetics and endometrial cancer
    • Oehler MK, Brand A, Wain GV (2003) Molecular genetics and endometrial cancer. J Br Menopause 3:27-31
    • (2003) J Br Menopause , vol.3 , pp. 27-31
    • Oehler, M.K.1    Brand, A.2    Wain, G.V.3
  • 40
    • 48749094526 scopus 로고    scopus 로고
    • Cancer genomics and genetics of FGFR2 (Review)
    • 1:CAS:528:DC%2BD1cXhtV2lsbzP 18636142
    • Katoh M (2008) Cancer genomics and genetics of FGFR2 (Review). Int J Oncol 33:233-237
    • (2008) Int J Oncol , vol.33 , pp. 233-237
    • Katoh, M.1
  • 41
    • 52049086201 scopus 로고    scopus 로고
    • Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
    • 1:CAS:528:DC%2BD1cXhtVCrs7%2FO 18757403
    • Byron SA, Gartside MG, Wellens CL et al (2008) Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation. Cancer Res 68:6902
    • (2008) Cancer Res , vol.68 , pp. 6902
    • Byron, S.A.1    Gartside, M.G.2    Wellens, C.L.3
  • 42
    • 47249122523 scopus 로고    scopus 로고
    • Drug-sensitive FGFR2 mutations in endometrial carcinoma
    • 1:CAS:528:DC%2BD1cXot1agtLw%3D 2438391 18552176
    • Dutt A, Salvesen HB, Chen TH et al (2008) Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci USA 105:8713
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8713
    • Dutt, A.1    Salvesen, H.B.2    Chen, T.H.3
  • 43
    • 80455164694 scopus 로고    scopus 로고
    • FGFR2 alterations in endometrial carcinoma
    • 1:CAS:528:DC%2BC3MXhsVagt77M
    • Gatius S, Velasco A, Azueta A, Santacana M et al (2011) FGFR2 alterations in endometrial carcinoma. Modern Path 24:1500-1510
    • (2011) Modern Path , vol.24 , pp. 1500-1510
    • Gatius, S.1    Velasco, A.2    Azueta, A.3    Santacana, M.4
  • 44
    • 4544379915 scopus 로고    scopus 로고
    • Molecular differences between RER + and RER- sporadic endometrial carcinomas in a large population-based series
    • 1:STN:280:DC%2BD2cvlt1Kktw%3D%3D 15361209
    • Macdonald ND, Salvesen HB, Ryan A, Malatos S, Stefansson I, Iversen OE et al (2004) Molecular differences between RER + and RER- sporadic endometrial carcinomas in a large population-based series. Int J Gynecol Cancer 14:957-965
    • (2004) Int J Gynecol Cancer , vol.14 , pp. 957-965
    • Macdonald, N.D.1    Salvesen, H.B.2    Ryan, A.3    Malatos, S.4    Stefansson, I.5    Iversen, O.E.6
  • 45
    • 0344241483 scopus 로고    scopus 로고
    • Promoter hypermethylation as an epigenetic component in Type i and Type II endometrial cancers
    • 1:CAS:528:DC%2BD3sXjt1yrsLk%3D 12724225
    • Risinger JI, Maxwell GL, Berchuck A, Barrett JC (2003) Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancers. Ann N Y Acad Sci 983:208-212
    • (2003) Ann N y Acad Sci , vol.983 , pp. 208-212
    • Risinger, J.I.1    Maxwell, G.L.2    Berchuck, A.3    Barrett, J.C.4
  • 47
    • 0028889465 scopus 로고
    • Amplification and overexpression of HER-2/neu (c-erbB2) in endome- trial cancers: Correlation with overall survival
    • 1:CAS:528:DyaK2MXps1Krurc%3D 7585656
    • Saffari B, Jones LA, El-Naggar A, Felix JC, George J, Press MF (1995) Amplification and overexpression of HER-2/neu (c-erbB2) in endome- trial cancers: correlation with overall survival. Cancer Res 55:5693-5698
    • (1995) Cancer Res , vol.55 , pp. 5693-5698
    • Saffari, B.1    Jones, L.A.2    El-Naggar, A.3    Felix, J.C.4    George, J.5    Press, M.F.6
  • 48
    • 0028032493 scopus 로고
    • The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer
    • 1:STN:280:DyaK2M%2FmvF2hsQ%3D%3D 7979205
    • Vasen HF, Watson P, Mecklin JP et al (1994) The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer. Anticancer Res 14:1675-1678
    • (1994) Anticancer Res , vol.14 , pp. 1675-1678
    • Vasen, H.F.1    Watson, P.2    Mecklin, J.P.3
  • 49
    • 0030882381 scopus 로고    scopus 로고
    • Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study
    • The International Collaborative Group on HNPCC 1:CAS:528:DyaK2sXmslOlsLg%3D 9322509
    • Peltomaki P, Vasen HF, The International Collaborative Group on HNPCC (1997) Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. Gastroenterology 113:1146-1158
    • (1997) Gastroenterology , vol.113 , pp. 1146-1158
    • Peltomaki, P.1    Vasen, H.F.2
  • 50
    • 0032759135 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization analysis of HER-2/neu, c-myc, and p53 in endometrial cancer
    • 1:CAS:528:DyaK1MXnvFaqsbw%3D 10600396
    • Williams JA Jr, Wang ZR, Parrish RS, Hazlett LJ, Smith ST, Young SR (1999) Fluorescence in situ hybridization analysis of HER-2/neu, c-myc, and p53 in endometrial cancer. Exp Mol Pathol 67:135-143
    • (1999) Exp Mol Pathol , vol.67 , pp. 135-143
    • Williams, Jr.J.A.1    Wang, Z.R.2    Parrish, R.S.3    Hazlett, L.J.4    Smith, S.T.5    Young, S.R.6
  • 52
    • 0031278322 scopus 로고    scopus 로고
    • Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
    • 1:CAS:528:DyaK2sXntVShtbg%3D 9354786
    • Miyaki M, Konishi M, Tanaka K et al (1997) Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer. Nat Genet 17:271-272
    • (1997) Nat Genet , vol.17 , pp. 271-272
    • Miyaki, M.1    Konishi, M.2    Tanaka, K.3
  • 53
    • 0035300475 scopus 로고    scopus 로고
    • Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer
    • 1:CAS:528:DC%2BD3MXivFGrur0%3D 11306449
    • Schweizer P, Moisio AL, Kuismanen SA et al (2001) Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer. Cancer Res 61:2813-2815
    • (2001) Cancer Res , vol.61 , pp. 2813-2815
    • Schweizer, P.1    Moisio, A.L.2    Kuismanen, S.A.3
  • 54
    • 84988273336 scopus 로고    scopus 로고
    • Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: Association with family history and histopathology
    • 1:CAS:528:DC%2BD3cXitVegt7k%3D 10728595
    • Parc YR, Halling KC, Burgart LJ et al (2000) Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: association with family history and histopathology. Int J Cancer 86:60-66
    • (2000) Int J Cancer , vol.86 , pp. 60-66
    • Parc, Y.R.1    Halling, K.C.2    Burgart, L.J.3
  • 55
    • 0033645557 scopus 로고    scopus 로고
    • Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumors from HNPCC patients
    • 11054716
    • De Leeuw WJ, Dierssen J, Vasen HF et al (2000) Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumors from HNPCC patients. J Pathol 192:328-335
    • (2000) J Pathol , vol.192 , pp. 328-335
    • De Leeuw, W.J.1    Dierssen, J.2    Vasen, H.F.3
  • 56
    • 0031893552 scopus 로고    scopus 로고
    • Familial endometrial adenocarcinoma
    • 1:STN:280:DyaK1c7msV2qtg%3D%3D 9504234
    • Sandles LG (1998) Familial endometrial adenocarcinoma. Clin Obstet Gynecol 41:167-171
    • (1998) Clin Obstet Gynecol , vol.41 , pp. 167-171
    • Sandles, L.G.1
  • 57
    • 23044501891 scopus 로고    scopus 로고
    • Molecular analysis of familial endometrial carcinoma: A manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome?
    • 1:CAS:528:DC%2BD2MXotFarsrs%3D 15837969
    • Ollikainen M, Abdel-Rahman WM, Moisio AL et al (2005) Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol 23:4609-4616
    • (2005) J Clin Oncol , vol.23 , pp. 4609-4616
    • Ollikainen, M.1    Abdel-Rahman, W.M.2    Moisio, A.L.3
  • 58
    • 79957949444 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: A gynecologic oncology group study
    • 1:CAS:528:DC%2BC3MXptVOkt7c%3D 3107744 21537039
    • Aghajanian C, Sill MW, Darcy KM et al (2011) Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: a gynecologic oncology group study. J Clin Oncol 29:2259-2265
    • (2011) J Clin Oncol , vol.29 , pp. 2259-2265
    • Aghajanian, C.1    Sill, M.W.2    Darcy, K.M.3
  • 60
    • 84868588283 scopus 로고    scopus 로고
    • A phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: A gynecologic oncology group study
    • 1:CAS:528:DC%2BC38XhtlSnsr7I 3568489 22922531
    • Coleman RL, Sill MW, Lankes HA et al (2012) A phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: a gynecologic oncology group study. Gynecol Oncol 127:538-543
    • (2012) Gynecol Oncol , vol.127 , pp. 538-543
    • Coleman, R.L.1    Sill, M.W.2    Lankes, H.A.3
  • 61
    • 34247128217 scopus 로고    scopus 로고
    • A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: A gynecologic oncology group study
    • 1:CAS:528:DC%2BD2sXksVOms74%3D 1931832 17306350
    • McMeekin DS, Sill MW, Benbrook D et al (2007) A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: a gynecologic oncology group study. Gynecol Oncol 105:508-516
    • (2007) Gynecol Oncol , vol.105 , pp. 508-516
    • McMeekin, D.S.1    Sill, M.W.2    Benbrook, D.3
  • 62
    • 84905568519 scopus 로고    scopus 로고
    • A phase II trial of sunitinib in women with metastatic or recurrent endometrial carcinoma: A study of the Princess Margaret, Chicago and California Consortia
    • 1:CAS:528:DC%2BC2cXhtVaisL%2FL 24882554
    • Castonguay V, Lheureux S, Welch S, Mackay HJ et al (2014) A phase II trial of sunitinib in women with metastatic or recurrent endometrial carcinoma: a study of the Princess Margaret, Chicago and California Consortia. Gynecol Oncol 134:274-280
    • (2014) Gynecol Oncol , vol.134 , pp. 274-280
    • Castonguay, V.1    Lheureux, S.2    Welch, S.3    Mackay, H.J.4
  • 63
    • 52049125733 scopus 로고    scopus 로고
    • Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC-148
    • 1:CAS:528:DC%2BD1cXhtF2it7fN 18591547
    • Oza AM, Eisenhauer EA, Elit L, Cutz JC, Sakurada A et al (2008) Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC-148. J Clin Oncol 26:4319-4432
    • (2008) J Clin Oncol , vol.26 , pp. 4319-4432
    • Oza, A.M.1    Eisenhauer, E.A.2    Elit, L.3    Cutz, J.C.4    Sakurada, A.5
  • 64
    • 74249102857 scopus 로고    scopus 로고
    • Efficacy and safety of gefitinib and potential prognostic value of soluble EGFR, EGFR mutations, and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer
    • Leslie KK, Sill MW, Darcy KM et al (2009) Efficacy and safety of gefitinib and potential prognostic value of soluble EGFR, EGFR mutations, and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer. J Clin Oncol 27:e16542
    • (2009) J Clin Oncol , vol.27 , pp. e16542
    • Leslie, K.K.1    Sill, M.W.2    Darcy, K.M.3
  • 65
    • 46749152126 scopus 로고    scopus 로고
    • Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu
    • 1:CAS:528:DC%2BD1cXosVyiu7Y%3D 18555254
    • Santin AD, Bellone S, Roman JJ, McKenney JK, Pecorelli S (2008) Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu. Int J Gynaecol Obstet 102(2):128-131
    • (2008) Int J Gynaecol Obstet , vol.102 , Issue.2 , pp. 128-131
    • Santin, A.D.1    Bellone, S.2    Roman, J.J.3    McKenney, J.K.4    Pecorelli, S.5
  • 66
    • 33745100721 scopus 로고    scopus 로고
    • Use of trastuzumab in the treatment of metastatic endometrial cancer
    • 1:STN:280:DC%2BD28zoslemsw%3D%3D 16803532
    • Jewell E, Secord AA, Brotherton T, Berchuck A (2006) Use of trastuzumab in the treatment of metastatic endometrial cancer. Int J Gynecol Cancer 16(3):1370-1373
    • (2006) Int J Gynecol Cancer , vol.16 , Issue.3 , pp. 1370-1373
    • Jewell, E.1    Secord, A.A.2    Brotherton, T.3    Berchuck, A.4
  • 67
    • 33749144509 scopus 로고    scopus 로고
    • HER-2/neu overexpression in uterine papillary serous cancers and its possible therapeutic implications
    • 1:STN:280:DC%2BD28rotFKgtA%3D%3D 17009989
    • Villella JA, Cohen S, Smith DH, Hibshoosh H, Hershman D (2006) HER-2/neu overexpression in uterine papillary serous cancers and its possible therapeutic implications. Int J Gynecol Cancer 16(5):1897-1902
    • (2006) Int J Gynecol Cancer , vol.16 , Issue.5 , pp. 1897-1902
    • Villella, J.A.1    Cohen, S.2    Smith, D.H.3    Hibshoosh, H.4    Hershman, D.5
  • 68
    • 70749097152 scopus 로고    scopus 로고
    • Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: A Gynecologic Oncology Group study
    • 1:CAS:528:DC%2BD1MXhsFahsbbE 2804260 19840887
    • Fleming GF, Sill MW, Darcy KM, McMeekin DS, Thigpen JT, Adler LM et al (2010) Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 116(1):15-20
    • (2010) Gynecol Oncol , vol.116 , Issue.1 , pp. 15-20
    • Fleming, G.F.1    Sill, M.W.2    Darcy, K.M.3    McMeekin, D.S.4    Thigpen, J.T.5    Adler, L.M.6
  • 69
    • 74249095141 scopus 로고    scopus 로고
    • In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma
    • 1:CAS:528:DC%2BC3cXhtFOrtg%3D%3D 2813756 19920829
    • El-Sahwi K, Bellone S, Cocco E, Cargnelutti M, Casagrande F, Bellone M et al (2010) In vitro activity of pertuzumab in combination with trastuzumab in uterine serous papillary adenocarcinoma. Br J Cancer 102(1):134-143
    • (2010) Br J Cancer , vol.102 , Issue.1 , pp. 134-143
    • El-Sahwi, K.1    Bellone, S.2    Cocco, E.3    Cargnelutti, M.4    Casagrande, F.5    Bellone, M.6
  • 70
    • 84867402557 scopus 로고    scopus 로고
    • Lapatinib and potential prognostic value of EGFR mutations in a Gynecologic Oncology Groupphase II trial of persistent or recurrent endometrial cancer
    • 1:CAS:528:DC%2BC38XhtlSntr3F 3518448 22885469
    • Leslie KK, Sill MW, Lankes HA, Fischer EG, Godwin AK, Gray H et al (2012) Lapatinib and potential prognostic value of EGFR mutations in a Gynecologic Oncology Groupphase II trial of persistent or recurrent endometrial cancer. Gynecol Oncol 127(2):345-350
    • (2012) Gynecol Oncol , vol.127 , Issue.2 , pp. 345-350
    • Leslie, K.K.1    Sill, M.W.2    Lankes, H.A.3    Fischer, E.G.4    Godwin, A.K.5    Gray, H.6
  • 71
    • 84907977042 scopus 로고    scopus 로고
    • Neratinib shows efficacy in the treatment of HER2/neu amplified uterine serous carcinoma in vitro and in vivo
    • 1:CAS:528:DC%2BC2cXhtlKrsLvE
    • Schwab CL, English DP, Roque DM, Bellone S et al (2014) Neratinib shows efficacy in the treatment of HER2/neu amplified uterine serous carcinoma in vitro and in vivo. Gynec Oncol 135:142-148
    • (2014) Gynec Oncol , vol.135 , pp. 142-148
    • Schwab, C.L.1    English, D.P.2    Roque, D.M.3    Bellone, S.4
  • 72
    • 51849155119 scopus 로고    scopus 로고
    • A phase II study of temsirolimus (CCI-779) in patients with metastatic and/or locally advanced recurrent endometrial cancer previously treated with chemotherapy: NCIC CTG IND 160 b
    • Oza AM, Elit L, Provencher D et al (2008) A phase II study of temsirolimus (CCI-779) in patients with metastatic and/or locally advanced recurrent endometrial cancer previously treated with chemotherapy: NCIC CTG IND 160 b. J Clin Oncol 26:e5516
    • (2008) J Clin Oncol , vol.26 , pp. e5516
    • Oza, A.M.1    Elit, L.2    Provencher, D.3
  • 73
    • 84886027192 scopus 로고    scopus 로고
    • Clinical and toxicity predictors of response and progression to temsirolimus in women with recurrent or metastatic endometrial cancer
    • Rachel RA, Jamal R, Tu D, Walsh W, Dancey J et al (2013) Clinical and toxicity predictors of response and progression to temsirolimus in women with recurrent or metastatic endometrial cancer. Gynec Oncol 131:315-320
    • (2013) Gynec Oncol , vol.131 , pp. 315-320
    • Rachel, R.A.1    Jamal, R.2    Tu, D.3    Walsh, W.4    Dancey, J.5
  • 74
    • 84875539239 scopus 로고    scopus 로고
    • Phase II trial of combination bevacizumab and temsirolimus in the treatment of recurrent or persistent endometrial carcinoma: A gynecologic oncology group study
    • 1:CAS:528:DC%2BC3sXhsV2isLY%3D 23262204
    • Alvarez EA, Brady WE, Walker JL, Rotmensch J, Zhou XC, Kendrick JE (2013) Phase II trial of combination bevacizumab and temsirolimus in the treatment of recurrent or persistent endometrial carcinoma: a gynecologic oncology group study. Gynecol Oncol 129:22-27
    • (2013) Gynecol Oncol , vol.129 , pp. 22-27
    • Alvarez, E.A.1    Brady, W.E.2    Walker, J.L.3    Rotmensch, J.4    Zhou, X.C.5    Kendrick, J.E.6
  • 75
    • 84919477496 scopus 로고    scopus 로고
    • Temsirolimus and pegylated liposomal doxorubicin (PLD) combination therapy in breast, endometrial, and ovarian cancer: Phase Ib results and prediction of clinical outcome with FDG-PET/CT
    • 24577626
    • Boers-Sonderen MJ, Geus-Oei LF, Desar IME, Van der Graaf WTA, Oyen WJG (2014) Temsirolimus and pegylated liposomal doxorubicin (PLD) combination therapy in breast, endometrial, and ovarian cancer: phase Ib results and prediction of clinical outcome with FDG-PET/CT. Target Oncol 9(4):339-347
    • (2014) Target Oncol , vol.9 , Issue.4 , pp. 339-347
    • Boers-Sonderen, M.J.1    Geus-Oei, L.F.2    Desar, I.M.E.3    Van Der Graaf, W.T.A.4    Oyen, W.J.G.5
  • 76
    • 84896393304 scopus 로고    scopus 로고
    • Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: A gynecologic oncology group study
    • 1:CAS:528:DC%2BC2cXhvVajtbo%3D
    • Fleming GF, Filiaci VL, Marzullo B, Zaino RJ, Davidson AS, Pearl M (2014) Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: a gynecologic oncology group study. Gynec Oncol 132:585-592
    • (2014) Gynec Oncol , vol.132 , pp. 585-592
    • Fleming, G.F.1    Filiaci, V.L.2    Marzullo, B.3    Zaino, R.J.4    Davidson, A.S.5    Pearl, M.6
  • 77
    • 37149010753 scopus 로고    scopus 로고
    • A phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer
    • Colombo N, McMeekin S, Schwartz P et al (2007) A phase II trial of the mTOR inhibitor AP23573 as a single agent in advanced endometrial cancer. J Clin Oncol 25:5516
    • (2007) J Clin Oncol , vol.25 , pp. 5516
    • Colombo, N.1    McMeekin, S.2    Schwartz, P.3
  • 78
    • 84913606847 scopus 로고    scopus 로고
    • Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer
    • 1:CAS:528:DC%2BC2cXhsVOhtrzN 25173583
    • Tsoref D, Welch S, Lau S, Biagi J, Tonkin K, Lee Ann Martin LA (2014) Phase II study of oral ridaforolimus in women with recurrent or metastatic endometrial cancer. Gynecol Oncol 135(2):184-189
    • (2014) Gynecol Oncol , vol.135 , Issue.2 , pp. 184-189
    • Tsoref, D.1    Welch, S.2    Lau, S.3    Biagi, J.4    Tonkin, K.5    Lee Ann Martin, L.A.6
  • 79
    • 77955770568 scopus 로고    scopus 로고
    • Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells
    • 1:CAS:528:DC%2BC3cXoslekt7k%3D 20135346
    • Zakikhani M, Blouin MJ, Piura E, Pollak MN (2010) Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Res Treat 123(1):271-279
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.1 , pp. 271-279
    • Zakikhani, M.1    Blouin, M.J.2    Piura, E.3    Pollak, M.N.4
  • 80
    • 84894041491 scopus 로고    scopus 로고
    • Metformin is associated with improved survival in endometrial cancer
    • 1:CAS:528:DC%2BC2cXivVOmtQ%3D%3D 24269517
    • Ko EM, Walter P, Jackson A, Clarkd L, Franasiak J et al (2014) Metformin is associated with improved survival in endometrial cancer. Gynecol Oncol 132:438-442
    • (2014) Gynecol Oncol , vol.132 , pp. 438-442
    • Ko, E.M.1    Walter, P.2    Jackson, A.3    Clarkd, L.4    Franasiak, J.5
  • 81
    • 84934450530 scopus 로고    scopus 로고
    • A phase II, single-arm study of RAD001 (Everolimus), Letrozole, and Metformin in patients with advanced or recurrent endometrial carcinoma
    • M.D. Anderson Cancer Center Bethesda (MD): National Library of Medicine (US) NLM identifier: NCT01797523
    • M.D. Anderson Cancer Center (2000) A phase II, single-arm study of RAD001 (Everolimus), Letrozole, and Metformin in patients with advanced or recurrent endometrial carcinoma. In: ClinicalTrials.gov [internet]. Bethesda (MD): National Library of Medicine (US). https://clinicaltrials.gov/ct2/show/study/NCT01797523 NLM identifier: NCT01797523
    • (2000) ClinicalTrials.gov [Internet]
  • 82
    • 84934450531 scopus 로고    scopus 로고
    • Paclitaxel and carboplatin with or without metformin hydrochloride in treating patients with stage III, IV, or Recurrent Endometrial Cancer
    • Gynecologic Oncology Group Bethesda (MD): National Library of Medicine (US) NLM identifier: NCT02065687
    • Gynecologic Oncology Group (2000) Paclitaxel and carboplatin with or without metformin hydrochloride in treating patients with stage III, IV, or Recurrent Endometrial Cancer. In: ClinicalTrials.gov [internet]. Bethesda (MD): National Library of Medicine (US). https://clinicaltrials.gov/ct2/show/study/NCT02065687 NLM identifier: NCT02065687
    • (2000) ClinicalTrials.gov [Internet]
  • 83
    • 84934450532 scopus 로고    scopus 로고
    • BKM120 as second-line therapy for advanced endometrial cancer
    • Novartis Pharmaceuticals Bethesda (MD): National Library of Medicine (US) NLM identifier: NCT 01289041
    • Novartis Pharmaceuticals (2000) BKM120 as second-line therapy for advanced endometrial cancer. In: ClinicalTrials.gov [internet]. Bethesda (MD): National Library of Medicine (US). http://clinicaltrials.gov/show/NCT01289041 NLM identifier: NCT 01289041
    • (2000) ClinicalTrials.gov [Internet]
  • 84
    • 84934450533 scopus 로고    scopus 로고
    • Study of XL147 (SAR245408) in Advanced or recurrent endometrial cancer
    • Sanofi Bethesda (MD): National Library of Medicine (US) NLM identifier: NCT 01013324
    • Sanofi (2000) Study of XL147 (SAR245408) in Advanced or recurrent endometrial cancer. In: ClinicalTrials.gov [internet]. Bethesda (MD): National Library of Medicine (US). http://clinicaltrials.gov/show/NCT01013324 NLM identifier: NCT 01013324
    • (2000) ClinicalTrials.gov [Internet]
  • 86
    • 84934450535 scopus 로고    scopus 로고
    • Akt Inhibitor MK2206 in treating patients with recurrent or advanced endometrial cancer
    • National Cancer Institute Bethesda (MD): National Library of Medicine (US) NLM identifier: NCT 01307631
    • National Cancer Institute (2000) Akt Inhibitor MK2206 in treating patients with recurrent or advanced endometrial cancer. In: ClinicalTrials.gov [internet]. Bethesda (MD): National Library of Medicine (US). http://clinicaltrials.gov/show/NCT01307631 NLM identifier: NCT 01307631
    • (2000) ClinicalTrials.gov [Internet]
  • 87
    • 84877679916 scopus 로고    scopus 로고
    • Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells
    • 1:CAS:528:DC%2BC3sXntlSis70%3D 23443805
    • Konecny GE, Kolarova T, O'Brien NA, Winterhoff B, Yang G et al (2013) Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther 12(5):632-642
    • (2013) Mol Cancer Ther , vol.12 , Issue.5 , pp. 632-642
    • Konecny, G.E.1    Kolarova, T.2    O'Brien, N.A.3    Winterhoff, B.4    Yang, G.5
  • 88
    • 84877928037 scopus 로고    scopus 로고
    • Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models
    • 1:CAS:528:DC%2BC3sXmvVemsLY%3D 23468082
    • Gozgit JM, Squillace RM, Wongchenko MJ, Miller D et al (2013) Combined targeting of FGFR2 and mTOR by ponatinib and ridaforolimus results in synergistic antitumor activity in FGFR2 mutant endometrial cancer models. Cancer Chemother Pharmacol 71:1315-1323
    • (2013) Cancer Chemother Pharmacol , vol.71 , pp. 1315-1323
    • Gozgit, J.M.1    Squillace, R.M.2    Wongchenko, M.J.3    Miller, D.4
  • 90
    • 84908030997 scopus 로고    scopus 로고
    • A phase II trial of brivanib in recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study
    • 1:CAS:528:DC%2BC2cXhtlSqs7fE 4278402 25019571
    • Powell MA, Sill MW, Goodfellow PJ, Benbrook DM, Lankes HA, Leslie KK et al (2014) A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study. Gynecol Oncol 135:38-43
    • (2014) Gynecol Oncol , vol.135 , pp. 38-43
    • Powell, M.A.1    Sill, M.W.2    Goodfellow, P.J.3    Benbrook, D.M.4    Lankes, H.A.5    Leslie, K.K.6
  • 91
    • 84920741562 scopus 로고    scopus 로고
    • A phase II evaluation of nintedanib (BIBF-1120) in the treatment of recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study
    • 1:CAS:528:DC%2BC2cXhslGrsL%2FN
    • Dizon DS, Michael Sill MW, Schilder JM, McGonigle KF, Rahman Z et al (2014) A phase II evaluation of nintedanib (BIBF-1120) in the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study. Gynec Oncol 135:441-445
    • (2014) Gynec Oncol , vol.135 , pp. 441-445
    • Dizon, D.S.1    Michael, S.M.2    Schilder, J.M.3    McGonigle, K.F.4    Rahman, Z.5
  • 92
    • 83355163329 scopus 로고    scopus 로고
    • GDC-0980 is a novel class i PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway
    • 1:CAS:528:DC%2BC3MXhsFylurfJ 21998291
    • Wallin JJ, Edgar KA, Guan J, Berry M, PriorWW Lee L et al (2011) GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther 10:2426-2436
    • (2011) Mol Cancer Ther , vol.10 , pp. 2426-2436
    • Wallin, J.J.1    Edgar, K.A.2    Guan, J.3    Berry, M.4    Priorww, L.L.5
  • 93
    • 51049109033 scopus 로고    scopus 로고
    • Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    • 1:CAS:528:DC%2BD1cXoslCgtb4%3D 18606717
    • Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C et al (2008) Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7:1851-1863
    • (2008) Mol Cancer Ther , vol.7 , pp. 1851-1863
    • Maira, S.M.1    Stauffer, F.2    Brueggen, J.3    Furet, P.4    Schnell, C.5    Fritsch, C.6
  • 94
    • 80054764153 scopus 로고    scopus 로고
    • Activity of dual PI3K/mTOR inhibitor, NVP-BEZ235, and mTOR inhibitor, RAD001 (everolimus), in endometrial cancer cell lines [abstract]
    • (supp abstr 5074)
    • Shoji K, Oda K, Nakagawa S, Ikeda Y, Kuramoto H, Nishida M et al (2010) Activity of dual PI3K/mTOR inhibitor, NVP-BEZ235, and mTOR inhibitor, RAD001 (everolimus), in endometrial cancer cell lines [abstract]. J Clin Oncol 28:15s (supp abstr 5074)
    • (2010) J Clin Oncol , vol.28 , pp. 15s
    • Shoji, K.1    Oda, K.2    Nakagawa, S.3    Ikeda, Y.4    Kuramoto, H.5    Nishida, M.6
  • 95
    • 84934450536 scopus 로고    scopus 로고
    • A study of GDC-0980 in the treatment of recurrent or persistent endometrial carcinoma
    • Genentech, Inc. Bethesda (MD): National Library of Medicine (US) NLM identifier: NCT01455493
    • Genentech, Inc. (2000) A study of GDC-0980 in the treatment of recurrent or persistent endometrial carcinoma. In: ClinicalTrials.gov [internet]. Bethesda (MD): National Library of Medicine (US). http://clinicaltrials.gov/show/NCT01455493 NLM identifier: NCT01455493
    • (2000) ClinicalTrials.gov [Internet]
  • 96
    • 0021281767 scopus 로고
    • Treatment of recurrent endometrial adenocarcinoma with a combination of doxorubicin and cisplatin
    • 1:STN:280:DyaL2c3ivVKnsg%3D%3D 6539567
    • Trope C, Johnsson JE, Simonsen E, Christiansen H, Cavallin-Stahl E, Horvath G (1984) Treatment of recurrent endometrial adenocarcinoma with a combination of doxorubicin and cisplatin. Am J Obstet Gynecol 149:379-381
    • (1984) Am J Obstet Gynecol , vol.149 , pp. 379-381
    • Trope, C.1    Johnsson, J.E.2    Simonsen, E.3    Christiansen, H.4    Cavallin-Stahl, E.5    Horvath, G.6
  • 97
    • 0037352608 scopus 로고    scopus 로고
    • Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: Definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group
    • 12598351
    • Van Wijk FH, Aapro MS, van Wijk FH, Bolis G et al (2003) Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group. Ann Oncol 14:441-448
    • (2003) Ann Oncol , vol.14 , pp. 441-448
    • Van Wijk, F.H.1    Aapro, M.S.2    Van Wijk, F.H.3    Bolis, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.