메뉴 건너뛰기




Volumn 132, Issue 3, 2014, Pages 585-592

Temsirolimus with or without megestrol acetate and tamoxifen for endometrial cancer: A gynecologic oncology group study

(15)  Fleming, Gini F a   Filiaci, Virginia L b   Marzullo, Brandon b   Zaino, Richard J c   Davidson, Susan A d   Pearl, Michael e   Makker, Vicky f   Burke II, James J g   Zweizig, Susan L h   Van Le, Linda i   Hanjani, Parviz j   Downey, Gordon k   Walker, Joan L l   Reyes, Henry D m   Leslie, Kimberly K m  


Author keywords

Endometrial cancer; Hormonal therapy; Megestrol acetate; Tamoxifen; Temsirolimus

Indexed keywords

MEGESTROL ACETATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TAMOXIFEN; TEMSIROLIMUS;

EID: 84896393304     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2014.01.015     Document Type: Article
Times cited : (100)

References (35)
  • 1
    • 0033003177 scopus 로고    scopus 로고
    • Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: A dose-response study by the Gynecologic Oncology Group
    • J.T. Thigpen, M.F. Brady, R.D. Alvarez, M.D. Adelson, H.D. Homesley, and A. Manetta et al. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group J Clin Oncol 17 1999 1736 1744
    • (1999) J Clin Oncol , vol.17 , pp. 1736-1744
    • Thigpen, J.T.1    Brady, M.F.2    Alvarez, R.D.3    Adelson, M.D.4    Homesley, H.D.5    Manetta, A.6
  • 2
    • 0742307280 scopus 로고    scopus 로고
    • Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: A Gynecologic Oncology Group study
    • J.V. Fiorica, V.L. Brunetto, P. Hanjani, S.S. Lentz, R. Mannel, and W. Andersen Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study Gynecol Oncol 92 2004 10 14
    • (2004) Gynecol Oncol , vol.92 , pp. 10-14
    • Fiorica, J.V.1    Brunetto, V.L.2    Hanjani, P.3    Lentz, S.S.4    Mannel, R.5    Andersen, W.6
  • 3
    • 34447643260 scopus 로고    scopus 로고
    • Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: A Gynecologic Oncology Group Study
    • M. Singh, R.J. Zaino, V.J. Filiaci, and K.K. Leslie Relationship of estrogen and progesterone receptors to clinical outcome in metastatic endometrial carcinoma: a Gynecologic Oncology Group Study Gynecol Oncol 106 2007 325 333
    • (2007) Gynecol Oncol , vol.106 , pp. 325-333
    • Singh, M.1    Zaino, R.J.2    Filiaci, V.J.3    Leslie, K.K.4
  • 4
    • 2942657617 scopus 로고    scopus 로고
    • Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: A Gynecologic Oncology Group Study
    • G.F. Fleming, V.L. Brunetto, D. Cella, K.Y. Look, G.C. Reid, and A.R. Munkarah et al. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study J Clin Oncol 22 2004 2159 2166
    • (2004) J Clin Oncol , vol.22 , pp. 2159-2166
    • Fleming, G.F.1    Brunetto, V.L.2    Cella, D.3    Look, K.Y.4    Reid, G.C.5    Munkarah, A.R.6
  • 5
    • 84865464494 scopus 로고    scopus 로고
    • Molecular targets and targeted therapeutics in endometrial cancer
    • B. Weigelt, and S. Banerjee Molecular targets and targeted therapeutics in endometrial cancer Curr Opin Oncol 24 2012 554
    • (2012) Curr Opin Oncol , vol.24 , pp. 554
    • Weigelt, B.1    Banerjee, S.2
  • 6
    • 84861690519 scopus 로고    scopus 로고
    • Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer
    • I. Diaz-Padilla, I. Duran, B.A. Clarke, and A.M. Oza Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer Cancer Treat Rev 38 2012 767 775
    • (2012) Cancer Treat Rev , vol.38 , pp. 767-775
    • Diaz-Padilla, I.1    Duran, I.2    Clarke, B.A.3    Oza, A.M.4
  • 7
    • 79951722712 scopus 로고    scopus 로고
    • Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer
    • C. Gu, Z. Zhang, Y. Yu, Liu, F. Zhao, and L. Yin et al. Inhibiting the PI3K/Akt pathway reversed progestin resistance in endometrial cancer Cancer Sci 102 2011 557 564
    • (2011) Cancer Sci , vol.102 , pp. 557-564
    • Gu, C.1    Zhang, Z.2    Yu, Y.3    Liu4    Zhao, F.5    Yin, L.6
  • 8
    • 84864265147 scopus 로고    scopus 로고
    • Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin
    • A. Pant, I.I. Lee, Z. Lu, B.R. Rueda, J. Schink, and J.J. Kim Inhibition of AKT with the orally active allosteric AKT inhibitor, MK-2206, sensitizes endometrial cancer cells to progestin PLoS One 7 2012 e41593
    • (2012) PLoS One , vol.7 , pp. 41593
    • Pant, A.1    Lee, I.I.2    Lu, Z.3    Rueda, B.R.4    Schink, J.5    Kim, J.J.6
  • 10
    • 24944591389 scopus 로고    scopus 로고
    • One- and two-stage designs for stratified phase II clinical trials
    • W.B. London, and M.N. Chang One- and two-stage designs for stratified phase II clinical trials Stat Med 24 2005 2597 2611
    • (2005) Stat Med , vol.24 , pp. 2597-2611
    • London, W.B.1    Chang, M.N.2
  • 11
    • 0022124023 scopus 로고
    • Confidence limits for probability of response in multistage phase II clinical trials
    • E.N. Atkinson, and B.W. Brown Confidence limits for probability of response in multistage phase II clinical trials Biometrics 41 1985 741 744
    • (1985) Biometrics , vol.41 , pp. 741-744
    • Atkinson, E.N.1    Brown, B.W.2
  • 13
    • 0003021979 scopus 로고
    • Jonckheere Tests for Ordered Alternatives
    • S. Kotz, N.L. Johnson, John Wiley & Sons New York
    • W. Pirie Jonckheere Tests for Ordered Alternatives S. Kotz, N.L. Johnson, Encyclopedia of Statistical Sciences vol. 4 1983 John Wiley & Sons New York 315 318
    • (1983) Encyclopedia of Statistical Sciences , vol.4 , pp. 315-318
    • Pirie, W.1
  • 14
    • 84972545970 scopus 로고
    • A survey of exact inference for contingency tables
    • A. Agresti A survey of exact inference for contingency tables Stat Sci 7 1992 131 153
    • (1992) Stat Sci , vol.7 , pp. 131-153
    • Agresti, A.1
  • 15
    • 0000336139 scopus 로고
    • Regression Models and Life Tables
    • [187-20]
    • D.R. Cox Regression Models and Life Tables J R Stat Soc Ser B 20 1972 [187-20]
    • (1972) J R Stat Soc ser B , vol.20
    • Cox, D.R.1
  • 16
    • 33845382806 scopus 로고
    • Nonparametric estimation from incomplete observations
    • E.L. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
    • (1958) J Am Stat Assoc , vol.53 , pp. 457-481
    • Kaplan, E.L.1    Meier, P.2
  • 17
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • A.M. Oza, L. Elit, M.S. Tsao, S. Kamel-Reid, J. Biagi, and D.M. Provencher et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group J Clin Oncol 29 2011 3278 3285
    • (2011) J Clin Oncol , vol.29 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3    Kamel-Reid, S.4    Biagi, J.5    Provencher, D.M.6
  • 18
    • 84888285940 scopus 로고    scopus 로고
    • Applicability of the concept of "platinum sensitivity" to recurrent endometrial cancer: The SGSG-012/GOTIC-004/Intergroup study
    • S. Nagao, S. Nishio, H. Michimae, H. Tanabe, S. Okada, and T. Otsuki et al. Applicability of the concept of "platinum sensitivity" to recurrent endometrial cancer: The SGSG-012/GOTIC-004/Intergroup study Gynecol Oncol 131 2013 567 573
    • (2013) Gynecol Oncol , vol.131 , pp. 567-573
    • Nagao, S.1    Nishio, S.2    Michimae, H.3    Tanabe, H.4    Okada, S.5    Otsuki, T.6
  • 19
    • 78649592049 scopus 로고    scopus 로고
    • A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
    • B.M. Slomovitz, K.H. Lu, T. Johnston, R.L. Coleman, M. Munsell, and R.R. Broaddus et al. A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma Cancer 116 2010 5415 5419
    • (2010) Cancer , vol.116 , pp. 5415-5419
    • Slomovitz, B.M.1    Lu, K.H.2    Johnston, T.3    Coleman, R.L.4    Munsell, M.5    Broaddus, R.R.6
  • 21
    • 20844434805 scopus 로고    scopus 로고
    • The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers-a study of the National Cancer Institute of Canada Clinical Trials Group
    • B.B. Ma, A. Oza, E. Eisenhauer, G. Stanimir, M. Carey, and W. Chapman et al. The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers-a study of the National Cancer Institute of Canada Clinical Trials Group Int J Gynecol Cancer 14 2004 650 658
    • (2004) Int J Gynecol Cancer , vol.14 , pp. 650-658
    • Ma, B.B.1    Oza, A.2    Eisenhauer, E.3    Stanimir, G.4    Carey, M.5    Chapman, W.6
  • 22
    • 84864558874 scopus 로고    scopus 로고
    • Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: A GINECO study
    • T. Bachelot, C. Bourgier, C. Cropet, I. Ray-Coquard, J.M. Ferrero, and G. Freyer et al. Randomized phase II trial of everolimus in combination with tamoxifen in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer with prior exposure to aromatase inhibitors: a GINECO study J Clin Oncol 30 2012 2718 2724
    • (2012) J Clin Oncol , vol.30 , pp. 2718-2724
    • Bachelot, T.1    Bourgier, C.2    Cropet, C.3    Ray-Coquard, I.4    Ferrero, J.M.5    Freyer, G.6
  • 23
    • 84862573175 scopus 로고    scopus 로고
    • Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mTOR inhibitor) in metastatic breast cancer
    • G.S. Bhattacharyya, J. Biswas, J.K. Singh, M. Singh, K. Govindbabu, and A.A. Ranade et al. Reversal of tamoxifen resistance (hormone resistance) by addition of sirolimus (mTOR inhibitor) in metastatic breast cancer Eur J Cancer 47 2011 9
    • (2011) Eur J Cancer , vol.47 , pp. 9
    • Bhattacharyya, G.S.1    Biswas, J.2    Singh, J.K.3    Singh, M.4    Govindbabu, K.5    Ranade, A.A.6
  • 24
    • 0032887010 scopus 로고    scopus 로고
    • Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia
    • C.L. Loprinzi, J.W. Kugler, J.A. Sloan, J.A. Mailliard, J.E. Krook, and M.B. Wilwerding et al. Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia J Clin Oncol 17 1999 3299 3306
    • (1999) J Clin Oncol , vol.17 , pp. 3299-3306
    • Loprinzi, C.L.1    Kugler, J.W.2    Sloan, J.A.3    Mailliard, J.A.4    Krook, J.E.5    Wilwerding, M.B.6
  • 25
    • 34247279338 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis
    • S. Huber, C.J. Bruns, G. Schmid, P.C. Hermann, C. Conrad, and H. Niess et al. Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis Kidney Int 71 2007 771 777
    • (2007) Kidney Int , vol.71 , pp. 771-777
    • Huber, S.1    Bruns, C.J.2    Schmid, G.3    Hermann, P.C.4    Conrad, C.5    Niess, H.6
  • 27
    • 84865699554 scopus 로고    scopus 로고
    • Decreased risk of radiation pneumonitis with incidental concurrent use of angiotensin-converting enzyme inhibitors and thoracic radiation therapy
    • J. Kharofa, E.P. Cohen, R. Tomic, Q. Xiang, and E. Gore Decreased risk of radiation pneumonitis with incidental concurrent use of angiotensin-converting enzyme inhibitors and thoracic radiation therapy Int J Radiat Oncol Biol Phys 84 2012 238 243
    • (2012) Int J Radiat Oncol Biol Phys , vol.84 , pp. 238-243
    • Kharofa, J.1    Cohen, E.P.2    Tomic, R.3    Xiang, Q.4    Gore, E.5
  • 28
    • 84862777505 scopus 로고    scopus 로고
    • Clinical assessment of PTEN loss in endometrial carcinoma: Immunohistochemistry outperforms gene sequencing
    • B. Djordjevic, B.T. Hennessy, J. Li, B.A. Barkoh, R. Luthra, and G.B. Mills et al. Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing Mod Pathol 25 2012 699 708
    • (2012) Mod Pathol , vol.25 , pp. 699-708
    • Djordjevic, B.1    Hennessy, B.T.2    Li, J.3    Barkoh, B.A.4    Luthra, R.5    Mills, G.B.6
  • 29
    • 80054762839 scopus 로고    scopus 로고
    • A randomized phase II (RP2) trial of ridaforolimus (R) compared with progestin (P) or chemotherapy (C) in female adult patients with advanced endometrial carcinoma
    • [ASCO 5009 (abstr)]
    • A.M. Oza, A. Poveda, A.R. Clamp, S. Pignata, G. Scambia, and J.M. Del Campo et al. A randomized phase II (RP2) trial of ridaforolimus (R) compared with progestin (P) or chemotherapy (C) in female adult patients with advanced endometrial carcinoma J Clin Oncol 29 2011 [ASCO 5009 (abstr)]
    • (2011) J Clin Oncol , vol.29
    • Oza, A.M.1    Poveda, A.2    Clamp, A.R.3    Pignata, S.4    Scambia, G.5    Del Campo, J.M.6
  • 30
    • 84890554032 scopus 로고    scopus 로고
    • Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: A GINECO group study
    • O. Tredan, I. Treilleux, Q. Wang, N. Gane, D. Pissaloux, and N. Bonnin et al. Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study Target Oncol 8 2013 243 251
    • (2013) Target Oncol , vol.8 , pp. 243-251
    • Tredan, O.1    Treilleux, I.2    Wang, Q.3    Gane, N.4    Pissaloux, D.5    Bonnin, N.6
  • 31
    • 80054785459 scopus 로고    scopus 로고
    • A mechanism for synergy with combined mTOR and PI3 kinase inhibitors
    • S. Yang, X. Xiao, X. Meng, and K.K. Leslie A mechanism for synergy with combined mTOR and PI3 kinase inhibitors PLoS One 6 2011 e26343
    • (2011) PLoS One , vol.6 , pp. 26343
    • Yang, S.1    Xiao, X.2    Meng, X.3    Leslie, K.K.4
  • 32
    • 84886394046 scopus 로고    scopus 로고
    • New strategies in endometrial cancer: Targeting the PI3K/mTOR pathway - - the devil is in the details
    • A.P. Myers New strategies in endometrial cancer: Targeting the PI3K/mTOR pathway - - The devil is in the details Clin Cancer Res 19 2013 5264 5274
    • (2013) Clin Cancer Res , vol.19 , pp. 5264-5274
    • Myers, A.P.1
  • 33
    • 84878621819 scopus 로고    scopus 로고
    • Everolimus as second-or third line treatment of advanced endometrial cancer: ENDORAD, a phase II trial of GINECO
    • I. Ray-Coquard, L. Favier, and B. Weber et al. Everolimus as second-or third line treatment of advanced endometrial cancer: ENDORAD, a phase II trial of GINECO Br J Cancer 108 2013 1771 1777
    • (2013) Br J Cancer , vol.108 , pp. 1771-1777
    • Ray-Coquard, I.1    Favier, L.2    Weber, B.3
  • 34
    • 84875435116 scopus 로고    scopus 로고
    • Ridaforolimus as a single agent in advanced endometrial cancer: Results of a single-arm phase 2 trial
    • N. Colombo, D.S. McMeekin, P.E. Schwartz, C. Sessa, P.A. Gehrig, and R. Holloway et al. Ridaforolimus as a single agent in advanced endometrial cancer: Results of a single-arm phase 2 trial Br J Cancer 108 2013 1021 1026
    • (2013) Br J Cancer , vol.108 , pp. 1021-1026
    • Colombo, N.1    McMeekin, D.S.2    Schwartz, P.E.3    Sessa, C.4    Gehrig, P.A.5    Holloway, R.6
  • 35
    • 80053614492 scopus 로고    scopus 로고
    • A phase II study of oral ridaforolimus in patients with metastatic and/or locally advanced recurrent endometrial cancer: NCIC CTG IND 192
    • [ASCO 5013 (abstr)]
    • H. Mackay, S. Welch, M.S. Tsao, J.J. Biagi, L. Elit, and P. Ghatage et al. A phase II study of oral ridaforolimus in patients with metastatic and/or locally advanced recurrent endometrial cancer: NCIC CTG IND 192 J Clin Oncol 29 2011 [ASCO 5013 (abstr)]
    • (2011) J Clin Oncol , vol.29
    • Mackay, H.1    Welch, S.2    Tsao, M.S.3    Biagi, J.J.4    Elit, L.5    Ghatage, P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.